Since the early 2000s, information systems have been widely employed across hospitals in China, changing the way in which processes are managed, improving customer satisfaction and strengthening business competence. Intelligent Guidance Systems for Patients (IGSP), which resemble humanoid characteristics using Artificial Intelligence (AI), assist patients in wayfinding, obtaining medical guidance, consultations, and other medical services, and can improve user experiences before, during and after hospital visits. However, despite their widespread adoption, usability studies on such systems are scarce. To date, there is no practical or standardized measurement for system usability, leading to difficult inspection, maintenance and servicing processes. This study aims to determine the usability deficiency of IGSP and understand how various factors influence user satisfaction during their use. We employ the requirements set out in the ISO9241-11:2018 standard, using two inspection methods with 3 experts and 346 valid end-users. First, a Heuristic evaluation method was employed to detect usability problems and to demonstrate violations of Nielsen's 10 heuristic principles. Second, a System Usability Scale (SUS) was applied to evaluate participants' satisfaction towards IGSP.Finally, analysis of variance tests and a multiple linear regression analysis was performed to establish correlations between user satisfaction and characteristics.