Smart Materials Meet Multifunctional Biomedical Devices: Current and Prospective Implications for Nanomedicine

Genchi, Giada Graziana; Marino, Attilio; Tapeinos, Christos; Ciofani, Gianni

doi:10.3389/fbioe.2017.00080

Cited by 53 publications

(27 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In general, this direction has been the motivation for in vivo applications (Erkoc et al, 2018 ). Thus, targeted delivery has benefited by recent in vitro developments in micro/nanorobotic chemotaxis (Peng et al, 2015 ; Shao et al, 2017 ) and material research using stimuli triggered drug release (Genchi et al, 2017 ; Rao et al, 2018 ). For example, magnetically guided nanorobots were used toward the delivery of fluorouracil medication for reducing tumor growth in a mice model.…”

Section: In Vivo Micro/nanorobotic Applicationsmentioning

confidence: 99%

Frontiers of Medical Micro/Nanorobotics: in vivo Applications and Commercialization Perspectives Toward Clinical Uses

Soto

Chrostowski

2018

Front. Bioeng. Biotechnol.

104

View full text Add to dashboard Cite

The field of medical micro/nanorobotics holds considerable promise for advancing medical diagnosis and treatment due to their unique ability to move and perform complex task at small scales. Nevertheless, the grand challenge of the field remains in its successful translation towards widespread patient use. We critically address the frontiers of the current methodologies for in vivo applications and discuss the current and foreseeable perspectives of their commercialization. Although no “killer application” that would catalyze rapid commercialization has yet emerged, recent engineering breakthroughs have led to the successful in vivo operation of medical micro/nanorobots. We also highlight how standardizing report summaries of micro/nanorobotics is essential not only for increasing the quality of research but also for minimizing investment risk in their potential commercialization. We review current patents and commercialization efforts based on emerging proof-of-concept applications. We expect to inspire future research efforts in the field of micro/nanorobotics toward future medical diagnosis and treatment.

show abstract

Section: In Vivo Micro/nanorobotic Applicationsmentioning

confidence: 99%

Frontiers of Medical Micro/Nanorobotics: in vivo Applications and Commercialization Perspectives Toward Clinical Uses

Soto

Chrostowski

2018

Front. Bioeng. Biotechnol.

104

View full text Add to dashboard Cite

show abstract

“…However, due to the complexity of drug distribution processes, the use of individual NPs offered neither optimal, leakage-free delivery of mTHPC to the tumor nor the local release of large amounts of mTHPC. At the same time, multifunctional nanomedicines featuring high drug loading capacity, controllable drug release, and real-time self-monitoring are attracting immense interest due to their potential to improve cancer therapy efficacy [4,5,6].…”

Section: Introductionmentioning

confidence: 99%

Matryoshka-Type Liposomes Offer the Improved Delivery of Temoporfin to Tumor Spheroids

Yakavets

Millard

Lamy

et al. 2019

Cancers

View full text Add to dashboard Cite

The balance between the amount of drug delivered to tumor tissue and the homogeneity of its distribution is a challenge in the efficient delivery of photosensitizers (PSs) in photodynamic therapy (PDT) of cancer. To date, many efforts have been made using various nanomaterials to efficiently deliver temoporfin (mTHPC), one of the most potent photosensitizers. The present study aimed to develop double-loaded matryoshka-type hybrid nanoparticles encapsulating mTHPC/cyclodextrin inclusion complexes in mTHPC-loaded liposomes. This system was expected to improve the transport of mTHPC to target tissues and to strengthen its accumulation in the tumor tissue. Double-loaded hybrid nanoparticles (DL-DCL) were prepared, characterized, and tested in 2D and 3D in vitro models and in xenografted mice in vivo. Our studies indicated that DL-DCL provided deep penetration of mTHPC into the multicellular tumor spheroids via cyclodextrin nanoshuttles once the liposomes had been destabilized by serum proteins. Unexpectedly, we observed similar PDT efficiency in xenografted HT29 tumors for liposomal mTHPC formulation (Foslip®) and DL-DCL.

show abstract

“…In recent decades, hybrid nanomaterials have been intensively investigated in the field of nanomedicine,1–3 diagnosis,4 and imaging 5,6. The consolidation of several functional materials into nanocomposites makes up new opportunities in order to improve a variety of emerging applications of hybrid nanomaterials 7–9…”

Section: Introductionmentioning

confidence: 99%

<p>Design and Synthesis of Gold-Gadolinium-Core-Shell Nanoparticles as Contrast Agent: a Smart Way to Future Nanomaterials for Nanomedicine Applications</p>

Aouidat¹,

Boumati²,

Khan³

et al. 2019

IJN

View full text Add to dashboard Cite

IntroductionThe development of biopolymers for the synthesis of Gd(III) nanoparticles, as therapeutics, could play a key role in nanomedicine. Biocompatible polymers are not only used for complex monovalent biomolecules, but also for the realization of multivalent active targeting materials as diagnostic and/or therapeutic hybrid nanoparticles. In this article, it was reported for the first time, a novel synthesis of Gd(III)–biopolymer–Au(III) complex, acting as a key ingredient of core-shell gold nanoparticles (Gd(@AuNPs).Material and methodsThe physical and chemical evaluation was carried out by spectroscopic analytical techniques (Raman spectroscopy, UV-visible and TEM). The theoretical characterization by DFT (density functional theory) analysis was carried out under specific conditions to investigate the interaction between the Au and the Gd precursors, during the first nucleation step. Magnetic features with relaxivity measurements at 7T were also performed as well as cytotoxicity studies on hepatocyte cell lines for biocompatibility studies. The in vivo detailed dynamic biodistribution studies in mice to characterize the potential applications for biology as MRI contrast agents were then achieved.ResultsPhysical–chemical evaluation confirms the successful design and reaction supposed. Viabilities of TIB-75 (hepatocytes) cells were evaluated using Alamar blue cytotoxic tests with increasing concentrations of nanoparticles. In vivo biodistribution studies were then accomplished to assess the kinetic behavior of the nanoparticles in mice and characterize their stealthiness property after intravenous injection.ConclusionWe demonstrated that Gd@AuNPs have some advantages to display hepatocytes in the liver. Particularly, these nanoconjugates give a good cellular uptake of several quantities of Gd@NPs into cells, while preserving a T1 contrast inside cells that provide a robust in vivo detection using T1-weighted MR images. These results will strengthen the role of gadolinium as complex to gold in order to tune Gd(@AuNPs) as an innovative diagnostic agent in the field of nanomedicine.

show abstract

Smart Materials Meet Multifunctional Biomedical Devices: Current and Prospective Implications for Nanomedicine

Cited by 53 publications

References 80 publications

Frontiers of Medical Micro/Nanorobotics: in vivo Applications and Commercialization Perspectives Toward Clinical Uses

Frontiers of Medical Micro/Nanorobotics: in vivo Applications and Commercialization Perspectives Toward Clinical Uses

Matryoshka-Type Liposomes Offer the Improved Delivery of Temoporfin to Tumor Spheroids

<p>Design and Synthesis of Gold-Gadolinium-Core-Shell Nanoparticles as Contrast Agent: a Smart Way to Future Nanomaterials for Nanomedicine Applications</p>

Contact Info

Product

Resources

About