Smart transformation of bowl shape chitosan nanomotors to disc shape in simulated biological media and consequent controlled velocity

Karimi, Mohammad Reza; Khoee, Sepideh; Shaghaghi, Behrad

doi:10.1016/j.jddst.2022.104096

Cited by 7 publications

(8 citation statements)

References 32 publications

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“…Furthermore, comparing the drug/copolymer-coated nanomotor group to only the drug- conjugated copolymer group revealed marginally lower toxicity in the latter. This difference may be due to the abundance of H 2 O 2 near cancerous cells, 37 which acts as fuel for the nanomotor, facilitating the motion and proximity of drugcontaining nanomotors toward the cells and enhancing their cytotoxicity.…”

Section: Synthesis Of Au−pt Nanomotors Coated With Drug-conjugated Co...mentioning

confidence: 99%

Copolymer-Coated Au–Pt Nanomotors for Delivery of Disulfiram Prodrug

Kamankesh,

Kargari Aghmiouni,

Khoee

2024

ACS Appl. Nano Mater.

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Researchers have been exploring the use of nanomotors powered by hydrogen peroxide for cancer treatment through targeted drug delivery. Asymmetric bimetallic nanorods made of platinum and gold have been found to navigate through the H 2 O 2 environment quickly and effectively, making them a promising option for the delivery of drugs to specific areas. We developed a delivery system for the hydroxyethyl disulfiram (DSF−OH) anticancer prodrug using a bimetallic Au/Pt nanomotor that moves toward its target in the presence of hydrogen peroxide. A copolymer consisting of poly(polyethylene glycol methyl ether methacrylate)-co-poly acrylic acid was used to conjugate the drug. The conjugate was then attached to the nanomotor's gold (Au) component using the sulfur moieties present in the DSF. The 1 H NMR, 13 C NMR, TGA, and FT-IR analyses confirmed the successful synthesis of the copolymer, whereas the SEM, EDX, XRD, and DLS analyses confirmed the production of the bimetallic nanomotor. Hydroxyethyl disulfiram (DSF−OH) was found to have different complex formation capabilities and time-dependent stabilities in comparison to disulfiram (DSF). It is suitable for prolonged drug release evaluations. UV−vis analysis evaluations showed around 34% of the released DSF− OH from the nanomotors. Particle tracking revealed a correlation between H 2 O 2 concentration and particle motion, indicating that higher H 2 O 2 concentration results in higher velocity and mean-square displacements (MSDs). MTT assays further validated superior selectivity and toxicity of drug-containing nanomotors toward MCF-7 breast cancer cells compared to L929 fibroblast cells. These findings have implications for drug delivery systems and provide insight into designing more efficient systems.

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Section: Synthesis Of Au−pt Nanomotors Coated With Drug-conjugated Co...mentioning

confidence: 99%

Copolymer-Coated Au–Pt Nanomotors for Delivery of Disulfiram Prodrug

Kamankesh,

Kargari Aghmiouni,

Khoee

2024

ACS Appl. Nano Mater.

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“…Karimi ve ekibi H2O2 yakıtı ile katalitik olarak hareket sağlayan disk şeklinde nanomotorlar sentezlemiş ve anti-kanser ilacı olan quercetin kullanarak tümör bölgesine müdahale etmişlerdir. Çalışmada sentezlenen platin bazlı motor, H2O2'i su ve oksijene ayrıştırma sureti ile kabarcıklar üreterek hareket eder [58]. Xing ve ekibinin tümör penetrasyonu için H2O2 ve NIR çift tahrikli karbon/mangan nanomotorlar çalışması ise çift tahrikli motor hareketine örnek olarak verilebilir [59].…”

Section: Biyohibrit Nano/mikromotorlarunclassified

Kanser Teşhis ve Tedavisinde Nano/mikromotor Teknolojisi

TÜRKER

Bulbul

Öksüz

et al. 2023

Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım Ve Teknoloji

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Nano/mikromotorlar, enerjiyi harekete dönüştürme kabiliyetine sahip nano veya mikro boyutta makinalardır. Bunlar; kimyasal yakıt ve harici etkenler neticesinde enerjiyi harekete dönüştürme prensibi ile çalışırlar. Bu harici etkenler; manyetik alan, elektrik alan, ultrason ve ışık gibi etkenler olabilir. Farklı tahrik mekanizmalarına sahip nano/mikromotorlar kanser ve bulaşıcı hastalıkların teşhis ve tedavisinde önemli rol oynarlar. Özellikle kanser tedavilerinde en çok tercih edilen yöntem olan kemoterapi ve radyoterapi gibi yöntemlerin insan sağlığı üzerindeki olumsuz etkileri, araştırmacıları nano/mikromotor çalışmalarına yönlendirmiştir. Nano/mikromotorlar; kanserleşmiş hücrenin erken teşhisini mümkün kılması ve geleneksel kanser tedavilerindeki yan etkilerin en aza indirilmesi gibi avantajlara sahiptir. Bu derlemede nano/miktomotorların sınıflandırılması ve sentez yöntemleri ele alınmakla birlikte, nano/mikromotorların kanser teşhis ve tedavisinde kullanımı açıklanmıştır.

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“…Among them, bowl-shaped nanoparticles (BNPs) have drawn wide attention due to their anisotropic structure and a large opening on the surface, promoting their applications in smart carrier especially for large-sized cargoes, 9 cancer therapy, 10 water remediation, 11 and nanomotors. 12 The recent advances of polymeric BNPs have been summarized in our recent review article. 13 There are several methods to prepare BNPs such as swelling and freeze-drying of polymeric beads, 14 emulsion polymerization, 15 self-assembly of amphiphilic molecules, 16 and template-assisted method.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Polymer self-assembly has been widely used to prepare a large variety of nanomaterials, including micelles, vesicles, cylinders, and lamellaes, showing significant potentials in drug delivery, antimicrobial, anticancer and catalysis, etc. Among them, bowl-shaped nanoparticles (BNPs) have drawn wide attention due to their anisotropic structure and a large opening on the surface, promoting their applications in smart carrier especially for large-sized cargoes, cancer therapy, water remediation, and nanomotors . The recent advances of polymeric BNPs have been summarized in our recent review article .…”

Section: Introductionmentioning

confidence: 99%

Manipulation of Bowl-Shaped Nanoparticles Self-Assembled from a Bipyridine Pendant Containing Homopolymer

Fan,

Sun

2024

Langmuir

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The morphological control and transformation of soft nanomaterials are critical for their physical and chemical properties, which can be achieved by dynamically regulating the hydrophilicity of amphiphilic polymers during self-assembly. Herein, an amphiphilic homopolymer poly(N-(2,2′-bipyridine)-4acrylamide) (PBPyAA) with bipyridine pendants is synthesized, and the effect of various parameters including initial concentration, temperature, pH, and metal ion coordination on the self-assembly behavior and morphology of the assemblies is investigated. Upon changing the initial concentration of PBPyAA, bowl-shaped nanoparticles (BNPs) with precisely controlled diameter, opening size, and thickness are obtained. With the decrease of pH of the solution, the negatively charged surface of BNPs transforms to a positively charged state. Furthermore, the addition of divalent metal ions (Co 2+ , Mn 2+ , and Zn 2+ ) induces the transformation of BNPs to vesicles and giant vesicles. The effect of the above factors on the morphology of the assemblies is essential to change the hydrophilicity of PBPyAA dynamically, leading to variation of the local viscosity during self-assembly. Overall, manipulation of the structural parameters of BNPs and transformation of BNPs to vesicles are achieved, providing fresh insights for the precise control of the morphologies of soft nanomaterials.

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Smart transformation of bowl shape chitosan nanomotors to disc shape in simulated biological media and consequent controlled velocity

Cited by 7 publications

References 32 publications

Copolymer-Coated Au–Pt Nanomotors for Delivery of Disulfiram Prodrug

Copolymer-Coated Au–Pt Nanomotors for Delivery of Disulfiram Prodrug

Kanser Teşhis ve Tedavisinde Nano/mikromotor Teknolojisi

Manipulation of Bowl-Shaped Nanoparticles Self-Assembled from a Bipyridine Pendant Containing Homopolymer

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