Smart Titanium Coating Composed of Antibiotic Conjugated Peptides as an Infection‐Responsive Antibacterial Agent

Zhang, Yunfei; Hu, Kuan; Xing, Xuan; Zhang, Jingshuang; Zhang, Ming‐Rong; Ma, Xuexiao; Shi, Rui; Zhang, Liqun

doi:10.1002/mabi.202000194

Cited by 20 publications

(19 citation statements)

References 49 publications

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“…As shown in Figure 7 [56,57], the antibacterial modification of orthopedic implants can also be divided into bacterial repelling and killing, in addition to other specific properties. Researchers have designed various surfaces for orthopedic implants to inhibit the formation of biofilms [58][59][60], such as anti-adhesion surfaces, responsive biocides-containing coating.…”

Section: Orthopedic Implantsmentioning

confidence: 99%

Antibacterial surfaces: Strategies and applications

Yang

Hou

Tian

et al. 2022

Sci. China Technol. Sci.

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Antibacterial surfaces are surfaces that can resist bacteria, relying on the nature of the material itself. It is significant for safe food and water, human health, and industrial equipment. Biofilm is the main form of bacterial contamination on the material surface. Preventing the formation of biofilm is an efficient way to develop antibacterial surfaces. The strategy for constructing the antibacterial surface is divided into bacteria repelling and bacteria killing based on the formation of the biofilm. Material surface wettability, adhesion, and steric hindrance determine bacteria repelling performance. Bacteria should be killed by surface chemistry or physical structures when they are attached to a material surface irreversibly. Killing approaches are usually in the light of the cell membrane of bacteria. This review summarizes the fabrication methods and applications of antibacterial surfaces from the view of the treatment of the material surfaces. We also present several crucial points for developing long-term stability, no drug resistance, broad-spectrum, and even programable antibacterial surfaces.

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Section: Orthopedic Implantsmentioning

confidence: 99%

Antibacterial surfaces: Strategies and applications

Yang

Hou

Tian

et al. 2022

Sci. China Technol. Sci.

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“…The third study also describes a coating with an infection-triggered release [ 24 ]. Vancomycin was conjugated with the SRP protein, which is cleavable by the S. aureus protein SplB then releasing vancomycin.…”

Section: Resultsmentioning

confidence: 99%

Infections @ Trauma/Orthopedic Implants: Recent Advances on Materials, Methods, and Microbes—A Mini-Review

Wildemann

2021

Materials

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Implants and materials are indispensable in trauma and orthopedic surgery. The continuous improvements of implant design have resulted in an optimized mechanical function that supports tissue healing and restoration of function. One of the still unsolved problems with using implants and materials is infection. Trauma and material implantation change the local inflammatory situation and enable bacterial survival and material colonization. The main pathogen in orthopedic infections is Staphylococcus aureus. The research efforts to optimize antimicrobial surfaces and to develop new anti-infective strategies are enormous. This mini-review focuses on the publications from 2021 with the keywords S. aureus AND (surface modification OR drug delivery) AND (orthopedics OR trauma) AND (implants OR nails OR devices). The PubMed search yielded 16 original publications and two reviews. The original papers reported the development and testing of anti-infective surfaces and materials: five studies described an implant surface modification, three developed an implant coating for local antibiotic release, the combination of both is reported in three papers, while five publications are on antibacterial materials but not metallic implants. One review is a systematic review on the prevention of stainless-steel implant-associated infections, the other addressed the possibilities of mixed oxide nanotubes. The complexity of the approaches differs and six of them showed efficacy in animal studies.

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“…One of the reasons for using this drug is its low cost in a powder form. [118,119] The main use of Van is for severe infections caused by gram-positive bacteria. The mode of action of Van as antibiotic is to kill bacteria by disrupting its cells' wall biosynthesis.…”

Section: Drugs In Wound Healingmentioning

confidence: 99%

An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

Mirhaj

Labbaf

Tavakoli

et al. 2022

Macromolecular Bioscience

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A wound can be surgical cuts from an operation or due to accident and trauma. The infected wound, as a result of bacteria growth within the damaged skin, interrupts the natural wound healing process and significantly impacts the quality of life. Wound dressing is an important segment of the skincare industry with its economic burden estimated at $ 20.4 billion (in 2021) in the global market. The results of recent clinical trials suggest that the use of modern dressings can be the easiest, most accessible, and most cost‐effective way to treat chronic wounds and, hence, holds significant promise. With the sheer number of dressings in the market, the selection of correct dressing is confusing for clinicians and healthcare workers. The aim of this research is to review widely used types of antibacterial wound dressings, as well as emerging products, for their efficiency and mode of action. In this review, introducing antibiotics and antibacterial nanoparticles as two important and clinically widely used categories of antibacterial agents is focused. The perspectives and challenges for paving the way for future research in this field are also discussed.

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Smart Titanium Coating Composed of Antibiotic Conjugated Peptides as an Infection‐Responsive Antibacterial Agent

Cited by 20 publications

References 49 publications

Antibacterial surfaces: Strategies and applications

Antibacterial surfaces: Strategies and applications

Infections @ Trauma/Orthopedic Implants: Recent Advances on Materials, Methods, and Microbes—A Mini-Review

An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

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