This paper presents the practical result of many years of research into human error and failure in the form of accident and incident risk analyses and prevention: ARIADNE, the integrated safety management system. This is based on the three-level model of accident causation, seeing human errors as accident causes and the product of a network of influences which already embody the risks of error-relevant conditions as accident causes. In ARIADNE, the accident event is structurally classified using 2,000 keys. Risk management assigns probabilities and accident as well as measure costs to errors and causes of error, and suggests preventative measures on a cost-risk basis. Risk changes are predicted with the aim of improving safety, saving resources and cutting costs. Benefits are described and the selected results of 10,000 accident analyses are presented.