Smartphone-based paper strip assay for putrescine and spermidine detection using hybrid organic–inorganic perovskite with Eu<sup>3+</sup> complex

Truong, Thi Thuy; Huy, Bui The; Huong, Le Thi Cam; Truong, Hai Bang; Lee, Yong-Ill

doi:10.1039/d4an00219a

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2024

DOI: 10.1039/d4an00219a

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Smartphone-based paper strip assay for putrescine and spermidine detection using hybrid organic–inorganic perovskite with Eu³⁺ complex

Thi Thuy Truong,

Bui The Huy,

Le Thi Cam Huong

et al.

Abstract: A new method utilizing fluorescent ratiometry is proposed for detecting putrescine and spermidine. The method involves the use of a fluorescent probe comprising a 2D halide perovskite synthesized from octadecylamine-iodine...

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Circulating Metabolic Markers Identify Patients at Risk for Tumor Recurrence

Montcusí,

Madrid-Gambin,

Marin

et al. 2024

Annals of Surgery

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Objective: To investigate the spermidine pathway capability to predict patients at risk for tumor recurrence following colorectal cancer (CRC) surgery. Summary Background Data: Recurrence rates after CRC surgery remain about 20%, despite an optimal technique and adjuvant therapy when necessary. Identification of risk biomarkers of recurrence is an unmet need. The spermidine pathway is indispensable for cell proliferation and differentiation, and is suggested to accelerate tumor spread. Methods: Prospective cohort study of patients undergoing CRC surgery from 2015 to 2018. Plasma samples were collected before surgery and on postoperative day 4, and the spermidine pathway was assessed through mass spectrometry. Oncological outcomes were registered. Results: 146 patients were included and 24 (16.4%) developed tumor recurrence. Higher levels of preoperative spermidine pathway components (spermidine, spermine, spermidine synthase enzyme, and spermine/arginine balance) were positively associated with recurrence. Surgery promoted a decrease in these pathway elements. The greater the decline was, the lower the risk of recurrence. Preoperative spermidine over the cut-off 0.198 µM displayed a 4.69-fold higher risk of recurrence. The spermine synthase enzyme behaved in the opposite direction. Conclusions: The spermidine pathway is associated with tumor recurrence following CRC surgery and, after confirmation in larger cohorts, could be translated as a risk biomarker of recurrence into clinical practice.

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Circulating Metabolic Markers Identify Patients at Risk for Tumor Recurrence

Montcusí,

Madrid-Gambin,

Marin

et al. 2024

Annals of Surgery

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Smartphone-based paper strip assay for putrescine and spermidine detection using hybrid organic–inorganic perovskite with Eu³⁺ complex

Abstract: A new method utilizing fluorescent ratiometry is proposed for detecting putrescine and spermidine. The method involves the use of a fluorescent probe comprising a 2D halide perovskite synthesized from octadecylamine-iodine...

Cited by 1 publication

References 45 publications

Circulating Metabolic Markers Identify Patients at Risk for Tumor Recurrence

Circulating Metabolic Markers Identify Patients at Risk for Tumor Recurrence

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Smartphone-based paper strip assay for putrescine and spermidine detection using hybrid organic–inorganic perovskite with Eu3+ complex

Abstract: A new method utilizing fluorescent ratiometry is proposed for detecting putrescine and spermidine. The method involves the use of a fluorescent probe comprising a 2D halide perovskite synthesized from octadecylamine-iodine...

Cited by 1 publication

References 45 publications

Circulating Metabolic Markers Identify Patients at Risk for Tumor Recurrence

Circulating Metabolic Markers Identify Patients at Risk for Tumor Recurrence

Contact Info

Product

Resources

About

Smartphone-based paper strip assay for putrescine and spermidine detection using hybrid organic–inorganic perovskite with Eu³⁺ complex