Smart stimuli-responsive hydrogels for drug delivery in periodontitis treatment

A whole-course-repair system based on ROS/glucose stimuli-responsive EGCG release and tunable mechanical property for efficient treatment of chronic periodontitis in diabetic rats

“…The shape adaptability and injectability of the hydrogel play a very important role in the filling of irregular periodontal pockets. 82 The OPC hydrogel was nimble enough to be remolded into diverse shapes discretionarily, such as star, moon and heart and could be injected into periodontal pockets through the syringe needle without any clogging (Fig. 1(c) and (d)).…”

Cleavage and Noncleavage Chemistry in Reactive Oxygen Species (ROS)-Responsive Materials for Smart Drug Delivery

“…In a recent study, a polymer system called DiSe−PU−DiPy−PEG was synthesized, incorporating Se−Se bonds within its structure. 174 This polymer was then mixed with Mn(CO) 5 Br in DMF to form micelles. Upon exposure to reactive oxygen species (ROS), the diselenide bonds in the polymer underwent oxidation, leading to the formation of seleninic acid and subsequent cleavage of the covalent bond.…”

“…Smart drug delivery systems are commonly categorized based on their response mechanisms, including light-responsive, pH-responsive, heat-responsive, ROS-responsive, and more. Among these, ROS-triggered smart drug delivery has drawn significant attention in recent years. − The concept of reactive oxygen species (ROS) was introduced approximately 80 years ago . Initial research focused on diseases associated with ROS but later expanded to explore their protective functions in physiological processes − and the underlying mechanisms of ROS-mediated cellular signaling. − ROS have been established to play crucial roles in both physiological/biosynthetic processes related to human health and disease pathogenesis. − In terms of human health, ROS are involved in numerous critical processes, including immune system function, − cognitive functions, − muscle physiology, − signal transduction, − thyroid activity, − and aging. − To maintain organismal homeostasis, healthy systems tightly control ROS levels through self-regulating processes. − However, when these processes fail or when health systems are exposed to external threats, excessive ROS production can occur, leading to the development of various diseases, such as cancer, −…”

Preparation of CO2-Responsive Biobased Ternary Composite Microgel and Its Application in Reservoir Gas Channeling Plugging

“…These external stimuli include light, temperature, , pH, , magnetic field, , etc. These materials have high application value and broad application prospects, , such as controllable drug delivery, − intelligent sensors, catalytic control, and so on.…”