Smart pH-responsive polyhydralazine/bortezomib nanoparticles for remodeling tumor microenvironment and enhancing chemotherapy

Wang, Rui; Xu, Xiaodan; Li, Dongdong; Zhang, Wei; Shi, Xueying; Xu, Hongxia; Hong, Jianqiao; Yao, Shasha; Liu, Jiwei; Wei, Zhenli; Piao, Ying; Zhou, Zhuxian; Shen, Youqing; Tang, Jianbin

doi:10.1016/j.biomaterials.2022.121737

Cited by 31 publications

(17 citation statements)

References 44 publications

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“…Therefore, it can be predicted that TME will be the main mechanism that hinders the efficacy of immunotherapy for PC for a long time. However, some NDDS has shown the potential to overcome the poor immunotherapeutic efficacy caused by TME: such as NDDS to promote pyroptosis ( Xiao et al, 2021 ; Qiu et al, 2022b ), intelligent stimulus response NDDS ( Bu et al, 2021 ; Tan et al, 2021 ; Wang et al, 2022c ; Mao et al, 2022 ), NDDS with high efficiency of transcytosis ( Wang et al, 2022b ; Wu et al, 2022 ); vaccines based on NDDS ( Banerjee et al, 2019 ; Affandi et al, 2020 ; Liu et al, 2021a ; Tang et al, 2022 ); NDDS of siRNAs targeted immune ( Ghasemi-Chaleshtari et al, 2020 ; Deng et al, 2022a ; Biber et al, 2022 ; Li et al, 2022 ; Yoo et al, 2022 ). The development of multifunctional NDDS with diverse and complementary functions is expected to enhance the efficacy of PC immunotherapy.…”

Section: Discussionmentioning

confidence: 99%

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

et al. 2022

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Background: Nano drug delivery system (NDDS) can significantly improve the delivery and efficacy of drugs against pancreatic cancer (PC) in many ways. The purpose of this study is to explore the related research fields of NDDS for PC from the perspective of bibliometrics.Methods: Articles and reviews on NDDS for PC published between 2003 and 2022 were obtained from the Web of Science Core Collection. CiteSpace, VOSviewer, R-bibliometrix, and Microsoft Excel were comprehensively used for bibliometric and visual analysis.Results: A total of 1329 papers on NDDS for PC were included. The number of papers showed an upward trend over the past 20 years. The United States contributed the most papers, followed by China, and India. Also, the United States had the highest number of total citations and H-index. The institution with the most papers was Chinese Acad Sci, which was also the most important in international institutional cooperation. Professors Couvreur P and Kazuoka K made great achievements in this field. JOURNAL OF CONTROLLED RELEASE published the most papers and was cited the most. The topics related to the tumor microenvironment such as “tumor microenvironment”, “tumor penetration”, “hypoxia”, “exosome”, and “autophagy”, PC treatment-related topics such as “immunotherapy”, “combination therapy”, “alternating magnetic field/magnetic hyperthermia”, and “ultrasound”, and gene therapy dominated by “siRNA” and “miRNA” were the research hotspots in the field of NDDS for PC.Conclusion: This study systematically uncovered a holistic picture of the performance of NDDS for PC-related literature over the past 20 years. We provided scholars to understand key information in this field with the perspective of bibliometrics, which we believe may greatly facilitate future research in this field.

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Section: Discussionmentioning

confidence: 99%

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

et al. 2022

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“…Emerging examples of multifunctional NDDS that induce ICD‐mediated antitumor chemoimmunotherapy are reviewed below based on the types of formulation materials ( Table 1 ). [ 40,80–100 ]…”

Section: Recent Advances Of Ndds For Chemotherapeutic Icd Inducersmentioning

confidence: 99%

“…injection, HDZ, which was released from PHDZ‐BTZ in response to acidic environment, achieved tumor vessel dilation and hypoxia attenuation (as discussed above), facilitating higher accumulation of BTZ in tumor area. [ 85 ] Consequently, BTZ induced ICD‐based antitumor effects, resulting in the suppression of tumor progression in subcutaneous and metastatic breast cancer mouse models, without causing significant systemic toxicity. [ 85 ]…”

Section: Combination Strategy For Icd‐mediated Chemoimmunotherapymentioning

confidence: 99%

Nano Delivery of Chemotherapeutic ICD Inducers for Tumor Immunotherapy

2023

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Immunogenic cell death (ICD, also known as immunogenic apoptosis) of malignant cells is confirmed to activate the host immune system to prevent, control, and eliminate tumors. Recently, a range of chemotherapeutic drugs have been repurposed as ICD inducers and applied for tumor immunotherapy. However, several hurdles to the widespread application of chemotherapeutic ICD inducers remain, namely poor water solubility, short blood circulation, non‐specific tissue distribution, and severe toxicity. Recent advances in nanotechnology and pharmaceutical formulation foster the development of nano drug delivery systems to tackle the aforementioned hurdles and expedite safe, effective, and specific delivery. This review will describe delivery barriers to chemical ICD inducers and highlight recent nanoformulations for these drugs in tumor immunotherapy.

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“…In recent years, researchers have explored numerous strategies to improve BTZ-mediated ICD (Figure 3). In research related to nano-drugs, smart pH-responsive polyhydrazine/BTZ nanoparticles were more effective in inducing ICD of 4T1 cells and inhibiting lung metastasis than BTZ alone (Wang et al, 2022). BTZ combined with radiotherapy can enhance colon cancer cell sensitivity to apoptosis, which can significantly increase the killing effect of tumor-specific CD8⁺ T cells on colon cancer cells, thus effectively inducing anti-tumor immunity (Cacan et al, 2015).…”

Section: Proteasome Inhibitorsmentioning

confidence: 99%

Chemotherapeutic and targeted drugs-induced immunogenic cell death in cancer models and antitumor therapy: An update review

Zhang

Liu

et al. 2023

Front. Pharmacol.

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As traditional strategies for cancer treatment, some chemotherapy agents, such as doxorubicin, oxaliplatin, cyclophosphamide, bortezomib, and paclitaxel exert their anti-tumor effects by inducing immunogenic cell death (ICD) of tumor cells. ICD induces anti-tumor immunity through release of, or exposure to, damage-related molecular patterns (DAMPs), including high mobility group box 1 (HMGB1), calreticulin, adenosine triphosphate, and heat shock proteins. This leads to activation of tumor-specific immune responses, which can act in combination with the direct killing functions of chemotherapy drugs on cancer cells to further improve their curative effects. In this review, we highlight the molecular mechanisms underlying ICD, including those of several chemotherapeutic drugs in inducing DAMPs exposed during ICD to activate the immune system, as well as discussing the prospects for application and potential role of ICD in cancer immunotherapy, with the aim of providing valuable inspiration for future development of chemoimmunotherapy.

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Smart pH-responsive polyhydralazine/bortezomib nanoparticles for remodeling tumor microenvironment and enhancing chemotherapy

Cited by 31 publications

References 44 publications

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

Nano Delivery of Chemotherapeutic ICD Inducers for Tumor Immunotherapy

Chemotherapeutic and targeted drugs-induced immunogenic cell death in cancer models and antitumor therapy: An update review

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