Smart Magnetically Engineering Colloids and Biothin Films for Diagnostics Applications

Ahsan, Adeel; Aziz, Arslan; Arshad, Muhammad; Ali, Omair; Nauman, Mushaid; Ahmad, Naveed; Elaı̈ssari, Abdelhamid

doi:10.1166/jcsb.2013.1031

Cited by 20 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Complying with this notion, practice of nanotechnology in medicine has shown exciting prospect for development of novel targeted delivery system. 52–56 MNPs possess distinct advantage for its use as a platform for theranostic nanomedicine for CNS diseases because it could simultaneously be used as carrier for speedy and targeted drug delivery (mediated by external non-invasive magnetic force) and MRI contrast agent (due to inherent superparamagnetism). In our studies, as a first step towards specific drug targeting to prevent the neuropathogenesis associated with recreational drugs, we have developed for the first time a MNPs based nanoformulation, which shows that CTOP (a µ opioid receptor blocker : anti-opioid agent) can be immobilized on MNPs.…”

Section: Resultsmentioning

confidence: 99%

Therapeutical Neurotargeting via Magnetic Nanocarrier: Implications to Opiate-Induced Neuropathogenesis and NeuroAIDS

Sagar¹,

Pilakka-Kanthikeel²,

Atluri³

et al. 2015

j biomed nanotechnol

View full text Add to dashboard Cite

Magnetite (Fe3O4) is the most commonly and extensively explored magnetic nanoparticles (MNPs) for drug-targeting and imaging in the field of biomedicine. Nevertheless, its potential application as safe and effective drug-carrier for CNS (Central Nervous System) anomalies is very limited. Previous studies have shown an entangled epidemic of opioid use and HIV infection and increased neuropathogenesis. Opiate such as morphine, heroine, etc. are used frequently as recreational drugs. Existing treatments to alleviate the action of opioid are less effective at CNS level due to impermeability of therapeutic molecules across brain barriers. Thus, development of an advanced nanomedicine based approach may pave the way for better treatment strategies. We herein report magnetic nanoformulation of a highly selective and potent morphine antagonist, CTOP (D-Pen-Cys-Tyr-DTrp-Orn-Thr-Pen-Thr-NH2), which is impenetrable to the brain. MNPs, synthesized in size range from 25 to 40 nm, were characterized by Transmission electron microscopy and assembly of MNPs-CTOP nanoformulations were confirmed by FTIR spectroscopy and fluorescent detection. Flow-cytometry analysis showed that biological efficacy of this nanoformulation in prevention of morphine induced apoptosis in peripheral blood mononuclear cells remains equivalent to that of free CTOP. Similarly, confocal microscopy reveals comparable efficacy of free and MNPs bound CTOP in protecting modulation of neuronal dendrite and spine morphology during morphine exposure and morphine-treated HIV infection. Further, typical transmigration assay showed increased translocation of MNPs across in vitro blood-brain barrier upon exposure of external magnetic force where barrier integrity remains unaltered. Thus, the developed nanoformulation could be effective in targeting brain by application of external magnetic force to treat morphine addiction in HIV patients.

show abstract

Section: Resultsmentioning

confidence: 99%

Therapeutical Neurotargeting via Magnetic Nanocarrier: Implications to Opiate-Induced Neuropathogenesis and NeuroAIDS

Sagar¹,

Pilakka-Kanthikeel²,

Atluri³

et al. 2015

j biomed nanotechnol

View full text Add to dashboard Cite

show abstract

“…Thin films of nickel ferrites and chitosan were fabricated by the LBL technique and investigated for their ability to generate an intensity difference using blood as a test liquid; however, T1 and T2 images were not explored in detail [12]. Using the same manual fabrication protocol, thin films were designed, fabricated, and characterized but the magnetic behavior of the films was not tested [13].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Colloidal Particles in Combinatorial Thin-Film Gradients for Magnetic Resonance Imaging and Hyperthermia

Khizar

Ahmad

Saleem³

et al. 2020

Advances in Polymer Technology

Self Cite

View full text Add to dashboard Cite

A stable oil-in-water (O/W) magnetic emulsion was prepared by the emulsification of organic ferrofluid in an aqueous media, and its theranostic applications were investigated. The synthesis and characterization of the organic ferrofluid were carried out comprising of superparamagnetic maghemite nanoparticles with oleic acid coating stabilized in octane. Both exhibit spherical morphology with a mean size of 6 nm and 200 nm, respectively, as determined by TEM. Thermogravimetric analysis was carried out to determine the chemical composition of the emulsion. The research work described here is novel and elaborates the fabrication of thin-film gradients with 5, 10, 15, and 20 bilayers by layer-by-layer technique using polydimethyl diallyl ammonium chloride (PDAC) and prepared magnetic colloidal particles. The thin-film gradients were characterized for their roughness, morphology, and wettability. The developed gradient films and colloids were explored in magnetic resonance imaging (MRI) and hyperthermia. T1- and T2-weighted images and their corresponding signal intensities were obtained at 1.5 T. A decreasing trend in signal intensities with an increase in nanoparticle concentration in colloids and along the gradient was observed in T2-weighted images. The hyperthermia capability was also evaluated by measuring temperature rise and calculating specific absorption rates (SAR). The SAR of the colloids at 259 kHz, 327 kHz, and 518 kHz were found to be 156 W/g, 255 W/g, and 336 W/g, respectively. The developed magnetic combinatorial thin-film gradients present a significant potential for the future efficient simultaneous diagnostic and therapeutic bioapplications.

show abstract

“…Colloidal particles are used as solid support in biomedical field, which include immunoassay, cell sorting, and nucleic acid capturing and detection . However, such applications require different tedious and time consuming separation processes, mainly when two kinds of separation processes are used, i.e.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of submicron hybrid magnetic latex particles

Jamshaid

Tenório‐Neto

Eissa

et al. 2015

Polymers for Advanced Techs

Self Cite

View full text Add to dashboard Cite

International audienceMicrometer magnetic hybrid particles are of great interest in biomedical field, and various morphologies have been prepared via encapsulation processes. Regarding submicron, only few processes have been investigated and the most recent one leading to highly magnetic submicron magnetic hybrid particles is based on oil in water magnetic emulsion (MES) transformation. The encapsulation of magnetic iron oxide nanoparticles forming oil in water MES was investigated using different styrene/cross-linker divinylbenzene volume ratio in the presence of potassium persulfate initiator. The encapsulation performed in this work is basically conducted by using well-defined oil in water MES as a seed in radical emulsion polymerization. The chemical composition, morphology, iron oxide content, magnetic properties, electrokinetic properties, particle size, and size distribution of the prepared magnetic hybrid particles were examined using various techniques. The desired perfect magnetic core and polymer shell morphology were successfully obtained, and the final magnetic hybrid particles are superparamagnetic in nature and exhibit high iron oxide content (64 wt %)

show abstract

Smart Magnetically Engineering Colloids and Biothin Films for Diagnostics Applications

Cited by 20 publications

References 0 publications

Therapeutical Neurotargeting via Magnetic Nanocarrier: Implications to Opiate-Induced Neuropathogenesis and NeuroAIDS

Therapeutical Neurotargeting via Magnetic Nanocarrier: Implications to Opiate-Induced Neuropathogenesis and NeuroAIDS

Magnetic Colloidal Particles in Combinatorial Thin-Film Gradients for Magnetic Resonance Imaging and Hyperthermia

Preparation and characterization of submicron hybrid magnetic latex particles

Contact Info

Product

Resources

About