Smart “on-off-on” fluorescent switches for drug visual loading and responsive delivery

Gong, Peiwei; Zhang, Lei; Peng, Jingyi; Li, Shuohan; Chen, Junfeng; Liu, Xicheng; Peng, Hao; Liu, Zhe; You, Jinmao

doi:10.1016/j.dyepig.2019.107893

Cited by 29 publications

(15 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After incubation A549 cells (cancer cells overexpressed HA receptors incubated in Dulbecco's modified Eagle medium with 10 % fetal bovine serum) with FGO‐ADH‐Fe 3 O 4 +DOX and FGO‐ADH‐HA‐Fe 3 O 4 +DOX under the same conditions, it was found that the intracellular DOX signal intensity (green color) of FGO‐ADH‐HA‐Fe 3 O 4 +DOX (Figure 7a) was about three times higher than that of FGO‐ADH‐Fe 3 O 4 +DOX (Figure 7b), revealing that modification of HA could greatly improve the targeting effect of the composite. Moreover, it was also observed that the DOX signal well overlapped that of 4′,6‐diamidino‐2‐phenylindole (DAPI, a molecular to label nucleus), [38] and this indicated that DOX could readily release from the composite and act on the nucleus to kill cancer cells. The good targeting effect was also further confirmed in the cell experiments in Figure 8.…”

Section: Resultsmentioning

confidence: 97%

Fluorescence Turn‐off Magnetic Fluorinated Graphene Composite with High NIR Absorption for Targeted Drug Delivery

et al. 2020

Self Cite

View full text Add to dashboard Cite

Although fluorinated graphene/Fe3O4 composites exhibit a unique structure and chemical surface, and thus hold great potential in many fields, their effective synthesis has remained a headache because of poor dispersity and easy aggregation behavior. Herein, we report a novel method to prepare hyaluronic acid (HA)‐modified fluorinated graphene with a well‐defined structure and good solubility in various media, and this then allowed us for the first time to controllably deposit magnetic Fe3O4 nanoparticles onto the sheets with designed ratio and contents. This strategy further guaranteed a multifunctional composite that possessed HA and magnetism‐induced dual‐targeting effect towards cancer cells and high near‐infrared absorption for photothermal therapy (PTT). Moreover, this composite also showed an effective turn‐off fluorescence effect for the anticancer drug doxorubicin, allowing us to visually monitor the drug loading procedure. Anticancer experiments indicated that such a successful combination of PTT and chemotherapy with special selectivity toward cancer cells exhibited a much better therapeutic effect than single therapy.

show abstract

Section: Resultsmentioning

confidence: 97%

Fluorescence Turn‐off Magnetic Fluorinated Graphene Composite with High NIR Absorption for Targeted Drug Delivery

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Compared to the XRD pattern of FCO, FA-BSA/FCO, and Ag, the XRD pattern of FA-BSA/FCO/Ag obviously changed. The peak of 2θ = 23.5° for FA-BSA/FCO/Ag could be indexed as the (002) plane of graphitic carbon that reflected the anisotropic carbon structure. , The XRD pattern of FA-BSA/FCO/Ag also exhibited peaks at 38.1, 44.1, 64.4, and 77.3°, resulting from (111), (200), (220), and (311) crystallographic planes of the face-centered cubic silver nanoparticles, respectively [JCPDS no. 04-0783].…”

Section: Resultsmentioning

confidence: 99%

Rational Construction of Fluorescence Turn-Off Fluorinated Carbon Fiber/Ag Composites and Their Anticancer and Antibacterial Activities

Wang

Peng

Huang

et al. 2021

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

Although fluorinated carbon fiber/Ag composites possess unique structure and special charge distribution and exhibit great potential in numerous fields, their synthesis has long been a headache because of inert chemistry bonds, low surface energy, and easy aggregation. Herein, we first demonstrate a fresh concept of constructing the nanoscale hydrosoluble fluorinated carbon fiber oxide (FCO)/Ag composite and then integrate it as a highly effective targeting nanocarrier and photothermal therapy and antibacterial agent. Chemical introduction of oxygen allows us to controllably deposit Ag nanoparticles (AgNPs) for the first time and further facilitates surface modification with folic acid prelinked bovine serum albumin to induce targeted endocytosis toward tumor cells. The structure adjustment of FCO into nanosize and the decoration of AgNPs endow the composite with much better photothermal property than fluorinated carbon materials, and FCO/Ag also serves as an effective fluorescence quencher for doxorubicin, realizing visual monitor of drug adsorption processes by "turn-off" fluorescence. Meanwhile, both in vitro and in vivo results reveal greatly improved cancer therapeutic effects than single therapy. What is more is that the synergistic interactions of lipophilic fluorine and AgNPs also ensure highly effective antibacterial activity. Our study integrates FCO/Ag as an emerging drug carrier that exhibits excellent targeted efficiency and high photothemal property and reports its unprecedented experimental example in both antibacterial-and anticancer-combined chemo-photothermal therapy.

show abstract

“…On the contrary, CDs distribute in the cytoplasm (Figure b) with a negligible change of fluorescence intensity (Figure d). Since fluorinated biomaterials − have high affinity for various cell membranes (such as endosome/lysosome membrane), which can pass through the lipid bilayer of membranes and enter into nucleus, , the nucleus-targeting function of FCDs might be attributed to the introduction of fluorine.…”

Section: Resultsmentioning

confidence: 99%

“…In order to demonstrate the potential application of FCDs as carriers to construct nanocomposites, DOX was used as a model drug to assemble with FCDs and fabricate FCD-DOX hybrids via simple noncovalent bond π–π stacking interaction. ,, Different mass ratios of FCDs to DOX were used to construct FCD-DOX hybrids and the UV–vis absorption and PL spectra of each sample in DMF were characterized. As shown in Figure S2a,b in SI, the maximum intensities of UV–vis absorption and PL spectra were observed when the mass ratio of FCDs to DOX wAs 2:3, indicating that this is the optimum mass ratio.…”

Section: Resultsmentioning

confidence: 99%

Fluorine-Doped Carbon Dots with Intrinsic Nucleus-Targeting Ability for Drug and Dye Delivery

Gao

Shi

et al. 2019

Bioconjugate Chem.

View full text Add to dashboard Cite

A new type of fluorine-doped carbon dots (FCDs) with the nucleus-targeting capability was prepared and utilized as a promising candidate for drug and dye delivery. Doxorubicin (DOX) and boron dipyrromethene (BODIPY) was used as a model drug and dye, respectively, to construct FCD-DOX and FCD-BODIPY nanocomposites via coassembly with FCDs. The results demonstrate that FCDs can remarkably increase the cellular uptake and delivery of DOX and BODIPY. This work developed a convenient strategy to construct CDs-based nanohybrids for nucleus-targeted bioimaging and cancer treatment.

show abstract

Smart “on-off-on” fluorescent switches for drug visual loading and responsive delivery

Cited by 29 publications

References 50 publications

Fluorescence Turn‐off Magnetic Fluorinated Graphene Composite with High NIR Absorption for Targeted Drug Delivery

Fluorescence Turn‐off Magnetic Fluorinated Graphene Composite with High NIR Absorption for Targeted Drug Delivery

Rational Construction of Fluorescence Turn-Off Fluorinated Carbon Fiber/Ag Composites and Their Anticancer and Antibacterial Activities

Fluorine-Doped Carbon Dots with Intrinsic Nucleus-Targeting Ability for Drug and Dye Delivery

Contact Info

Product

Resources

About