Smartphone-based differential pulse amperometry system for real-time monitoring of levodopa with carbon nanotubes and gold nanoparticles modified screen-printing electrodes

Ji, Daizong; Xu, Ning; Liu, Zixiang; Shi, Zhouyuanjing; Low, Sze Shin; Liu, Jingjing; Cheng, Chen; Zhu, Jingwen; Zhang, Tingkai; Xu, Haoxuan; Yu, Xiongjie; Liu, Qingjun

doi:10.1016/j.bios.2018.09.082

Cited by 76 publications

(35 citation statements)

References 55 publications

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“…These types of applications are extremely different in terms of the variety of chemical structures to be analyzed (samples) and the functionality of the smartphone application used to process the samples . Imaging techniques are not popular in this category, as the adapter consists of special electronics that are designed specifically to target a unique chemical compound . Using a smartphone proved to be cost effective (see Figure 12), and extremely accurate results were reported when comparing the performance of the smartphone‐based adapters to those of laboratory equipment and devices with a low CV%, a high regression coefficient, lower costs, and a low LOD (see Figures to ) .…”

Section: Resultsmentioning

confidence: 99%

“…[161][162][163][164][165][166][167] Imaging techniques are not popular in this category, as the adapter consists of special electronics that are designed specifically to target a unique chemical compound. [168][169][170][171][172][173][174] Using a smartphone proved to be cost effective (see Figure 12), and extremely accurate results were reported when comparing the performance of the smartphone-based adapters to those of laboratory equipment and devices with a low CV%, a high regression coefficient, lower costs, and a low LOD (see Figures 10 to 13). [175][176][177][178][179][180][181][182][183][184][185][186][187][188][189][190][191][192] Zhao et al, 193 as shown in Figure 8A, developed a fluorescent smartphone-based label-free sensor to detect Fe (III) by employing the quenching effect.…”

Section: Electrochemical Applicationsmentioning

confidence: 96%

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A review of smartphone point‐of‐care adapter design

Alawsi

Al-Bawi

2019

Engineering Reports

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In this review, we explore the potential of smartphone‐based applications based on their unique ability to support portable, easy‐to‐use, precise, and efficient functions, which, in turn, makes lab‐on‐hardware a trending area of novel research. Smartphones can assist surgeons, physicians, biologists, chemists, ophthalmologists, and laboratory technicians in maintaining an easy‐to‐use, cost‐effective, and integrated environment for treatment, diagnosis, and point‐of‐care (POC) applications. These POC applications can improve patients' quality of life, offering patients a precise diagnosis and the correct treatment. This is a noble goal that aims to reduce costs and to increase the accuracy of sample testing, treatment, and diagnosis. Recent innovations have made major advances in smartphone adapters, providing portability, robustness, self‐powered devices, small‐sized adapters, and ease of usage. Lab‐on‐hardware is a progressing field, and smartphone imaging applications are increasingly expanding, resulting in POC applications with the latest and most advanced image analysis, enhancement, recognition, and other image processing techniques. The most recent studies in the field are explored to provide a solid background to interested researchers against which they can choose of application and/or adapter design they aim to develop, with a discussion of the methods reviewed here.

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Section: Resultsmentioning

confidence: 99%

Section: Electrochemical Applicationsmentioning

confidence: 96%

A review of smartphone point‐of‐care adapter design

Alawsi

Al-Bawi

2019

Engineering Reports

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“…In this system, AuNPs were used to modify the electrode to improve the electrical conductivity and electrocatalytic performance so as to increase the sensitivity of the sensor. This sensor could detect levodopa at concentration as low as 0.5 µM in human serum (Ji et al, 2019). In another study, AuNPs were used to detect hepatitis B surface antigen.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Application of Zero-Dimensional Nanomaterials in Biosensing

et al. 2020

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Zero-dimensional (0D) nanomaterials, including graphene quantum dots (GQDs), carbon quantum dots (CQDs), fullerenes, inorganic quantum dots (QDs), magnetic nanoparticles (MNPs), noble metal nanoparticles, upconversion nanoparticles (UCNPs) and polymer dots (Pdots), have attracted extensive research interest in the field of biosensing in recent years. Benefiting from the ultra-small size, quantum confinement effect, excellent physical and chemical properties and good biocompatibility, 0D nanomaterials have shown great potential in ion detection, biomolecular recognition, disease diagnosis and pathogen detection. Here we first introduce the structures and properties of different 0D nanomaterials. On this basis, recent progress and application examples of 0D nanomaterials in the field of biosensing are discussed. In the last part, we summarize the research status of 0D nanomaterials in the field of biosensing and anticipate the development prospects and future challenges in this field.

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“…After that, the layer-by-layer self-assembled sandwich-structured screen-printed electrodes ( Figure 1a) were established by subsequently adding 10 µL gold nanoparticles (AuNPs) to the working electrode with linkage of Au-S bonds between MoS 2 SAM and AuNPs, and the second self-assembled monolayer of AuNPs was formed. The preparation of the latter layer of gold nanoparticles (AuNPs) has been described in the previous papers [14,38]. In short, 100 µL chloroauric acid (HAuCl 4 , 1%) was diluted 10 times with deionized water and heated to 80 • dispersion (MoS2, 1 mg/mL) was dropped evenly onto the working electrode surface and air-dried for about 1 h to form stable Au-S covalent bonds, and an effective self-assembled monolayer (SAM) of MoS2 was created.…”

Section: Fabrication Of the Sandwich-structured Immunosensor For Cortmentioning

confidence: 99%

“…The merits of smartphones brought new possibilities for biomedical and biosensor research. Recently, many studies on smartphone-controlled platforms at the point of care (POC) have been published and several electrochemical methods have been combined with smartphone for quantitative electrochemical detections, such as chronoamperometry (CA), cyclic voltammetry (CV), differential pulse voltammetry (DPV) [13,14] and electrochemical impedance spectroscopy (EIS) [14][15][16][17]. Among them, DPV is capable of detection of low-level concentrations of analytes.…”

Section: Introductionmentioning

confidence: 99%

Salivary Cortisol Determination on Smartphone-Based Differential Pulse Voltammetry System

Liu

Men

et al. 2020

Sensors

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Cortisol is commonly used as a significant biomarker of psychological or physical stress. With the accelerated pace of life, non-invasive cortisol detection at the point of care (POC) is in high demand for personal health monitoring. In this paper, an ultrasensitive immunosensor using gold nanoparticles/molybdenum disulfide/gold nanoparticles (AuNPs/MoS2/AuNPs) as transducer was explored for non-invasive salivary cortisol monitoring at POC with the miniaturized differential pulse voltammetry (DPV) system based on a smartphone. Covalent binding of cortisol antibody (CORT-Ab) onto the AuNPs/MoS2/AuNPs transducer was achieved through the self-assembled monolayer of specially designed polyethylene glycol (PEG, SH-PEG-COOH). Non-specific binding was avoided by passivating the surface with ethanolamine. The miniaturized portable DPV system was utilized for human salivary cortisol detection. A series current response of different cortisol concentrations decreased and exhibited a linear range of 0.5–200 nM, the detection limit of 0.11 nM, and high sensitivity of 30 μA M−1 with a regression coefficient of 0.9947. Cortisol was also distinguished successfully from the other substances in saliva. The recovery ratio of spiked human salivary cortisol and the variation of salivary cortisol level during one day indicated the practicability of the immunosensor based on the portable system. The results demonstrated the excellent performance of the smartphone-based immunosensor system and its great potential application for non-invasive human salivary cortisol detection at POC.

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Smartphone-based differential pulse amperometry system for real-time monitoring of levodopa with carbon nanotubes and gold nanoparticles modified screen-printing electrodes

Cited by 76 publications

References 55 publications

A review of smartphone point‐of‐care adapter design

A review of smartphone point‐of‐care adapter design

Application of Zero-Dimensional Nanomaterials in Biosensing

Salivary Cortisol Determination on Smartphone-Based Differential Pulse Voltammetry System

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