Smart sensing of Cu²⁺ in living cells by water-soluble and nontoxic Tb³⁺/Eu³⁺-induced aggregates of polysaccharides through fluorescence imaging

Abstract

Nano-sized TIPA is illustrated “off–on” detection of Cu2+ in aqueous and 4T1 cells.

Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan

“…Eu 3+ and Tb 3+ complexes were synthesized according to methods described in publications previously reported by us [ 31 ]. EuCl 3 ·6H 2 O, TbCl 3 ·6H 2 O, TTA, acac, and phen were dissolved in anhydrous ethanol and γ-CD was dissolved in deionized water.…”

“…In situ sensing in complex biological environments requires higher stability, better sensitivity, narrow emission, long fluorescence lifetime, and good biocompatibility [ 29 , 30 ]. Lanthanide ions have narrow emission bands, large stokes shifts, long fluorescence lifetimes, and high quantum yields [ 31 , 32 ]. However, due to the prohibition of the 4f-4f transition, the absorption and emission intensity of the rare earth ion itself is very weak [ 33 ].…”

Nontoxic Tb3+-induced hyaluronic nano-poached egg aggregates for colorimetric and luminescent detection of Fe3+ ions

“…Polymeric materials used as coordinating ligands can provide both dynamic binding and compatibilization with biological and aqueous environments. 38–41…”

“…Polymeric materials used as coordinating ligands can provide both dynamic binding and compatibilization with biological and aqueous environments. [38][39][40][41] Biological polysaccharides as ligands of luminescence sensors can modulate the luminescence properties and biological activity. 42 Hyaluronic acid is a polyanion mucopolysaccharide that consists of a basic unit of glucuronic acid and Nacetylglucosamine.…”

Highly selective fluorescence detection of Cu2+ based on Schiff base functionalized periodic mesoporous organosilicas

“…Although copper (II) is a necessary trace metal for living organisms, excessive intake could lead to serious neurodegenerative disease, [2] therefore the development of simple and sensitive methods for monitoring Cu 2+ is crucial for biological pathological processes and environmental concerns. [3] To date, various molecular optical probes for Cu 2+ ions have been reported, [4,5] however their application in homogeneous phase sensing fields is subject to many restrictions. Due to their better stability and many functions, chemosensors based on nanostructured materials have become a new research direction for detection of metal ions.…”