Smart polydopamine-based nanoplatforms for biomedical applications: state-of-art and further perspectives

Xu, Hongwei; Zhang, Ying; Zhang, Haotian; Zhang, Yunran; Xu, Qingqing; Lu, Junya; Feng, Shuaipeng; Luo, Xinyi; Wang, Siling; Zhao, Qinfu

doi:10.1016/j.ccr.2023.215153

Cited by 70 publications

(13 citation statements)

References 228 publications

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“…The widespread use of PDA coatings stems primarily from the simplicity, low cost, and adaptability to almost any type of material allowing applications in a variety of contexts. [38][39][40][41][42][43] Implementation of a PDA coating is a one-pot process and requires simply dipping substrates of various kind from plastics of any type to natural fibres or metals in an aqueous slightly alkaline solution of dopamine for an adjustable period of time. The resulting coating is dark and endowed with exceptional adhesion properties.…”

Section: Polydopamine Based Coatings: Mimicking the Mussel Byssus Che...mentioning

confidence: 99%

Multifunctional coatings hinging on the catechol/amine interplay

Alfieri,

Panzella,

Napolitano

2023

Eur J Org Chem

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Design and implementation of functional coatings is a topic of active research in a variety of health‐related applications, most of which require wet adhesion. The powerful wet adhesion of mussel byssus proteins rich in DOPA and lysine residues provided a clue to realize that the combination of a catechol and an amine component has a specific role in the interfacial adhesion. From this natural model, polydopamine (PDA)‐based coatings have been developed that result from the oxidative polymerization of dopamine combining the catechol and amine functionalities in the same molecule. Covalent interactions resulting from Michael‐type addition or Schiff‐base formation of the polymeric products from dopamine oxidation as well as non‐covalent π‐stacking and cation‐π interactions exemplify the diverse mode of catechol/amine interplay that have been identified as responsible of the adhesion and cohesion properties of PDA. In the last decade coatings inspired to the same chemistry but using different starting materials have been explored particularly catechols of natural origin and different amine components, while mechanistic studies with model compounds have allowed to rationalize the structural requirements for adhesion and to expand the potential of these functional coatings.

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Section: Polydopamine Based Coatings: Mimicking the Mussel Byssus Che...mentioning

confidence: 99%

Multifunctional coatings hinging on the catechol/amine interplay

Alfieri,

Panzella,

Napolitano

2023

Eur J Org Chem

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“…Numerous valuable review papers have summarized various aspects of pDA to date. Specifically, they have focused on 1) chemical structures and mechanisms, , and/or 2) its applications in specific fields such as energy, environmental, and biomedical domains. − However, these remain unmet potential for in-depth summaries regarding size and/or shape controls for the tunability of materials properties in the fabrication of nanoscale pDA and related materials, which is the focal point of this Review. Initially, we will explore strategies that employ conventional lithographic approaches to confine the solution-exposed area on the surface and techniques related to transferring patterns or printing of as-prepared pDA NPs and/or coatings.…”

Section: Introductionmentioning

confidence: 99%

Precision Engineering of Polydopamine: Advances in Spatial Fabrication Techniques

Jeong,

Hong

2024

ACS Appl. Polym. Mater.

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Currently available patterning methods, such as lithographic techniques and inkjet printing approaches, heavily rely on material properties and specific applications. This motivates us to explore and develop patterning strategies tailored to the unique characteristics of materials. In this context, we discuss the advancements in site-specific fabrication and patterning of polydopamine (pDA), a versatile coating material widely utilized in biomedical devices. First, we provide a brief Review of the current understanding of the chemical structure of pDA, addressing the ongoing challenges related to its uncontrollability due to its heterogeneous nature. Following this, we examine the control of the shape and morphology during the growth of pDA in the solution phase. Lastly, we comprehensively cover various patterning strategies specifically developed and optimized for the pDA coating. Our goal is to offer insights into the controllable synthesis and fabrication of pDA. We anticipate that this Review will contribute to the advancement of precise and tailored pDA coatings, opening up possibilities for applications in diverse fields, particularly in integrated devices and molecular architecting.

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“…11 In the realm of nanoscience, it has shown promise in modulating the assembly of functional molecules for applications like drug delivery. 12 Additionally, its derivatives have been explored for generating micro/nanopatterns to control surface wettability. 13−15 A decade of research seemed to suggest that polydopamine supports cell adhesion and spreading; 5 however, recent findings by Ding et al indicate that it may actually inhibit cell spreading under certain conditions.…”

Section: Introductionmentioning

confidence: 99%

“…Polydopamine has been employed to modify chemically inert implants such as polytetrafluoroethylene (PTFE), silicone, and titanium alloy, − and has further been utilized to immobilize biomolecules for various functions including anticoagulation, tissue repair, , and anti-inflammation, among others . In the realm of nanoscience, it has shown promise in modulating the assembly of functional molecules for applications like drug delivery . Additionally, its derivatives have been explored for generating micro/nanopatterns to control surface wettability. − A decade of research seemed to suggest that polydopamine supports cell adhesion and spreading; however, recent findings by Ding et al indicate that it may actually inhibit cell spreading under certain conditions .…”

Section: Introductionmentioning

confidence: 99%

Activation of Dopamine Receptor D1 and Downstream Cellular Functions by Polydopamine

Sun,

Wu,

Tian

et al. 2023

ACS Biomater. Sci. Eng.

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Polydopamine is a remarkable molecule that has gained considerable attention for its role in material surface modification, leading to an abundance of research in the biomaterial domain. While its widespread use is well documented, the molecule's potential cellular interactions have been less explored. In particular, dopamine serves as a neurotransmitter and a hormone that interacts with dopamine receptors in cells. Our study sheds light on the previously unexamined interaction between polydopamine and dopamine receptor D1 (DRD1). We discovered that polydopamine, along with its derivatives, such as levodopa and catechol, can activate DRD1�a function previously attributed solely to dopamine. Moreover, we found that polydopamine has the ability to influence cell behavior through the cAMP/ PKA pathway, thereby affecting RhoA activity and stress fiber formation. These observations invite further consideration regarding the biological safety of polydopamine in biomedical contexts and also open avenues for new research directions in designing bioactive functional materials.

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Smart polydopamine-based nanoplatforms for biomedical applications: state-of-art and further perspectives

Cited by 70 publications

References 228 publications

Multifunctional coatings hinging on the catechol/amine interplay

Multifunctional coatings hinging on the catechol/amine interplay

Precision Engineering of Polydopamine: Advances in Spatial Fabrication Techniques

Activation of Dopamine Receptor D1 and Downstream Cellular Functions by Polydopamine

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