Smart Nanoparticles for Breast Cancer Treatment Based on the Tumor Microenvironment

Luo, Xiao; Zhang, Qi; Chen, Hongbo; Hou, Kai; Zeng, Ning; Wu, Yiping

doi:10.3389/fonc.2022.907684

Cited by 10 publications

(7 citation statements)

References 88 publications

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“…In the context of the lung tumor microenvironment (TME), these stimuli become particularly relevant due to the unique physiological and biochemical properties of cancerous tissue. [ 26 ] TME plays a crucial role in the development and progression of cancer. Studies examining lung cancer from the perspective of TME have revealed a complex scenario in which tumor angiogenesis, soluble factors, and TME cells themselves all contribute to tumor growth.…”

Section: Role Of Smart Nps In Lung Cancer Therapymentioning

confidence: 99%

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Shahrivar,

Fakhr,

Abbasgholinejad

et al. 2023

Advanced Therapeutics

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Lung cancer remains the leading cause of cancer‐related deaths worldwide, and conventional treatments for the disease often fall short. Smart nanoparticles (NPs) are emerging as a promising strategy for the treatment of lung cancer, owing to their ability to selectively deliver therapeutic agents to cancer cells while minimizing off‐target effects. Smart NPs can respond to specific stimuli such as changes in pH, temperature, or enzymes, allowing them to release their cargo only when triggered. Among the various types of smart NPs, lipid‐based NPs, including liposomes, solid lipid nanoparticles, cubosomes, and extracellular vesicles, have garnered the highest interest due to their biocompatibility, low toxicity, and versatility in encapsulating a wide variety of drugs and genetic material. This review discusses the current status of smart lipid‐based NPs in lung cancer treatment, including recent advances in targeting strategies, stimuli‐responsive NPs, and combination therapies. The challenges and opportunities associated with translating smart lipid‐based NPs for lung cancer treatment into clinical applications are also discussed. This review highlights the potential of smart lipid‐based NPs to revolutionize lung cancer treatment and improve patient outcomes.

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Section: Role Of Smart Nps In Lung Cancer Therapymentioning

confidence: 99%

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Shahrivar,

Fakhr,

Abbasgholinejad

et al. 2023

Advanced Therapeutics

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“…In addition, the toxicity should be reduced, or the immunogenicity minimized [17][18][19]. This fact is highly associated with non-selective or non-specific damage to healthy tissue [20,21]. Appropriate drug delivery is a key component to achieving an efficient drug recovery response.…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive Behavior Defines the Features of Poly(N-isopropylacrylamide)/Magnetite Nanoparticles for Cancer Management

et al. 2023

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This paper reports the preparation and characterization of thermosensitive poly(N-isopropylacrylamide) (PNIPAM)/magnetite nanoparticles in various conditions. The nanoprecipitation conditions address the impact of the temperature on PNIPAM/magnetite nanoparticle features due to the thermosensitive character of PNIPAM. Hybrid nanoparticles with desired features (size, size distribution, agglomeration, and release profile) are prepared by nanoprecipitation in non-solvent (acetone) at various temperatures. These nanoparticles are targeted as nanocarriers to deliver doxorubicin in breast cancer cells. Therefore, three temperatures, below the LCST (lower critical solution temperature), around the LCST, and above the LCST, were chosen as the main parameters within nanoprecipitation. Besides temperature, another major parameter drives the nanoparticles’ features: polymer solution concentration. In this regard, two variable parameters were used to study the characteristics of developed hybrid nanoparticles. After preparation, the hybrid nanoparticles were subjected to morphological and size distribution investigation by SEM and DLS. The doxorubicin loading and release measurements were also performed to reveal the behavior of the nanoparticles. Finally, the unloaded and loaded hybrid nanoparticles were biologically assessed within a cancer cells line (MCF7) in terms of biocompatibility, cancer cell viability, and cell morphology.

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“…Breast cancer (BC) is one of the most prevalent types of cancer in women throughout the world [ 1 ]. The incidence of BC has been growing at a 0.3% yearly pace in recent years, with 2.3 million new cases expected in 2020 and a considerable rise in mortality from 1990 to 2015 [ 2 ]. It is caused by estrogen/progesterone receptor mutations [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles combined baker’s yeast as a successful approach for breast cancer treatment

Elwakkad

Din

Saleh

et al. 2023

Journal of Genetic Engineering and Biotechnology

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Background Saccharomyces cerevisiae (S. cerevisiae) has been demonstrated in vitro to sensitize several breast cancer cell lines and to be a safe, non-toxic drug with anti-skin cancer action in mice. Furthermore, plasmonic photothermal treatment using gold nanorods has been authorized as a novel method for in vitro and in vivo cancer therapy. Results When compared to tumor-free rats, the treatment with S. cerevisiae conjugated to gold nanospheres (GNSs) lowered Bcl-2 levels while increasing FasL, Bax, cytochrome c, and caspases 8, 9, and 3 levels. Histopathological results showed changes reflecting the ability of nanogold conjugated heat-killed yeast to induce apoptosis is greater than heat-killed yeast alone as the nanogold conjugated with heat-killed yeast showed no tumor, no hyperplasia, no granulation tissue formation, no ulceration, and no suppuration. Nanogold conjugated with heat-killed yeast-treated breast cancer group displayed normal levels of ALT and AST, indicating relatively healthy hepatic cells. Conclusion Our results proved that nanogold conjugated heat-killed yeast can initiate apoptosis and can be used as a safe non-invasive method for breast cancer treatment more effectively than the yeast alone. This, in turn, gives us new insight and a future hope for the first time that breast cancer can be treated by non-invasive, simple, safe, and naturally originated method and achieves a hopeful treatment and a novel method for in vivo cancer therapy.

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Smart Nanoparticles for Breast Cancer Treatment Based on the Tumor Microenvironment

Cited by 10 publications

References 88 publications

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Thermosensitive Behavior Defines the Features of Poly(N-isopropylacrylamide)/Magnetite Nanoparticles for Cancer Management

Gold nanoparticles combined baker’s yeast as a successful approach for breast cancer treatment

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