Smart Nanomaterials for Tumor Targeted Hyperthermia

Jagtap, Jaidip; Parchur, Abdul K.; Sharma, Gayatri

doi:10.1016/b978-0-12-817830-0.00003-5

Cited by 4 publications

(5 citation statements)

References 115 publications

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“…During the formation of the stock of ATMP and TC (J20), the release of anticancer drug at the tumor site is represented by the small gray box (drug delivery). Then, under alternating MF (J38), magnetite NBMs on the tumor site (J22) can transform the electromagnetic energy into heat (hyperthermia process) causing localized heating of the TC (J24) and thus triggering the commitment to apoptosis of cancer cells (Goya et al, 2008;Jagtap et al, 2020) and their death (J29). The apoptosis process of TC can be generated not only as a consequence of heating of tumor site but also activated by ROS production (Hou et al, 2014) (J25).…”

Section: System Thinking Diagram Of Theranostic Approach Combined With Personalized Nanomedicine Of Solid Tumors Using Magnetite Nbmsmentioning

confidence: 99%

Using Stock-Flow Diagrams to Visualize Theranostic Approaches to Solid Tumors in Personalized Nanomedicine

Cazzagon

Romano

Gonella

2021

Front. Bioeng. Biotechnol.

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Personalized nanomedicine has rapidly evolved over the past decade to tailor the diagnosis and treatment of several diseases to the individual characteristics of each patient. In oncology, iron oxide nano-biomaterials (NBMs) have become a promising biomedical product in targeted drug delivery as well as in magnetic resonance imaging (MRI) as a contrast agent and magnetic hyperthermia. The combination of diagnosis and therapy in a single nano-enabled product (so-called theranostic agent) in the personalized nanomedicine has been investigated so far mostly in terms of local events, causes-effects, and mutual relationships. However, this approach could fail in capturing the overall complexity of a system, whereas systemic approaches can be used to study the organization of phenomena in terms of dynamic configurations, independent of the nature, type, or spatial and temporal scale of the elements of the system. In medicine, complex descriptions of diseases and their evolution are daily assessed in clinical settings, which can be thus considered as complex systems exhibiting self-organizing and non-linear features, to be investigated through the identification of dynamic feedback-driven behaviors. In this study, a Systems Thinking (ST) approach is proposed to represent the complexity of the theranostic modalities in the context of the personalized nanomedicine through the setting up of a stock-flow diagram. Specifically, the interconnections between the administration of magnetite NBMs for diagnosis and therapy of tumors are fully identified, emphasizing the role of the feedback loops. The presented approach has revealed its suitability for further application in the medical field. In particular, the obtained stock-flow diagram can be adapted for improving the future knowledge of complex systems in personalized nanomedicine as well as in other nanosafety areas.

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Section: System Thinking Diagram Of Theranostic Approach Combined With Personalized Nanomedicine Of Solid Tumors Using Magnetite Nbmsmentioning

confidence: 99%

Using Stock-Flow Diagrams to Visualize Theranostic Approaches to Solid Tumors in Personalized Nanomedicine

Cazzagon

Romano

Gonella

2021

Front. Bioeng. Biotechnol.

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“…Hyperthermia treatment transfers energy to subjected tissue by utilizing an outer facility such as electromagnetic waves or light radiation. Combination of hyperthermia with anticancer drugs, chemotherapy, radiation therapy, surgery, gene therapy, and immunotherapy can perform a better cancer treatment and enhance the effectiveness [113] . Ultrasound, microwaves, radiofrequency infrared radiation, magnetically excitable thermos seeds, and tubes with hot water are current available treatments techniques for hyperthermia induction.…”

Section: Magneto/photothermally Responsive Nanomaterials For Controllmentioning

confidence: 99%

“…In addition to iron oxide, a small percentage of particles are manufactured by nickel, cobalt, or other magnetic materials in order to get better result in heating efficiency; however, their complexity in synthesis, low biocompatibility and chemical instability prevent them from utilizing widely (limited application) even though they have larger SAR values (up to 720 W/g) compering to all the iron oxide. Combination of Magnetic nanoparticle with materials like mesoporous silica nanoparticles, graphene oxide (GO), polymeric nanoparticles and photoactive materials results in hybrid materials with multifunctionality [55b,113, 115] . For example Graphene oxide‐Fe 3 O 4 nanoparticle‐based nanocomposites are studied for many biomedical applications like magnetic hyperthermia, drug delivery, and MRI (Magnetic Resonance Imaging) contrast agents [113,115b] …”

Section: Magneto/photothermally Responsive Nanomaterials For Controllmentioning

confidence: 99%

“…Combination of Magnetic nanoparticle with materials like mesoporous silica nanoparticles, graphene oxide (GO), polymeric nanoparticles and photoactive materials results in hybrid materials with multifunctionality [55b,113, 115] . For example Graphene oxide‐Fe 3 O 4 nanoparticle‐based nanocomposites are studied for many biomedical applications like magnetic hyperthermia, drug delivery, and MRI (Magnetic Resonance Imaging) contrast agents [113,115b] …”

Section: Magneto/photothermally Responsive Nanomaterials For Controllmentioning

confidence: 99%

“…Brownian relaxation happens when particles try to realign themselves with the change in magnetic field which cause heat generation from physical rotation of particles in a supporting medium. When these MNPs are located in cells or on their membranes, Brownian relaxation can be in vitro and in vivo experiments [113] …”

Section: Magneto/photothermally Responsive Nanomaterials For Controllmentioning

confidence: 99%

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Photo‐ and Magnetothermally Responsive Nanomaterials for Therapy, Controlled Drug Delivery and Imaging Applications

et al. 2020

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Hyperthermia generates heat as a cure for illness and it is not a chemical treatment. Nanomaterials are supposed to provide novel mechanisms to tackle photothermal and magnetothermal problems, with the potential also to deal with specific approaches to care. The present review outlines recent developments in the field of photothermal and magnetothermal responsive nanomaterials and the photothermal approach mechanism over the last years. These photo/magnetothermal nanomaterials are classified into gold nanostructures (various shapes), carbon nanomaterials (CNTs, fullerene, carbon quantum dots, and graphene), inorganic nanomaterials (Fe, Pt, Pd, Bi, MOF, MoSe2, inorganic quantum dots, etc.) and organic nanoparticles (PLGA (Poly Lactic‐co‐Glycolic Acid) and other nanopolymers). Different groups may be placed together to improve the potential of the photothermal/magnetothermal effects, treatments, drug delivery, and imaging. The review also describes synthesis strategies for photothermal/magnetothermal nanomaterials, physicochemical characterization, the role of size, size distribution, shape, and surface coating of nanomaterials, challenges, and future scopes of photothermal/magnetothermal responsive nanomaterials for therapy, controlled drug delivery, and imaging applications. The recent development in nanomaterial has shown great potential for tumor diagnostic and therapeutic applications in hyperthermia. Magnetic hyperthermia (also called thermal therapy or thermotherapy) is a type of cancer treatment in which body tissue is exposed to high temperatures (up to 41 °C) in presence of a magnetic field. Research has shown that high temperatures can damage and kill cancer cells, usually with minimal injury to normal tissues. By killing cancer cells and damaging proteins and structures within cells, hyperthermia can necrotize tumor cells. This treatment can be local, regional, or whole‐body hyperthermia, depending on the extent of the area being treated. Hyperthermia can be combined with anticancer drugs or chemotherapy to enhance cancer treatment. In this article, we have discussed recent nanomaterials utilized for this treatment, mechanism, and synthesis methods.

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Design and Self Assembly of Tri-Terpene Peptide Conjugates and Their Interactions with EGFR and EGFR Mutant Receptors: An In Silico and In Vitro Study

Rico,

Goncalves,

Hunt

et al. 2023

Int J Pept Res Ther

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Smart Nanomaterials for Tumor Targeted Hyperthermia

Cited by 4 publications

References 115 publications

Using Stock-Flow Diagrams to Visualize Theranostic Approaches to Solid Tumors in Personalized Nanomedicine

Using Stock-Flow Diagrams to Visualize Theranostic Approaches to Solid Tumors in Personalized Nanomedicine

Photo‐ and Magnetothermally Responsive Nanomaterials for Therapy, Controlled Drug Delivery and Imaging Applications

Design and Self Assembly of Tri-Terpene Peptide Conjugates and Their Interactions with EGFR and EGFR Mutant Receptors: An In Silico and In Vitro Study

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