Smart dry powder inhalers and intelligent adherence management

Häußermann, S.; Arendsen, Laura J.; Pritchard, J.N.

doi:10.1016/j.addr.2022.114580

Cited by 9 publications

(6 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other devices, such as the INhaler Compliance Assessment eModule, are added to an inhaler and analyze sound recordings of inhaler use to detect an incorrect inhaling technique or estimate PIF [102][103][104]. Many other smart inhalers are being developed [100,105]. Some will only help to ensure and reinforce treatment adherence, whereas others will identify inhaler misuse and correct it prematurely, e.g., through a smartphone application that gives instant feedback [99].…”

Section: Discussionmentioning

confidence: 99%

“…Although not yet widely used in clinical practice, all these smart inhalers could be very useful in the future to help select a suitable inhaler and ensure its correct use [105,107,108].…”

Section: Discussionmentioning

confidence: 99%

“…However, due to the small study populations, the clinical effect of such tools cannot yet be conclusively determined [106]. Although not yet widely used in clinical practice, all these smart inhalers could be very useful in the future to help select a suitable inhaler and ensure its correct use [105, 107, 108].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Patient Characteristics to Consider When Selecting an Inhaler for the Treatment of Chronic Obstructive Pulmonary Disease and Available Assessment Methods: A Narrative Review

Renaud,

Suter,

Grandmaison

2023

Respiration

View full text Add to dashboard Cite

Inhaler misuse is common among patients with chronic obstructive pulmonary disease and associated with poor disease control. Many patient characteristics are reported to impact inhaler use, but there are no studies in the literature on the best way to evaluate them. This narrative review aims to identify patient characteristics that influence the correct use of an inhaler and describe the tools available for their assessment. First, we searched four different databases to identify reviews describing patient characteristics reported to impact inhaler use. In a second step, ways to characterize these aspects were searched using the same databases. Fifteen patient characteristics impacting on the use of inhalers were identified. Peak inspiratory flow, dexterity, and cognitive impairment were the most studied characteristics and appeared to have the highest impact on the correct use of inhalers. Notably, peak inspiratory flow can be reliably assessed in clinical practice using the In-Check Dial<sup>®</sup>. Triggering coordination, breath retention, collaboration/consciousness, and muscle strength in the fingers were important characteristics, but insufficient data exist to recommend the use of a specific tool for their assessment in daily practice. Other identified characteristics have a more uncertain impact. A demonstration of inhalation technique by the patient, combined with the measurement of peak inspiratory flow using the In-Check Dial<sup>®</sup>, appears to be an effective strategy to assess the characteristics with the highest impact on the correct use of an inhaler. In the future, “smart” inhalers could also play a decisive role in this area.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Although not yet widely used in clinical practice, all these smart inhalers could be very useful in the future to help select a suitable inhaler and ensure its correct use [105,107,108].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Patient Characteristics to Consider When Selecting an Inhaler for the Treatment of Chronic Obstructive Pulmonary Disease and Available Assessment Methods: A Narrative Review

Renaud,

Suter,

Grandmaison

2023

Respiration

View full text Add to dashboard Cite

show abstract

“…Analogous sensor systems along with software were developed for DPI inhalers [ 135 ], where inhalation dynamics are known to be crucial for generating an aerosol dose with the desired PSD [ 106 ]. The number of smart devices and sensors currently available on the market is substantial (refer, e.g., to [ 136 , 137 ] for more comprehensive data), so only a few of the most popular systems are listed in Table 2 . Most of them have a module enabling wireless communication with mobile phone applications, which makes them even more convenient for use by patients.…”

Section: Selected Concepts and Methods Of Improvement Of Targeted Aer...mentioning

confidence: 99%

Towards More Precise Targeting of Inhaled Aerosols to Different Areas of the Respiratory System

Sosnowski

2024

Pharmaceutics

View full text Add to dashboard Cite

Pharmaceutical aerosols play a key role in the treatment of lung disorders, but also systemic diseases, due to their ability to target specific areas of the respiratory system (RS). This article focuses on identifying and clarifying the influence of various factors involved in the generation of aerosol micro- and nanoparticles on their regional distribution and deposition in the RS. Attention is given to the importance of process parameters during the aerosolization of liquids or powders and the role of aerosol flow dynamics in the RS. The interaction of deposited particles with the fluid environment of the lung is also pointed out as an important step in the mass transfer of the drug to the RS surface. The analysis presented highlights the technical aspects of preparing the precursors to ensure that the properties of the aerosol are suitable for a given therapeutic target. Through an analysis of existing technical limitations, selected strategies aimed at enhancing the effectiveness of targeted aerosol delivery to the RS have been identified and presented. These strategies also include the use of smart inhaling devices and systems with built-in AI algorithms.

show abstract

“…Developing personalized biological therapies and improving drug delivery methods will undoubtedly be the main trends in the future. For example, studies have explored the use of biomarkers to identify patients who may benefit from specific biologicals and the development of smart inhalers that can monitor adherence and provide feedback to patients [ 109 ]. Additionally, research is ongoing to develop new biologicals that target novel pathways and cells involved in respiratory diseases [ 110 ].…”

Section: Novel Biologicalsmentioning

confidence: 99%

Advancing Treatment Strategies: A Comprehensive Review of Drug Delivery Innovations for Chronic Inflammatory Respiratory Diseases

Wang,

Shao

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Chronic inflammatory respiratory diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis, present ongoing challenges in terms of effective treatment and management. These diseases are characterized by persistent inflammation in the airways, leading to structural changes and compromised lung function. There are several treatments available for them, such as bronchodilators, immunomodulators, and oxygen therapy. However, there are still some shortcomings in the effectiveness and side effects of drugs. To achieve optimal therapeutic outcomes while minimizing systemic side effects, targeted therapies and precise drug delivery systems are crucial to the management of these diseases. This comprehensive review focuses on the role of drug delivery systems in chronic inflammatory respiratory diseases, particularly nanoparticle-based drug delivery systems, inhaled corticosteroids (ICSs), novel biologicals, gene therapy, and personalized medicine. By examining the latest advancements and strategies in these areas, we aim to provide a thorough understanding of the current landscape and future prospects for improving treatment outcomes in these challenging conditions.

show abstract

Smart dry powder inhalers and intelligent adherence management

Cited by 9 publications

References 47 publications

Patient Characteristics to Consider When Selecting an Inhaler for the Treatment of Chronic Obstructive Pulmonary Disease and Available Assessment Methods: A Narrative Review

Patient Characteristics to Consider When Selecting an Inhaler for the Treatment of Chronic Obstructive Pulmonary Disease and Available Assessment Methods: A Narrative Review

Towards More Precise Targeting of Inhaled Aerosols to Different Areas of the Respiratory System

Advancing Treatment Strategies: A Comprehensive Review of Drug Delivery Innovations for Chronic Inflammatory Respiratory Diseases

Contact Info

Product

Resources

About