Smart NIR-light and pH responsive doxorubicin-loaded GNRs@SBA-15-SH nanocomposite for chemo-photothermal therapy of cancer

Abstract

We designed novel biocompatible nanocomposite composed of gold nanorods coated with rod-like mesoporous silica SBA-15-SH particles, (GNRs@SBA-15-SH) as a new synergistic therapeutic device to deliver heat and drug to cancer cells for tumor eradication. For this purpose, doxorubicin (DOX) was loaded into GNRs@SBA-15-SH nanocomposites and studied their photothermal therapy, chemotherapy and the combined effect on the ablation of A549 cells in vitro using human lung cancer cells, A549. The results demonstrate the high photothermal efficacy of gold nanorods loaded into the nanocomposite, the thermo-responsive properties of GNRs@SBA-15-SH, the high loading capacity of DOX into the GNRs@SBA-15-SH and its biocompatibility. Synergistic chemo-photothermal of the GNRs@SBA-15-SH/DOX nanocomposite in the eradication of cancer cells under laser irradiation (808 nm), demonstrates the high potential of therapeutic efficacy of this combined therapy over monotherapies.

NIR/pH Dual-Responsive DOX-Loaded AuNRs@S-β-CD Nanocomposite for Highly Effective Chemo-photothermal Synergistic Therapy against Lung Cancer Cells

“…Therefore, the use of two methods or different types of methods of treatment or a method to boost another method of treatment has developed a new trend in cancer treatment . The combination of chemotherapy and photothermal therapy can be more effective than single therapy because hyperthermia was exhibited to result in higher and faster drug release into a tumor, and improvement of the anticancer effect of chemotherapeutic drugs such as doxorubicin. , Therefore, gold nanorods coated with DNA, proteins, stimulus-responsive polymers, porous metal organic frameworks, and porous silica with large loading capacities have been expanded to assess the effect of photothermal-chemotherapy …”

“…20 The combination of chemotherapy and photothermal therapy can be more effective than single therapy because hyperthermia was exhibited to result in higher and faster drug release into a tumor, 21 and improvement of the anticancer effect of chemotherapeutic drugs such as doxorubicin. 22,23 Therefore, gold nanorods coated with DNA, proteins, stimulus-responsive polymers, porous metal organic frameworks, and porous silica with large loading capacities have been expanded to assess the effect of photothermal-chemotherapy. 24 The key to chemo-photothermal combined therapy depends on the photothermal agents; photothermal therapy (PTT) can be acquired simultaneously with laser light irradiation, leading to chemo-photothermal therapy.…”

Enhanced photothermal heating and combination therapy of gold nanoparticles on a breast cell model

“…Dox-AuNPs nanocomposite was made according to Vaithilingam method [ 16 ]. 1 ml of different concentrations of Dox (10, 20, 30, 40 μM) were mixed drop-wise with 1 ml of 0.125 mM of AuNPs with continues stirring and sonicate for 10 min until deep red becomes blue.…”

Membrane-wrapped nanoparticles for photothermal cancer therapy

“…Excitingly, PTT mediated by silica core/gold shell "nanoshells" (also known as auroshells) has entered human clinical trials, with promising results reported [5][6][7]. Moreover, preclinical studies have shown that PTT can greatly enhance the efficacy of chemotherapy [8][9][10][11], radiotherapy [12][13][14] and immunotherapy [15,16] when deployed in tandem, indicating PTT has great promise to improve patient care in the decades to come.…”