Smart textiles in wound care: functionalization of cotton/PET blends with antimicrobial nanocapsules

Quartinello, Felice; Tallian, Claudia; Auer, Julia; Schön, Herta; Vielnascher, Robert; Weinberger, Simone; Wieland, Karin; Weihs, Anna; Herrero-Rollett, Alexandra; Lendl, Bernhard; Teuschl, Andreas; Pellis, Alessandro; Guebitz, Georg M.

doi:10.1039/c9tb01474h

Cited by 26 publications

(11 citation statements)

References 51 publications

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“…Nevertheless, in a recent study antimicrobial cotton wound dressings were developed through coating with pH-responsive human serum albumin/silk fibroin nanocapsules loaded with eugenol. The coated textiles inhibit Staphylococcus aureus and Escherichia coli growth [20]. Also, silver-based materials, due to their recognized antimicrobial activity, have been explored for textiles functionalization.…”

Section: Introductionmentioning

confidence: 99%

Zein impart hydrophobic and antimicrobial properties to cotton textiles

Gonçalves

Torres

Silva

et al. 2020

Reactive and Functional Polymers

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In this work, zein, a by-product of the agricultural industry of corn, was used to impart hydrophobicity and antimicrobial activity to textiles. The cotton textiles were functionalized with zein in two different forms, free or as particles. The optimized coating conditions which rendered the highest hydrophobic character to the textiles were found to be 50 g/L zein in the free form prepared with 70% ethanol. To enhance the antimicrobial activity of the coated textiles, ellagic acid was encapsulated into the zein particles. These presented stable diameters, between 300 and 450 nm, and positive surface charge revealing high encapsulation efficiency. After textiles coating, the controlled release of ellagic acid was tested against different mimetic biologic solutions. The release profile was dependent on the ethanol concentration, on the sweat solution pH and on the external media used during dialysis. The functionalized textiles revealed differentiated antimicrobial activity against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). For E. coli the activity was mainly related with the action of zein while for S. aureus a combined effect between the protein and the ellagic acid was observed. The results herein presented pave the way for the development of new zein-based products for a wide range of applications.

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Section: Introductionmentioning

confidence: 99%

Zein impart hydrophobic and antimicrobial properties to cotton textiles

Gonçalves

Torres

Silva

et al. 2020

Reactive and Functional Polymers

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“…For example, an exciting example of the application of nanocapsules in wound healing therapy was reported by Guartinello and co-workers. The authors developed an antibacterial wound dressing composed of pH-responsive human serum albumin/silk fibroin nanocapsules immobilized onto cotton/polyethylene terephthalate (PET) blends loaded with eugenol [160].…”

Section: Modern Wound Dressing Materials and Nanomaterialsmentioning

confidence: 99%

Composite Membrane Dressings System with Metallic Nanoparticles as an Antibacterial Factor in Wound Healing

et al. 2022

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Wound management is the burning problem of modern medicine, significantly burdening developed countries’ healthcare systems. In recent years, it has become clear that the achievements of nanotechnology have introduced a new quality in wound healing. The application of nanomaterials in wound dressing significantly improves their properties and promotes the healing of injuries. Therefore, this review paper presents the subjectively selected nanomaterials used in wound dressings, including the metallic nanoparticles (NPs), and refers to the aspects of their application as antimicrobial factors. The literature review was supplemented with the results of our team’s research on the elements of multifunctional new-generation dressings containing nanoparticles. The wound healing multiple molecular pathways, mediating cell types, and affecting agents are discussed herein. Moreover, the categorization of wound dressings is presented. Additionally, some materials and membrane constructs applied in wound dressings are described. Finally, bacterial participation in wound healing and the mechanism of the antibacterial function of nanoparticles are considered. Membranes involving NPs as the bacteriostatic factors for improving wound healing of skin and bones, including our experimental findings, are discussed in the paper. In addition, some studies of our team concerning the selected bacterial strains’ interaction with material involving different metallic NPs, such as AuNPs, AgNPs, Fe3O4NPs, and CuNPs, are presented. Furthermore, nanoparticles’ influence on selected eukaryotic cells is mentioned. The ideal, universal wound dressing still has not been obtained; thus, a new generation of products have been developed, represented by the nanocomposite materials with antibacterial, anti-inflammatory properties that can influence the wound-healing process.

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“…However, such techniques are simply inadequate in their capacity to remove the environmental, health, and planetary life risk [ 43 , 45 , 50 ], namely water pollution, harm to flora and fauna, toxicity, and greenhouse gas emissions, just to name a few of such effects. Further, in the chemical depolymerization of poly(ethylene terephthalate) (PET) main constituent synthetic polymer commonly used in the packaging [ 51 ] and textile [ 52 ] industries [ 9 ] or the mechanical recycling of such materials for instance, there is a significant loss to processing costs and resultant byproduct properties, respectively [ 9 ]. As such, plastics’ inability to degrade quickly and safely requires a complete shift in the methods used for their disposal [ 43 , 50 ].…”

Section: Brief Description Of Applications Of Enzymes In Consumer Industriesmentioning

confidence: 99%

Hyaluronic Acid Allows Enzyme Immobilization for Applications in Biomedicine

et al. 2022

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Enzymes are proteins that control the efficiency and effectiveness of biological reactions and systems, as well as of engineered biomimetic processes. This review highlights current applications of a diverse range of enzymes for biofuel production, plastics, and chemical waste management, as well as for detergent, textile, and food production and preservation industries respectively. Challenges regarding the transposition of enzymes from their natural purpose and environment into synthetic practice are discussed. For example, temperature and pH-induced enzyme fragilities, short shelf life, low-cost efficiency, poor user-controllability, and subsequently insufficient catalytic activity were shown to decrease pertinence and profitability in large-scale production considerations. Enzyme immobilization was shown to improve and expand upon enzyme usage within a profit and impact-oriented commercial world and through enzyme-material and interfaces integration. With particular focus on the growing biomedical market, examples of enzyme immobilization within or onto hyaluronic acid (HA)-based complexes are discussed as a definable way to improve upon and/or make possible the next generation of medical undertakings. As a polysaccharide formed in every living organism, HA has proven beneficial in biomedicine for its high biocompatibility and controllable biodegradability, viscoelasticity, and hydrophilicity. Complexes developed with this molecule have been utilized to selectively deliver drugs to a desired location and at a desired rate, improve the efficiency of tissue regeneration, and serve as a viable platform for biologically accepted sensors. In similar realms of enzyme immobilization, HA’s ease in crosslinking allows the molecule to user-controllably enhance the design of a given platform in terms of both chemical and physical characteristics to thus best support successful and sustained enzyme usage. Such examples do not only demonstrate the potential of enzyme-based applications but further, emphasize future market trends and accountability.

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Smart textiles in wound care: functionalization of cotton/PET blends with antimicrobial nanocapsules

Abstract: New antimicrobial pH-responsive wound dressings consisting of immobilized human serum albumin/silk fibroin nanocapsules were developed.

Cited by 26 publications

References 51 publications

Zein impart hydrophobic and antimicrobial properties to cotton textiles

Zein impart hydrophobic and antimicrobial properties to cotton textiles

Composite Membrane Dressings System with Metallic Nanoparticles as an Antibacterial Factor in Wound Healing

Hyaluronic Acid Allows Enzyme Immobilization for Applications in Biomedicine

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