SMIT2 mediates all myo‐inositol uptake in apical membranes of rat small intestine

Aouameur, Rym; Cal, Sandra Da; Bissonnette, Pierre; Coady, Michael J.; Lapointe, Jean‐Yves

doi:10.1096/fasebj.22.1_supplement.1053.3

Cited by 3 publications

(4 citation statements)

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“…11 Also, inositol acted as an osmolyte in some tissues, such as kidney medulla and brain, where osmolarity has a pivotal biological meaning. 12 In addition, inositol (either in the DCI or MI isoform) has been reported to mediate glucose uptake by improving insulin sensitivity. Insulin-mimetic effects of MI or its isomers seem to be derived from inositol phosphoglycan (IPG) which contains MI or DCI.…”

Section: Introductionmentioning

confidence: 99%

“…The inositol‐dependent pathways transduce the signal of some hormones including vasopressin, thyrotropin‐releasing hormone (TRH), thyroid‐stimulating hormone (TSH), angiotensin II, and GnRH 11 . Also, inositol acted as an osmolyte in some tissues, such as kidney medulla and brain, where osmolarity has a pivotal biological meaning 12 . In addition, inositol (either in the DCI or MI isoform) has been reported to mediate glucose uptake by improving insulin sensitivity.…”

Section: Introductionmentioning

confidence: 99%

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Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials

Zarezadeh

Dehghani

Faghfouri

et al. 2021

Obesity Science & Practice

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Background: Inositol is a sugar-alcohol and recognized as a key component of cell membrane phospholipids. It has crucial role in the cell signaling pathways and contribute to improving glycemic responses. Although some earlier studies have revealed the effect of inositol mediating glucose uptake by improving insulin sensitivity, the benefit of inositol supplementation in patients with overweight and obesity is not completely understood. This study aimed to assess the impact of inositol supplementation on body mass index (BMI) through a systematic review and meta-analysis of controlled clinical trials. Methods:A systematic search was performed to August 2021 in the following databases: PubMed-Medline, Embase, Web of Science and Scopus. Fifteen controlled clinical trials investigating the effect of inositol on adult's BMI were finally included in the study. A random-effects model was employed to estimate the effect size.Subgroup analysis was performed by dose, duration, age, type of inositol. Metaregression was used to investigate presence of any linear relationship. Begg's and Egger's tests were carried out to detect small study effect. Results:The results of pooled analysis showed that inositol supplementation significantly decreased BMI scores (WMD = −0.41 kg/m 2 ; 95% CI: −0.78, −0.04; p = 0.028). Subgroup analysis was performed to identify the source of heterogeneity among studies (I 2 = 73.9%, p < 0.001), demonstrating supplementation duration, baseline BMI, mean age of participants, type of inositol and dosage were potential Meysam Zareadeh and Azadeh Dehghani have contributed equally to this work and share first authorship.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials

Zarezadeh

Dehghani

Faghfouri

et al. 2021

Obesity Science & Practice

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“…3k, l, o-q). This could be explained by the increased levels of fumarate and myo-inositol in cultivated lettuce compared to wild accessions 24,26 . The fumarate derivative, dimethyl-fumarate (DMF), has anti-inflammatory and antioxidant capacity and it can also improve the tight-junction protein expression 27 .…”

Section: Discussionmentioning

confidence: 99%

Bioengineered intestinal tubules as a tool to test intestinal biological efficacy of lettuce species

et al. 2022

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Lettuce (Lactuca sativa) is one of the most consumed and cultivated vegetables globally. Its breeding is focused on the improvement of yield and disease resistance. However, potential detrimental or beneficial health effects for the consumer are often not targeted in the breeding programs. Here, a bioengineered intestinal tubule was used to assess the intestinal efficacy of extracts from five plant accessions belonging to four Lactuca species. These four species include the domesticated L. sativa, closely related wild species L. serriola, and phylogenetically more distant wild relatives L. saligna and L. virosa. We assessed the epithelial barrier integrity, cell viability, cell attachment, brush border enzyme activity, and immune markers. Extracts from L. sativa cv. Salinas decreased cell attachment and brush border enzyme activity. However, extracts from the non-edible wild species L. saligna and L. virosa reduced the epithelial barrier functions, cell attachment, cell viability, and brush border enzyme activity. Since wild species represent a valuable germplasm pool, the bioengineered intestinal tubules could open ways to evaluate the safety and nutritional properties of the lettuce breeding material originating from crosses with wild Lactuca species.

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“…p = 0.0008 for rs28540434). SLC5A11 is expressed in the gastrointestinal tract and kidney and has been found to be responsible for apical MI transport in the rat intestine (48,49). Hence, variation in expression or function of this gene represents a plausible mechanism by which plasma MI could be modulated.…”

Section: Inositol Quantificationmentioning

confidence: 99%

Investigating Genetic Determinants of Plasma Inositol Status in Adult Humans

Weston

Pangilinan

Eaton

et al. 2022

The Journal of Nutrition

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Background Myo-inositol (MI) is incorporated into numerous biomolecules, including phosphoinositides and inositol phosphates. Disturbance of inositol availability or metabolism is associated with various disorders, including neurological conditions and cancers, while supplemental MI has therapeutic potential in conditions such as depression, polycystic ovary syndrome and congenital anomalies. Inositol status may be influenced by diet, synthesis, transport, utilisation and catabolism. Objectives We aimed to investigate potential genetic regulation of circulating MI status and to evaluate correlation of MI concentration with other metabolites. Methods Gas chromatography mass spectrometry was used to determine plasma MI concentration of more than 2,000 healthy, young adults (aged 18–28 years) from the Trinity Student Study. Genotyping data was used to test association of plasma MI with SNPs in candidate genes, encoding inositol transporters and synthesising enzymes, and test for genome-wide association. We evaluated potential correlation of plasma MI with D-chiro inositol, glucose and other metabolites by Spearman's rank correlation. Results Mean plasma MI showed a small but significant difference between males and females (28.5 and 26.9 µM, respectively). Candidate gene analysis revealed several nominally significant associations with plasma MI, most notably for SLC5A11, encoding a sodium-coupled inositol transporter, also known as SMIT2 (sodium-dependent myo-inositol transporter 2). However, these did not survive correction for multiple testing. Subsequent testing for genome-wide association with plasma MI did not identify associations of genome-wide significance (p < 5 × 10–8). However, 8 SNPs exceeded the threshold for suggestive significant association with plasma MI concentration (p < 1 × 10–5), 3 of which were located within or close to genes: MTDH, LAPTM4B and ZP2. We found significant positive correlation of plasma MI concentration with concentration of D-chiro-inositol and several other biochemicals including glucose, methionine, betaine, sarcosine and tryptophan. Conclusion Our findings suggest potential for modulation of plasma MI in young adults by variation in SLC5A11 which is worthy of further investigation.

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SMIT2 mediates all myo‐inositol uptake in apical membranes of rat small intestine

Cited by 3 publications

References 0 publications

Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials

Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials

Bioengineered intestinal tubules as a tool to test intestinal biological efficacy of lettuce species

Investigating Genetic Determinants of Plasma Inositol Status in Adult Humans

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