Smart MXene‐based bioelectronic devices as wearable health monitor for sensing human physiological signals

Abstract

Biosafe wearable healthcare monitor has attracted significant attention owing to their applicability to wearable electronics. However, the narrow sensing range and poor response limit the application of flexible devices for comprehensive monitoring of human health‐related physiological signals (i.e., pulse diagnosis). Critical challenges remain in the development of biocompatible materials and the design of flexible bio‐integrated platforms for these purposes, targeting performance approaching those of conventional wafer‐based technologies and long‐term operational stability. In this context, this work presents a robust and flexible MXene/polydopamine (PDA)‐composite‐film‐based pressure sensor in a portable/wearable fashion, which establishes a unique intercalated spherical‐like PDA molecules structure, thereby resulting in excellent sensing performance. The MXene/PDA‐based pressure sensor has sensitivity of up to 138.8 kPa−1 in the pressure range of 0.18–6.20 kPa with fast response and recovery speed (t1 < 100 ms; t2< 50 ms). Associated embodiment involves real‐time precise measurements of a variety of health‐related physiological signals, ranging from wrist pulse, to finger motions, to vocalization and to facial expressions, with high sensitivity and accuracy. Studies on human subjects establish the clinical significance of these devices for future opportunities of health monitoring and intelligent control to predict and diagnose diseases.

Tailored MXenes and graphene as efficient telemedicine platforms for personalized health wellness

“…11 [left side (a–g)] developed a highly durable and adaptable pressure sensor utilizing a composite film of MXene and polydopamine (PDA) for future clinical contexts. 113 The sensor boasts a distinctive structure integrating spherical PDA molecules, leading to exceptional sensing capabilities. With a sensitivity of 138.8 kPa within the pressure range of 0.18–6.20 kPa with rapid response and recovery times ( t 1 < 100 ms; t 2 < 50 ms), it proves ideal for portable and wearable applications.…”

“…(a 0)-(c 0 ) A real time application of the strain sensor in a hospital setting for continues health monitoring of a patient depicting the telemedicine approach. Reproduced with permission 113. Copyright 2023, Wiley.…”

Green Synthesis and Biosafety Assessment of MXene

“…Thanks to the ingenious synthesis methods of MXene, its chemical structure contains both atomic layers and rich chemical functional groups. [16][17][18][19] So MXene has metallic conductivity and hydrophilicity, as well as highly attractive electronic, magnetic, and optical properties, which make MXene a new favorite in the energy, [20] sensors [21][22][23] especially in biomedical field. [24,25] For example, due to the remarkable near-infrared absorption ability of some MXene, it is beneficial to realize photothermal therapy and synergistic cancer therapy.…”

Neuromodulatory Compensation of Cortical Neural Activity on Electrodeposited Pt/Ir Modified Microelectrode Arrays for Temperature Transients

“…16 The formation of nanocomposites facilitates synergistic interactions among different nanomaterials, which enhances charge transfer kinetics, modulates surface reactivity, and optimizes electron distribution. 17,18 Pt/Ir nanocomposites, in particular, are favored in brain−computer interfaces due to their exceptional biocompatibility and stability. 19 Although electrodeposited Pt/Ir is seldom utilized in neuronal cultures, this method ensures enhanced nanostructure and high performance of microelectrodes.…”

“…The application of nanomaterials in the modification of biosensors has become ubiquitous, , enhancing electrochemical performance through organic nanoparticles including nanozymes and conductive polymers , as well as inorganic nanoparticles such as metallic, semiconducting, and carbon-based nanoparticles . The formation of nanocomposites facilitates synergistic interactions among different nanomaterials, which enhances charge transfer kinetics, modulates surface reactivity, and optimizes electron distribution. , Pt/Ir nanocomposites, in particular, are favored in brain–computer interfaces due to their exceptional biocompatibility and stability . Although electrodeposited Pt/Ir is seldom utilized in neuronal cultures, this method ensures enhanced nanostructure and high performance of microelectrodes .…”