Smart Instructive Polymer Substrates for Tissue Engineering

Custódio, Catarina A.; Campo, Aránzazu del; Reis, Rui L.; Mano, J. F.

doi:10.1016/b978-0-08-102416-4.00012-0

Cited by 9 publications

(5 citation statements)

References 183 publications

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“…These dendrimers induced coacervation (liquid-liquid phase separation) during temperature changes. Tissue engineering, drug delivery, or diagnosis applications from thermoresponsive nanomaterials were achieved from different hydrogels with various nanostructures and behaviors [27,28,[52][53][54] or smart polymer substrates [55]. However, for the as-mentioned biomedical applications, responsive behavior must be offset with biocompatibility and degradation kinetics [53].…”

Section: Physical Stimuli Nanomaterialsmentioning

confidence: 99%

Smart Nanomaterials for Biomedical Applications—A Review

Aflori¹

2021

Nanomaterials

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Recent advances in nanotechnology have forced the obtaining of new materials with multiple functionalities. Due to their reduced dimensions, nanomaterials exhibit outstanding physio-chemical functionalities: increased absorption and reactivity, higher surface area, molar extinction coefficients, tunable plasmonic properties, quantum effects, and magnetic and photo properties. However, in the biomedical field, it is still difficult to use tools made of nanomaterials for better therapeutics due to their limitations (including non-biocompatible, poor photostabilities, low targeting capacity, rapid renal clearance, side effects on other organs, insufficient cellular uptake, and small blood retention), so other types with controlled abilities must be developed, called “smart” nanomaterials. In this context, the modern scientific community developed a kind of nanomaterial which undergoes large reversible changes in its physical, chemical, or biological properties as a consequence of small environmental variations. This systematic mini-review is intended to provide an overview of the newest research on nanosized materials responding to various stimuli, including their up-to-date application in the biomedical field.

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Section: Physical Stimuli Nanomaterialsmentioning

confidence: 99%

Smart Nanomaterials for Biomedical Applications—A Review

Aflori¹

2021

Nanomaterials

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“…Smart scaffolds are able to modulate their properties, in a controlled manner, in response to external stimuli [32] such as temperature, pH, electric or magnetic field [33] to actively enhance regeneration by mimicking the dynamic nature of the extracellular environment. The influence of electrical stimulation (ES) on cell response has been well documented in the literature through the activation of bioelectrical cues, which act as instructive signals that mediate changes in the proliferation, differentiation and migration of cells [34][35][36].…”

Section: Smart Scaffoldsmentioning

confidence: 99%

Piezoelectric materials and systems for tissue engineering and implantable energy harvesting devices for biomedical applications

Jarkov

Allan

Bowen

et al. 2021

International Materials Reviews

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Recently, the development of smart materials and the study of their properties has provided an innovative approach to the field of tissue engineering. Piezoelectrics, which are able to generate electric charge in response to mechanical stress or strain have been utilised in the stimulation of electrophysiologically responsive cells , including those found in bone, muscle, and the central and peripheral nervous systems. This area of study has experienced tremendous growth in the past decade in terms of both the array of piezoelectric materials and analytical methods by which they are evaluated in relation to specific tissue types. This review provides a critical and comprehensive overview of the most recent advances in this emerging field. Furthermore, it will extend the scope to examine the most recent developments in piezoelectric biomedical devices that extract energy from physiological processes to either power biomedical implants or act as biomedical sensors .

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“…As part of an interdisciplinary worldwide effort to enhance the impact of photoresponsive polymer materials, our group has an interest in combining the top-down fabrication technique of photopatterning with the bottom-up deposition approach of layer-by-layer self-assembly. As presented throughout this article, photodegradable LbL films present a toolbox for controlling matter and interfaces on the micro- and nanoscale, offering potential in, for example, innovative tissue engineering platforms capable of controllable cellular adhesion, migration, and differentiation. − …”

Section: Photoresponsive Lbl Filmsmentioning

confidence: 99%

Combining Top-Down and Bottom-Up with Photodegradable Layer-by-Layer Films

Feeney

Thomas

2019

Langmuir

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Layer-by-layer (LbL) self-assembly of polymer coatings is a bottom-up fabrication technique with broad applicability across a wide range of materials and applications that require control over interfacial properties. While most LbL coatings are chemically uniform in directions both tangent and perpendicular to their substrate, control over the properties of surface coatings as a function of space can enhance their function. To contribute to this rapidly advancing field, our group has focused on the top-down spatiotemporal control possible with photochemically reactive LbL coatings, harnessed through charge-shifting polyelectrolytes enabled by photocleavable ester pendants. The photolysis of the photocleavable esters degrades LbL films containing these polyelectrolytes. The chemical structures of the photocleavable groups dictate the wavelengths responsible for disrupting these coatings, ranging from ultraviolet to near-infrared in our work. In addition, spatially segregating reactive groups into “compartments” within LbL films has enabled us to fabricate reactive free-standing polymer films and multiheight photopatterned coatings. Overall, by combining bottom-up and top-down approaches, photoreactive LbL films enable precise control over the interfacial properties of polymer and composite coatings.

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Smart Instructive Polymer Substrates for Tissue Engineering

Cited by 9 publications

References 183 publications

Smart Nanomaterials for Biomedical Applications—A Review

Smart Nanomaterials for Biomedical Applications—A Review

Piezoelectric materials and systems for tissue engineering and implantable energy harvesting devices for biomedical applications

Combining Top-Down and Bottom-Up with Photodegradable Layer-by-Layer Films

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