Smart self-healing coatings on biomedical magnesium alloys: A review

Zhao, Yanbin; Bai, Jing; Xue, Feng; Zeng, Rongchang; Wang, Guomin; Chu, Paul K.; Chu, Chenglin

doi:10.1016/j.smmf.2023.100022

Smart Materials in Manufacturing

2023

DOI: 10.1016/j.smmf.2023.100022

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Smart self-healing coatings on biomedical magnesium alloys: A review

Yanbin Zhao,

Jing Bai,

Feng Xue

et al.

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2024

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Cited by 2 publications

References 156 publications

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An Injectable Magnesium‐Based Cement Stimulated with NIR for Drug‐Controlled Release and Osteogenic Potential

Zhao,

Li,

Wang

et al. 2024

Adv Healthcare Materials

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Magnesium phosphate bone cement (MPC) has gained widespread usage in orthopedic implantation due to its fast‐setting and high initial strength benefits. However, the simultaneous attainment of drug‐controlled release and osteogenic potential in MPC remains a significant challenge. Herein, we proposed a strategy to create a smart injectable cement system using nanocontainers and chondroitin sulfate. It employed nanocontainers containing alendronate‐loaded mesoporous silica nanoparticles, which had been surface‐modified with polypyrrole to control drug release in response to near infrared (NIR) stimulation. The alendronate‐incorporated cement (ACMPC) exhibited improved compressive strength (70.6 ± 5.9 MPa), prolonged setting time (913 s), and exceptional injectability (96.5% of injection rate and 242 s of injection time). It also showed the capability to prevent degradation, thus preserving mechanical properties. Under NIR irradiation, the cement showed good antibacterial properties due to the combined impact of hyperthermia, reactive oxygen species, and alendronate. Furthermore, ACMPC (NIR) group displayed good biocompatibility and osteogenesis capabilities, which also led to an increase in alkaline phosphatase activity, extracellular matrix mineralization, and the upregulation of osteogenic genes. This research has significant implications for developing multifunctional biomaterials and clinical application.This article is protected by copyright. All rights reserved

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An Injectable Magnesium‐Based Cement Stimulated with NIR for Drug‐Controlled Release and Osteogenic Potential

Zhao,

Li,

Wang

et al. 2024

Adv Healthcare Materials

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Superhydrophobic and corrosion-resistant siloxane-modified MgAl–LDHs coatings on magnesium alloy prepared under mild conditions

Zhang,

Zhuo,

et al. 2024

Int J Miner Metall Mater

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Smart self-healing coatings on biomedical magnesium alloys: A review

Cited by 2 publications

References 156 publications

An Injectable Magnesium‐Based Cement Stimulated with NIR for Drug‐Controlled Release and Osteogenic Potential

An Injectable Magnesium‐Based Cement Stimulated with NIR for Drug‐Controlled Release and Osteogenic Potential

Superhydrophobic and corrosion-resistant siloxane-modified MgAl–LDHs coatings on magnesium alloy prepared under mild conditions

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