Smart nanocomposite hydrogels based on azo crosslinked graphene oxide for oral colon-specific drug delivery

Hou, Lin; Shi, Yuyang; Jiang, Guixiang; Liu, Wei; Han, Ho Jae; Feng, Qianhua; Ren, Junxiao; Yuan, Yujie; Wang, Yongchao; Shi, Jinjin; Zhang, Zhenzhong

doi:10.1088/0957-4484/27/31/315105

Cited by 50 publications

(21 citation statements)

References 45 publications

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“…The antibacterial activity of GO photolyzed under simulated sunlight was studied recently by Hou et al [ 80 ]. To induce phototransformation of GO, they irradiated the samples after the preparation under simulated sunlight for different time periods.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Comprehensive Application of Graphene: Emphasis on Biomedical Concerns

2019

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HIGHLIGHTS• The introduction of graphene will certainly uncover new advanced materials, and many more future technologies will become realistic in the forthcoming years.• The present review article includes more recent publications about the biomedical application and cellular interaction of graphene. It is also updated with modern approaches such as use of graphene inks for 3D printing application.• Moreover, the importance of protein corona in modulating the cellular interaction, which was overlooked in previous review publications, is also included in this article.• The possible biological outcomes and toxicity when graphene is exposed to living organisms at the cellular and organ level are explained.ABSTRACT Graphene, sp 2 hybridized carbon framework of one atom thickness, is reputed as the strongest material to date. It has marked its impact in manifold applications including electronics, sensors, composites, and catalysis. Current state-of-the-art graphene research revolves around its biomedical applications. The two-dimensional (2D) planar structure of graphene provides a large surface area for loading drugs/biomolecules and the possibility of conjugating fluorescent dyes for bioimaging. The high near-infrared absorbance makes graphene ideal for photothermal therapy. Henceforth, graphene turns out to be a reliable multifunctional material for use in diagnosis and treatment.It exhibits antibacterial property by directly interacting with the cell membrane. Potential application of graphene as a scaffold for the attachment and proliferation of stem cells and neuronal cells is captivating in a tissue regeneration scenario. Fabrication of 2D graphene into a 3D structure is made possible with the help of 3D printing, a revolutionary technology having promising applications in tissue and organ engineering. However, apart from its advantageous application scope, use of graphene raises toxicity concerns. Several reports have confirmed the potential toxicity of graphene and its derivatives, and the inconsistency may be due to the lack of standardized consensus protocols. The present review focuses on the hidden facts of graphene and its biomedical application, with special emphasis on drug delivery, biosensing, bioimaging, antibacterial, tissue engineering, and 3D printing applications.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Comprehensive Application of Graphene: Emphasis on Biomedical Concerns

2019

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“…One of these approaches has been the encapsulation of curcumin with the aim to increase its solubility, stability and bioavailability in physiological conditions [81]. Curcumin has been integrated on different systems, such as folic acid tagged aminated starch/ZnO coated iron oxide nanoparticles [82], curcumin incorporating with Fe 3 O 4 loaded into: polyethylene glycol-poly lactic acid-co-glycolic acid (PLGA-PEG) co-polymer [83], disulfide-linked hydrophobic backbone of a PEGylated amphiphilic diblock copolymer (biotin poly(ethylene glycol)-poly(curcumin-dithio dipropionic acid)) conjugated with chemotherapeutic agent paclitaxel [84], superparamagnetic iron oxide nanoparticles [85], graphene oxides nanocomposites [86], curcumin-loaded graphene quantum dots [87], cyclodextrin-metal organic frameworks [88], different polymeric nanoparticles like: poly(ethylene glycol)-poly(ε-caprolactone) (PEG-PCL) copolymer [89], PEG-β-cyclodextrin, curcumin solid lipid nanoparticles [90], PCL stabilized with C18-HbPG [91], cholesterol-conjugated poly(D,L-lactide)-based micelles [92] and curcumin-loaded embryonic stem cell exosomes [93]; sequential delivery of curcumin-docosahexaenoic acid loaded carriers towards promoting neuronal survival [94]. We will focus on those applied to retinal pathologies.…”

Section: Encapsulationmentioning

confidence: 99%

Curcumin as a Therapeutic Option in Retinal Diseases

et al. 2020

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The retina is subjected to oxidative stress due to its high vascularization, long time light exposition and a high density of mitochondria. Oxidative stress can lead to pathological processes, like cell apoptosis, angiogenesis and inflammation ending in retinal pathologies. Curcumin, a major bioactive component obtained from the spice turmeric (Curcuma longa) rhizome has been used for centuries in Asian countries for cooking and for curing all kinds of diseases like dysentery, chest congestion and pain in general, due to its antioxidant effects. Curcumin prevents the formation of reactive oxygen species and so it is a good protective agent. Curcumin has shown also anti-inflammatory, and antitumor properties. Curcumin is a natural product, which can be a therapeutic option in a variety of retinal diseases due to its pleiotropic properties. Some drawbacks are its poor solubility, bioavailability and lack of stability at physiological conditions; which have been shown in curcumin skeptical publications. In this review, we provide some lights and shadows on curcumin administration on the major retinal pathologies.

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“…Hou et al [122] designed and obtained nanocomposite hydrogels based on azo cross-linked graphene oxide that is suitable for providing specific colon drug delivery after oral administration. This approach could be used to administrate different drugs, thanks to the nanocomposite hydrogels versatility and biocompatibility.…”

Section: Oral Cdds Following a Dual Or Combined Approachmentioning

confidence: 99%

New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy

Teruel

González‐Álvarez

Bermejo

et al. 2020

IJMS

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Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and less systemic adverse effects, as consequence of less/null drug absorption in small intestine. This review focused on the reported contributions in the last four years to improve the effectiveness of treatments of inflammatory bowel diseases. The work concludes that there has been an increase in the development of CDDS in which pH, specific enzymes, reactive oxygen species (ROS), or a combination of all of these triggers the release. These delivery systems demonstrated a therapeutic improvement with fewer adverse effects. Future perspectives to the treatment of this disease include the elucidation of molecular basis of IBD diseases in order to design more specific treatments, and the performance of more in vivo assays to validate the specificity and stability of the obtained systems.

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Smart nanocomposite hydrogels based on azo crosslinked graphene oxide for oral colon-specific drug delivery

Cited by 50 publications

References 45 publications

Comprehensive Application of Graphene: Emphasis on Biomedical Concerns

Comprehensive Application of Graphene: Emphasis on Biomedical Concerns

Curcumin as a Therapeutic Option in Retinal Diseases

New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy

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