Smart Injectable Hydrogels for Cancer Immunotherapy

Chao, Yu; Chen, Qian; Liu, Zhuang

doi:10.1002/adfm.201902785

Cited by 208 publications

(151 citation statements)

References 97 publications

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“…Thus, compared to ordinary hydrogels, injectable hydrogels have recently drawn significant attention as drug delivery system (Figure 1). [11][12][13][14][15][16][17][18][19] Injectable hydrogels can be implanted through a minimally invasive procedure that can significantly reduce patients' discomfort and pain while decreasing healing time, be achieved at low cost, and be applied into hard-to-reach tissue sites. Thus, their clinical application is widespread.…”

Section: Injectable Hydrogelsmentioning

confidence: 99%

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

222

152

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Injectable hydrogels have received considerable interest in the biomedical field due to their potential applications in minimally invasive local drug delivery, more precise implantation, and site‐specific drug delivery into poorly reachable tissue sites and into interface tissues, where wound healing takes a long time. Injectable hydrogels, such as in situ forming and/or shear‐thinning hydrogels, can be generated using chemically and/or physically crosslinked hydrogels. Yet, for controlled and local drug delivery applications, the ideal injectable hydrogel should be able to provide controlled and sustained release of drug molecules to the target site when needed and should limit nonspecific drug molecule distribution in healthy tissues. Thus, such hydrogels should sense the environmental changes that arise in disease states and be able to release the optimal amount of drug over the necessary time period to the target region. To address this, researchers have designed stimuli‐responsive injectable hydrogels. Stimuli‐responsive hydrogels change their shape or volume when they sense environmental stimuli, e.g., pH, temperature, light, electrical signals, or enzymatic changes, and deliver an optimal concentration of drugs to the target site without affecting healthy tissues.

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Section: Injectable Hydrogelsmentioning

confidence: 99%

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

222

152

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“…[ 1,2 ] In addition, a significant deformation in shape can be accomplished through sol–gel transition and swelling–shrinking volume phase transition; this is achieved by employing the stimuli‐sensitive polymers as a backbone structure in elastic 3D networks, [ 3–6 ] which leads to the formation of smart sensors, actuators, and artificial muscles. Recent remarkable advances in this research field have enabled the construction of a wide variety of hydrogels with unique properties, such as stimuli responsiveness, [ 6–10 ] injectability, [ 11,12 ] self‐healing ability, [ 13–16 ] and mechanical toughness. [ 17–19 ]…”

Section: Figurementioning

confidence: 99%

Transparent, High‐Strength, and Shape Memory Hydrogels from Thermo‐Responsive Amino Acid–Derived Vinyl Polymer Networks

Koga

Tomimori

Higashi

2020

Macromol. Rapid Commun.

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Herein, the formation of unique shape‐memory hydrogels that are composed of thermo‐responsive amino‐acid‐derived vinyl polymer networks is reported; these are readily prepared by radical copolymerization of N‐acryloyl glycinamide with commercially available cross‐linkers, namely, methylenebis(acrylamide) and poly(ethylene glycol) diacrylate. These hydrogels are transparent (>90% transmittance at 600 nm) and are comprised of 97–70 wt% water. Furthermore, these contain both chemical and physical cross‐linkages that are based on the multiple hydrogen bonds attained via amino acid units; this composition is aimed at generating opposing stimuli‐responsive characters, namely, chemically stable and thermo‐sensitive properties. A cooperative interplay of these two networks enables the hydrogels to exhibit a decent mechanical toughness (breaking strength ≈0.3 MPa and breaking elongation >600%) and a shape fix/memory capability. The temporary shape is easily fixed by cooling at 4 °C after deformation at high temperature, and it instantly recovers its original shape through reheating. Furthermore, a multi‐shape memory effect is achieved by incorporating the pH‐responsive N‐acryloyl alanine unit into the hydrogel system as a comonomer; in this system, three distinct shapes can be fixed through temperature and pH manipulations. This facilely attainable shape memory hydrogel has significant potential in various fields, such as soft actuators, sensors, and biomedical materials.

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“…The design of a bio-conjugated hydrogel scaffold depends on the specific application and also it has to be tailored to interact with the biomolecules incorporated within its structure. The entrapment and tethering of biomolecules for their subsequent release (or the release of their associated products) has brought a lot of interest in various biomedical research areas [ 166 , 167 , 168 , 169 ]. The incorporation of various biomolecules ( Table 2 ) into the hydrogel matrix without affecting their conformation and activity is still challenging.…”

Section: Introduction Of Biomolecules Within the Hydrogel Networkmentioning

confidence: 99%

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

et al. 2020

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Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompatibility, responsivity and displaying tunable chemical and mechanical properties. A complex scenario of molecular factors and conditions have to be taken into account to ensure the correct functionality of the bio-hydrogel as a scaffold or a delivery system, including the polymer backbone and biomolecule choice, polymerization conditions, architecture and biocompatibility. In this review, we present these key factors and conditions that have to match together to ensure the correct functionality of the bio-conjugated hydrogel. We then present recent examples of bio-conjugated hydrogel systems paving the way for regenerative medicine applications.

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Smart Injectable Hydrogels for Cancer Immunotherapy

Cited by 208 publications

References 97 publications

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Transparent, High‐Strength, and Shape Memory Hydrogels from Thermo‐Responsive Amino Acid–Derived Vinyl Polymer Networks

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

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