SMC4, CCNB1 and CKS1B as potential targets and new critical biomarkers for the prognosis of human bladder cancer

Fang, Hongpeng; Huang, Zenan; Zeng, Xian-Zi; Wan, Jiaming; Wu, Jieying; Di, Jiejian

doi:10.21203/rs.3.rs-595148/v1

Cited by 1 publication

(1 citation statement)

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“…Numerous studies have reported that CCNB1 is overexpressed in many tumorshepatocellular carcinoma (27), colon cancer (28), and pancreatic cancer (29)-and promotes tumor cell proliferation. A recent study identified CCNB1 as a potential target and a new key biomarker for the prognosis of human BCa (30); this study's results confirm this. In cell cycle progression, CDC20 is an important control factor of cell cycle checkpoints.…”

Section: Discussionsupporting

confidence: 84%

Construction of a Co-Expression Network for lncRNAs and mRNAs Related to Urothelial Carcinoma of the Bladder Progression

2022

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Carcinoma of urinary bladder is the most familiar cancer of the urinary tract, with the highest incidence in men. However, its prognosis and treatment have not improved significantly in the last 30 years. The main reason for this may be related to the alteration and regulation of genes. These alterations in genes that play a crucial role in cell cycle regulation may result in high-grade tumors and may alter drug sensitivity. Notably, the role of lncRNA in bladder cancer, especially the lncRNA-mRNA regulatory network, has not been fully elucidated. In this manuscript, we compared RNA sequencing (RNA-seq) data from 19 normal bladder tissues and 411 primary bladder tumor tissues using The Cancer Genome Atlas (TCGA) data bank, subjected differentially expressed mRNAs and lncRNAs to weighted gene co-expression network analysis, and screened out modules highly correlated with tumor progression. Subsequently, a lncRNA-mRNA co-expression network was built, and two key mRNAs were identified via COX regression analysis. Kaplan-Meier curve analysis revealed that the overall survival of sick people in the high-risk section was significantly shorter than those in the low-risk section. Therefore, this lncRNA-mRNA-based co-expression pattern may be used clinically to predict the prognosis of carcinoma of urinary bladder people. Our study not only provides a genetic target for carcinoma of urinary bladder therapy but also provides new ideas for people in the medical profession to discover the treatment of various tumors.

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Section: Discussionsupporting

confidence: 84%