Smokeless tobacco consumption induces dysbiosis of oral mycobiome: a pilot study

Sajid, Mohammad; Sharma, Pragya; Srivastava, Sonal; Hariprasad, Roopa; Singh, Harpreet; Bharadwaj, Mausumi

doi:10.1007/s00253-022-12096-6

Cited by 6 publications

(5 citation statements)

References 69 publications

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“…A plethora of studies have supported this claim, especially in oral health and malignant, tobacco abuse, cancer therapy and nutrition [ 4 , 26 , 27 ]. However, knowledge of the role of oral microbiota in the initiation and development of OSCC is still at its infancy, as there is currently no consensus among researchers on the dysbiotic nature of oral microbiota for diagnosis and screening of OSCC.…”

Section: Discussionmentioning

confidence: 99%

Microbiome analysis of saliva from oral squamous cell carcinoma (OSCC) patients and tobacco abusers with potential biomarkers for oral cancer screening

Oyeyemi,

Kaur,

Paramraj

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Microbiome analysis of saliva from oral squamous cell carcinoma (OSCC) patients and tobacco abusers with potential biomarkers for oral cancer screening

Oyeyemi,

Kaur,

Paramraj

et al. 2023

Heliyon

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“…Li et al, 2019). In a recent study alteration of the oral mycobiota caused by smoking tobacco showed a decreased oral fungal diversity and an increase of the Pichia genus correlated with the severity of oral lesions (Sajid et al, 2022).…”

Section: Oral Tractmentioning

confidence: 96%

“…Significantly higher abundances of the genus Candida were observed in patients with erosive oral lichen planus (Y. Li et al, 2019). In a recent study alteration of the oral mycobiota caused by smoking tobacco showed a decreased oral fungal diversity and an increase of the Pichia genus correlated with the severity of oral lesions (Sajid et al, 2022).…”

Section: The Human Mycobiota: Richness and Diversity In The Human Bod...mentioning

confidence: 99%

Ascomycetes yeasts: The hidden part of human microbiome

Nenciarini,

Renzi,

di Paola

et al. 2024

WIREs Mechanisms of Disease

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The fungal component of the microbiota, the mycobiota, has been neglected for a long time due to its poor richness compared to bacteria. Limitations in fungal detection and taxonomic identification arise from using metagenomic approaches, often borrowed from bacteriome analyses. However, the relatively recent discoveries of the ability of fungi to modulate the host immune response and their involvement in human diseases have made mycobiota a fundamental component of the microbial communities inhabiting the human host, deserving some consideration in host–microbe interaction studies and in metagenomics. Here, we reviewed recent data on the identification of yeasts of the Ascomycota phylum across human body districts, focusing on the most representative genera, that is, Saccharomyces and Candida. Then, we explored the key factors involved in shaping the human mycobiota across the lifespan, ranging from host genetics to environment, diet, and lifestyle habits. Finally, we discussed the strengths and weaknesses of culture‐dependent and independent methods for mycobiota characterization. Overall, there is still room for some improvements, especially regarding fungal‐specific methodological approaches and bioinformatics challenges, which are still critical steps in mycobiota analysis, and to advance our knowledge on the role of the gut mycobiota in human health and disease.This article is categorized under: Immune System Diseases > Genetics/Genomics/Epigenetics Immune System Diseases > Environmental Factors Infectious Diseases > Environmental Factors

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“…Candida albicans represented 58% of the uninfected oral mycobiome but 83% of the HIV-infected oral mycobiome, with a decrease represented in the abundance of Pichia , which was deemed a consequence of antagonistic effects [ 9 ]. Lifestyle choices are another factor that can affect the oral mycobiome, such as smokeless tobacco use, which has been shown to significantly decrease the richness and diversity of the mycobiome, causing a dominance of the genus Pichia , similar to the HIV study results, and leading to dysbiosis linked to oral cancer [ 10 ]. Even factors such as saliva levels, oral pH, and, interestingly, denture use have all been linked to oral mycobiome composition shifts, with low salivary flow, low pH, and the presence of dentures all being associated with an increase in Candida species [ 11 , 12 ].…”

Section: Oral Mycobiomementioning

confidence: 99%

The Role of the Mycobiome in Women’s Health

Esposito

Patsakos

Borruso

2023

JoF

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Although the human bacteriome and virome have gained a great deal of attention over the years, the human mycobiome has been far more neglected despite having significant value and implications in human health. In women, mycobiome profiles in breastmilk, vaginal regions, the gut, skin, and the oral cavity can provide insight into women’s health, diseases, and microbiome dysbiosis. Analyses of mycobiome composition under factors, such as health, age, diet, weight, and drug exposure (including antibiotic therapies), help to elucidate the various roles of women’s mycobiome in homeostasis, microbiome interactions (synergistic and antagonistic), and health. This review summarizes the most recent updates to mycobiome knowledge in these critical areas.

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Smokeless tobacco consumption induces dysbiosis of oral mycobiome: a pilot study

Cited by 6 publications

References 69 publications

Microbiome analysis of saliva from oral squamous cell carcinoma (OSCC) patients and tobacco abusers with potential biomarkers for oral cancer screening

Microbiome analysis of saliva from oral squamous cell carcinoma (OSCC) patients and tobacco abusers with potential biomarkers for oral cancer screening

Ascomycetes yeasts: The hidden part of human microbiome

The Role of the Mycobiome in Women’s Health

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