Smart Poly (N-Isopropylacrylamide)-block-Poly (L-Lactide) Nanoparticles for Prolonged Release of Naltrexone

Salehi, Roya; Nowruzi, Keyvan; Salehi, Shahram; Khandaghi, Amir Ahmad; Davaran, Soodabeh; Entezami, Ali Akbar

doi:10.1080/00914037.2013.769227

Cited by 21 publications

(13 citation statements)

References 34 publications

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“…[1] Advantages of developing such systems include increasing patient compliance and comfort, reducing the complications of side effects and ease of administration. [2] Various delivery systems have been examined in other studies such as emulsions; [3,4] in situ-forming microsphere [5] and implants; [6][7][8] micelles, [9] liposomes [10] and microspheres. [11][12][13] The most extensively used technique for producing microspheres is the emulsion/evaporation-based method.…”

Section: Introductionmentioning

confidence: 99%

Size and morphology controlling of PLGA microparticles produced by electro hydrodynamic atomization

Jafari-Nodoushan

Barzin

Mobedi

2015

Polymers for Advanced Techs

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Among the various methods used to produce microparticles, electrospraying is becoming increasingly popular, and it has the advantage of control over the size, shape and morphology of the produced particles. Particle size and morphology are the main factors used to control the rate of microsphere degradation and drug diffusion. The aim of this study was to use some process and solution parameters of the electrospraying such as flow rate, collecting distance, nozzle diameter and polymer molecular weight to control size, shape and morphology of the produced particles. Tests demonstrated that the size of microparticle can be fine-tuned by adjusting the variables of flow rate, collecting distance and nozzle diameter. Other relevant factors that can be as tuning parameters were those of solvent vapor pressure and application of a polymer mix with different molecular weights. Results showed that microparticle size increased under an increased flow rate and needle gauge setting and a decreased electrical field. Results of the tests showed that morphology of the produced microsphere could be adjusted by the aforementioned parameters. For example, by lowering solvent vapor pressure by adding solvent with a high boiling point, the morphology was changed from a textured surface to a smooth one. Molecular weight of the polymer had a significant effect on morphology, whereas polymer with a low molecular weight caused defect in the produced microparticle, and a high molecular weight produced cup-like morphology, but a polymer mix that constituted polymers of high and low Molecular weights improved morphology of the produced particles.

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Section: Introductionmentioning

confidence: 99%

Size and morphology controlling of PLGA microparticles produced by electro hydrodynamic atomization

Jafari-Nodoushan

Barzin

Mobedi

2015

Polymers for Advanced Techs

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“…For drug‐free micelles, 100 mg of P(S‐DMAEMA‐ b ‐HEMA‐ b ‐AAc) was dissolved in 5 mL of dimethylsulfoxide (DMSO) and dialysed against deionized water (200 mL) for 24 h at 4 °C using a cellulose membrane bag (molecular weight cut‐off of 1000 Da, Sigma). The water was replaced hourly for the first 3 h . The obtained micelles, as the supernatant of the plug, were collected using centrifugation at 6000 rpm for 10 min.…”

Section: Methodsmentioning

confidence: 99%

Co‐delivery of methotrexate and doxorubicin via nanocarriers of star‐like poly(DMAEMA‐block‐HEMA‐block‐AAc) terpolymers

Saraei

Sarvari

Massoumi

et al. 2019

Polymer International

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Combined therapy is a promising strategy for clinical cancer treatment with synergistic effects. The purpose of the work reported was to evaluate a smart nanocarrier for co‐delivery of doxorubicin (DOX) and methotrexate (MTX). Since star‐like nanocarriers can load a high dose of drugs with various properties, we developed star polymer nanomicelles based on poly[(2,2‐dimethylaminoethyl methacrylate)‐block‐(2‐hydroxyethyl methacrylate)‐block‐(acrylic acid)] having potential for multi‐drug delivery. The nanomicelles demonstrated high encapsulation efficiency, i.e. 97.1% for DOX and 79.5% for MTX. To this end, the star‐like terpolymers were synthesized via atom transfer radical polymerization with pentaerythritol as an initiator. The micellar properties and dual stimuli‐responsive behaviour of the terpolymers were investigated using transmission electron microscopy, field emission scanning electron microscopy and dynamic light scattering measurements, concluding that this co‐therapy offers a promising approach for cancer treatment. © 2019 Society of Chemical Industry

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“…[45] reported the synthesis of a novel block copolymers based on poly (N-Isopropylacrylamide) (PNIPAAm) block and a degradable poly (L-Lactide) (PLA) one with the purpose to assemble core-shell smart nanoparticles for narcotic antagonists' drug-delivery purpose. Their results revealed that the drug naltrexone was successfully incorporated into the PLA cores, and the drug loading content and release time could be changed by varying the PLA to PNIPAAm ratio.…”

Section: Polyester Copolymersmentioning

confidence: 99%

Emerging Perspectives in the Synthesis of Novel Degradable Biomedical Copolymers

Zhao¹,

Wang²,

Gao³

et al. 2015

Polymer-Plastics Technology and Engineering

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Biodegradable polymer is playing an increasingly significant role in the development of biomedical materials due to its good biocompatibility and biodegradability, and is undoubtedly the focus in the biomedical fields, such as controlled drug delivery, tissue engineering, and regenerative medicine. In this review, some new degradable biomedical copolymers reported over the past 5 years are introduced and discussed in combination with some our research results. The molecular design, chemical structures and related properties of these novel biodegradable copolymers are reported. In summarizing the review, the development, potential applications and future directions of the degradable biomedical copolymers are discussed.

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Smart Poly (N-Isopropylacrylamide)-block-Poly (L-Lactide) Nanoparticles for Prolonged Release of Naltrexone

Cited by 21 publications

References 34 publications

Size and morphology controlling of PLGA microparticles produced by electro hydrodynamic atomization

Size and morphology controlling of PLGA microparticles produced by electro hydrodynamic atomization

Co‐delivery of methotrexate and doxorubicin via nanocarriers of star‐like poly(DMAEMA‐block‐HEMA‐block‐AAc) terpolymers

Emerging Perspectives in the Synthesis of Novel Degradable Biomedical Copolymers

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