Smart UV spectrophotometric methods based on simple mathematical filtration for the simultaneous determination of celecoxib and ramipril in their pharmaceutical mixtures with amlodipine: A comparative statistical study

Attala, Khaled; Elsonbaty, Ahmed

doi:10.1016/j.saa.2020.118853

Cited by 28 publications

(11 citation statements)

References 39 publications

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“…[5,6] Pharmaceutical analysis research is considered the best sector that can both provide greener surrogates and utilize them at the same time to achieve greener research methodologies. [7][8][9][10][11] Analytical method development is a multistep process involving several trial and error cycles bearing within a huge environmental burden due to the variety of the utilized solvents and reagents. [12,13] Early efforts to turn the method development phase greener were by excluding the use of solvents and reagents of the highest ecological impact.…”

Section: Introductionmentioning

confidence: 99%

Greenness‐by‐design approach for developing novel UV spectrophotometric methodologies resolving a quaternary overlapping mixture

Abdelshakour

Eissa

Attala

et al. 2023

Archiv der Pharmazie

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Greenness-by-design (GbD) is an approach that integrates green chemistry principles into the method development stage of analytical processes, aiming to reduce their environmental impact. In this work, we applied GbD to a novel univariate double divisor corrected amplitude (DDCA) method that can resolve a quaternary pharmaceutical mixture in a fixed-dose polypill product. We also used a genetic algorithm as a chemometric modeling technique to select the informative variables for the analysis of the overlapping mixture. This resulted in more accurate and efficient predictive models. We used a computational approach to study the effect of solvents on the spectral resolution of the mixture and to minimize the spectral interferences caused by the solvent, thus achieving spectral resolution with minimal analytical effort and ecological footprint. The validated methods showed wide linear concentration ranges for the four components (1-30 µg/mL for losartan, 2.5-30 µg/mL for atorvastatin and aspirin, and 2.5-35 µg/mL for atenolol) and achieved high scores on the hexagon and spider charts, demonstrating their eco-friendliness.

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Section: Introductionmentioning

confidence: 99%

Greenness‐by‐design approach for developing novel UV spectrophotometric methodologies resolving a quaternary overlapping mixture

Abdelshakour

Eissa

Attala

et al. 2023

Archiv der Pharmazie

Self Cite

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“…Ultraviolet-visible (UV-vis) spectroscopy is considered to be an effective technique for water quality detection, benefiting from its fast, inexpensive, non-invasive, and highly sensitive characteristics [7][8][9][10]. Compared with chemical methods, UV-Vis spectroscopy is an indirect method that relies on the established regression model and can avoid the tedious oxidative digestion procedure [11].…”

Section: Introductionmentioning

confidence: 99%

A fast online chemical oxygen demand method based on time-varying spectrum

Geng¹,

Yang²,

Li³

2023

Ninth Symposium on Novel Photoelectronic Detection Technology and Applications

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“…A study of the relevant literature revealed a plethora of analytical methods for the evaluation of CXB and TMD both on their own and in combination dosage forms with other medications. These methodologies include UV Spectrophotometry, [10][11][12][13][14][15][16] HPLC, 15,[17][18][19][20][21][22][23][24][25][26][27][28] HPTLC, 18,[29][30][31][32] and LC-MS/MS. 33 On the other hand, the simultaneous measurement of CXB and TMD in the binary combination has not been reported by any analytical methods until this point.…”

Section: Introductionmentioning

confidence: 99%

Different Innovative UV-spectroscopic Approaches for Simultaneous Assessment of Celecoxib and Tramadol Hydrochloride in Binary Mixture

Sen,

Darji,

Sen

et al. 2023

Ind. J. Pharm. Edu. Res.

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Background and Aim: Tablets containing celecoxib and tramadol hydrochloride that are sold under the brand name Seglentis® have given approval by the "Food and Drug Administration" (FDA) for the treatment of adults suffering from acute pain. Simultaneous assessment of celecoxib and tramadol hydrochloride in synthetic mixture was performed by five new UV-spectrophotometric approaches. Materials and Methods: The quantification of proposed medication was performed using the simultaneous equation approach by measuring absorbance at 217.2 and 272.4 nm. The second approach, known as the dual wavelength method, relies on computing the absorbance difference at two different wavelengths where the other drug has same absorbance. The first derivative zero crossing approach relied on the conversion of UV-spectra into first derivative spectra and subsequently measuring the amplitude at 272.4 and 229.6 nm for celecoxib and tramadol hydrochloride, respectively. The ratio difference approach was used to measure the variation in the amplitudes of ratio spectra, and the regression equation was employed to determine the amounts of pharmaceuticals. In first derivative ratio spectra approach, the UV-spectra were transformed into their ratio spectra and first derivatives, and the first-derivative signal was gauged at 236.4 and 229.8 nm for celecoxib and tramadol hydrochloride, sequentially. Results and Discussion: All the parameters were evaluated during validation of the new methods in accordance with ICH guidelines. For both medicines, a linear response was observed in all five methods over the concentration series of 1-18 µg/mL. Method validation parameters were found to be within the permitted limits set forth by the ICH. Conclusion: Assay results were compared using Repeated Measures ANOVA, IBM SPSS, version 20.0. The findings of the statistical analysis demonstrated that none of the projected methods differed significantly from others. Thus, the anticipated approaches have the potential to be productively utilized for the simultaneous evaluation of celecoxib and tramadol hydrochloride in a combination mixture.

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Smart UV spectrophotometric methods based on simple mathematical filtration for the simultaneous determination of celecoxib and ramipril in their pharmaceutical mixtures with amlodipine: A comparative statistical study

Cited by 28 publications

References 39 publications

Greenness‐by‐design approach for developing novel UV spectrophotometric methodologies resolving a quaternary overlapping mixture

Greenness‐by‐design approach for developing novel UV spectrophotometric methodologies resolving a quaternary overlapping mixture

A fast online chemical oxygen demand method based on time-varying spectrum

Different Innovative UV-spectroscopic Approaches for Simultaneous Assessment of Celecoxib and Tramadol Hydrochloride in Binary Mixture

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