In this study, the issues of complicated interactions between process variables were solved by decoupling techniques; in particular, simplified decoupling was used due to its simplicity and robustness. A new approach to solving decoupling realizability was developed by using the modified particle swarm optimization (PSO) algorithm. However, time delays still existed in the diagonal elements of the decoupled matrix, and they resulted in a more sophisticated controller design and sluggish responses in the outputs. To overcome the adverse effects of time delays, a Smith predictor, also known as a dead time compensator, is normally used. In this work, a Smith predictor structure in combination with simplified decoupling for multivariable processes was proposed in order to enhance system performances in terms of the servomechanism problem. The proportional integral or proportional integral derivative (PI/PID) controller tuning rules for several common industrial processes, such as first-order, second-order, and second-order with negative zero systems, were obtained. Many multivariable industrial processes were adopted to simulate the effectiveness of the proposed method in terms of the servomechanism problem and robust response.