smartPearls® for dermal bioavailability enhancement – Long-term stabilization of suspensions by viscoelasticity

Hespeler, David; Knoth, Daniel; Keck, Cornelia M.; Müller, Rainer H.; Pyo, Sung Min

doi:10.1016/j.ijpharm.2019.03.016

Cited by 10 publications

(2 citation statements)

References 13 publications

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“…A number of novel dosage forms have been recently proposed to overcome this limitation of CUR efficacy in the improvement of psoriasis. Interesting outcomes in topical administration have been reported when CUR was used in the form of nano-emulgel [37], bi-phasic emulgel with tea tree oil [38], microemulsions [27], peptide-modified liposomes loaded with curcumin [39], nanostructured lipid carriers [40], nano-sponges [41], invasosomes [42], and smartPearls ® technology [43,44]. Some innovative oral forms of CUR have been also investigated.…”

Section: Curcumin and Skin Diseases 21 Psoriasismentioning

confidence: 99%

Potential of Curcumin in the Management of Skin Diseases

Kasprzak-Drozd,

Niziński,

Hawrył

et al. 2024

IJMS

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Curcumin is a polyphenolic molecule derived from the rhizoma of Curcuma longa L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal for preventing and treating skin inflammation, premature skin ageing, psoriasis, and acne. Additionally, it exhibits antiviral, antimutagenic, and antifungal effects. Curcumin provides protection against skin damage caused by prolonged exposure to UVB radiation. It reduces wound healing times and improves collagen deposition. Moreover, it increases fibroblast and vascular density in wounds. This review summarizes the available information on the therapeutic effect of curcumin in treating skin diseases. The results suggest that curcumin may be an inexpensive, well-tolerated, and effective agent for treating skin diseases. However, larger clinical trials are needed to confirm these observations due to limitations in its in vivo use, such as low bioavailability after oral administration and metabolism.

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Section: Curcumin and Skin Diseases 21 Psoriasismentioning

confidence: 99%

Potential of Curcumin in the Management of Skin Diseases

Kasprzak-Drozd,

Niziński,

Hawrył

et al. 2024

IJMS

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“…The physical stability of sea buckthorn juices was determined using a LUMiSizer (L.U.M. 290 GmbH, Berlin, Germany) based on the established principle that uses centrifugal sedimentation to accelerate the occurrence of instability phenomena such as sedimentation, flocculation and creaming [27]. The measurements were carried out under the following conditions: the rotation speed was 4000 rpm, the acquisition time was 5400 s at 25 °C and the time intervals were 20 s.…”

Section: Physical Stabilitymentioning

confidence: 99%

Effects of Emulsifiers on Physicochemical Properties and Carotenoids Bioaccessibility of Sea Buckthorn Juice

Abliz,

Huang,

Rouzi

et al. 2024

Foods

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The need to improve the physicochemical properties of sea buckthorn juice and the bioavailability of carotenoids is a major challenge for the field. The effects of different natural emulsifiers, such as medium-chain triglycerides (MCTs), tea saponins (TSs) and rhamnolipids (Rha), on the physical and chemical indexes of sea buckthorn juice were studied. The particle size of sea buckthorn juice and the carotenoids content were used as indicators for evaluation. The effects of different addition levels of MCT, Rha and TS on the bioavailability of carotenoids in sea buckthorn juice were investigated by simulating human in vitro digestion tests. The results showed that those emulsifiers, MCT, Rha and TS, can significantly reduce the particle size and particle size distribution of sea buckthorn juice, improve the color, increase the soluble solids content, turbidity and physical stability and protect the carotenoids from degradation. When the addition amount of Rha was 1.5%, the total carotenoids content (TCC) of sea buckthorn juice increased by 45.20%; when the addition amount of TS was 1.5%, the total carotenoids content (TCC) of sea buckthorn juice increased by 37.95%. Furthermore, the bioaccessibility of carotenoids was increased from 36.90 ± 2.57% to 54.23 ± 4.17% and 61.51 ± 4.65% through in vitro digestion by Rha and TS addition, respectively. However, the total carotenoids content (TCC) of sea buckthorn juice and bioaccessibility were not significantly different with the addition of MCT. In conclusion, the findings of this study demonstrate the potential of natural emulsifiers, such as MCT, Rha and TS, to significantly enhance the physicochemical properties and bioavailability of carotenoids in sea buckthorn juice, offering promising opportunities for the development of functional beverages with improved nutritional benefits.

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Analytical photo-centrifuge-based prediction of shelf-life and droplet packing behaviour of nanoemulsions upon removal of excess micelles

Kadiya

Ghosh

2021

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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smartPearls® for dermal bioavailability enhancement – Long-term stabilization of suspensions by viscoelasticity

Cited by 10 publications

References 13 publications

Potential of Curcumin in the Management of Skin Diseases

Potential of Curcumin in the Management of Skin Diseases

Effects of Emulsifiers on Physicochemical Properties and Carotenoids Bioaccessibility of Sea Buckthorn Juice

Analytical photo-centrifuge-based prediction of shelf-life and droplet packing behaviour of nanoemulsions upon removal of excess micelles

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