Smokers' sex and the effects of tobacco cigarettes: Subject-rated and physiological measures

Eissenberg, Thomas; Adams, C.H.; Riggins, Earl C.; Likness, Mark

doi:10.1080/14622299050011441

Cited by 101 publications

(87 citation statements)

References 33 publications

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“…The TCQ data showed the same pattern; only women reported significantly less tobacco craving following nicotine administration across Nicotine effects on mood and cognition CS Myers et al sessions. Similarly, Eissenberg et al (1999) found that, after smoking two cigarettes, women reported significantly less desire to smoke than men. Others also have noted sex differences in subjective response to nicotine.…”

Section: Discussionmentioning

confidence: 88%

“…For example, File et al (2001) reported that women nonsmokers reported feeling less physically tired and men more tired after receiving 2 mg intranasal nicotine. Eissenberg et al (1999) found that, after smoking, women reported significantly less restlessness, sedation, and difficulty concentrating than men. Women have reported more positive subjective responses to nicotine when it was administered by smoking compared with nasal spray (Perkins et al, 1994).…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Dose-Related Enhancement of Mood and Cognition in Smokers Administered Nicotine Nasal Spray

Myers

Taylor

Moolchan

et al. 2007

Neuropsychopharmacol

126

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The discovery of the role of nicotinic receptors in attention and memory has led to the testing of nicotinic analogs as cognitive enhancing agents in patient populations. Empirical information about nicotine's ability to enhance elements of attention and memory in normal individuals might guide development of therapeutic uses of nicotine in cognitively impaired populations. The purpose of this study was to determine the effect of nicotine on continuous attention, working memory, and computational processing in tobacco-deprived and nondeprived smokers. A total of 28 smokers (14 men, 14 women) participated in a double-blind, placebo-controlled, within-subject study, in which they were overnight (12 h) tobacco deprived at one session and smoked ad libitum before the other session. At each session, participants received 0, 1, and 2 mg nicotine via nasal spray in random order at 90 min intervals. Before and after each dose, a battery of cognitive, subjective, and physiological measures was administered, and blood samples were taken for plasma nicotine concentration. Overnight tobacco deprivation resulted in impaired functioning on all cognitive tests and increased self-reports of tobacco craving and negative mood; nicotine normalized these deficits. In the nondeprived condition, nicotine enhanced performance on the continuous performance test (CPT) and an arithmetic test in a dose-related manner, but had no effect on working memory. In general, women were more sensitive than men to the subjective effects of nicotine. These results provide an unequivocal determination that nicotine enhanced attentional and computational abilities in nondeprived smokers and suggest these cognitive domains as substrates for novel therapeutic indications.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 94%

Dose-Related Enhancement of Mood and Cognition in Smokers Administered Nicotine Nasal Spray

Myers

Taylor

Moolchan

et al. 2007

Neuropsychopharmacol

126

View full text Add to dashboard Cite

show abstract

“…Although findings for Factor 2 of the QSU-Brief were not significant, there is growing evidence that assessing multiple aspects of urges allows for a more thorough measurement of this construct. Indeed, there are numerous studies that have revealed differential outcomes across both factors of the QSU (Burton and Tiffany, 1997;Corrigall et al, 2001;Eissenberg et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Subjective reactivity to the first cigarette of the day as a predictor of smoking relapse: A preliminary study

Toll¹,

Schepis²,

O’Malley³

et al. 2007

Drug and Alcohol Dependence

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We examined subjective responses to smoking the first cigarette of the day and investigated how these responses related to smoking cessation treatment outcome. Data from participants (N = 207) in a clinical trial of message framing for smoking cessation with bupropion, obtained prior to the targeted quit day, were used to examine indices of craving, withdrawal, and affect before and after smoking the first cigarette of the day. After smoking the initial cigarette, craving, withdrawal symptoms, and negative affect were lessened, and positive affect increased. Greater decreases in craving as measured by the Questionnaire on Smoking Urges-Brief (QSU-Brief) predicted relapse at the end of treatment (6 weeks) and at the 3 month follow-up time point. These associations do not appear to be mediated by established measures of dependence. Thus, this preliminary study provides evidence that there are significant changes in craving, withdrawal, and affect related to smoking the first cigarette of the day, with the largest of these changes observed for craving. Moreover, changes in tobacco craving in response to the first cigarette of the day may be a novel predictor of smoking relapse that should be tested in future studies.

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“…Taken together with duration, puff velocity determines puff volume that predicts nicotine delivery in cigarette smokers. 24 The average puff velocity of tobacco cigarette smokers is generally 29-38 ml/s 18,28,29 though experienced ECIG users may draw lower puff velocities. 30 To date, no study has examined the combined influence of puff duration and velocity on nicotine yield in ECIG aerosol.…”

Section: Introductionmentioning

confidence: 99%

Effects of User Puff Topography, Device Voltage, and Liquid Nicotine Concentration on Electronic Cigarette Nicotine Yield: Measurements and Model Predictions

Talih

Balhas

Eissenberg

et al. 2014

Nicotine &Amp; Tobacco Research

Self Cite

315

341

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Introduction: Some electronic cigarette (ECIG) users attain tobacco cigarette-like plasma nicotine concentrations while others do not. Understanding the factors that influence ECIG aerosol nicotine delivery is relevant to regulation, including product labeling and abuse liability. These factors may include user puff topography, ECIG liquid composition, and ECIG design features. This study addresses how these factors can influence ECIG nicotine yield. Methods: Aerosols were machine generated with 1 type of ECIG cartridge (V4L CoolCart) using 5 distinct puff profiles representing a tobacco cigarette smoker (2-s puff duration, 33-ml/s puff velocity), a slow average ECIG user (4 s, 17 ml/s), a fast average user (4 s, 33 ml/s), a slow extreme user (8 s, 17 ml/s), and a fast extreme user (8 s, 33 ml/s). Output voltage (3.3-5.2 V or 3.0-7.5 W) and e-liquid nicotine concentration (18-36 mg/ml labeled concentration) were varied. A theoretical model was also developed to simulate the ECIG aerosol production process and to provide insight into the empirical observations. Results: Nicotine yields from 15 puffs varied by more than 50-fold across conditions. Experienced ECIG user profiles (longer puffs) resulted in higher nicotine yields relative to the tobacco smoker (shorter puffs). Puff velocity had no effect on nicotine yield. Higher nicotine concentration and higher voltages resulted in higher nicotine yields. These results were predicted well by the theoretical model (R 2 = 0.99). Conclusions: Depending on puff conditions and product features, 15 puffs from an ECIG can provide far less or far more nicotine than a single tobacco cigarette. ECIG emissions can be predicted using physical principles, with knowledge of puff topography and a few ECIG device design parameters.

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Smokers' sex and the effects of tobacco cigarettes: Subject-rated and physiological measures

Cited by 101 publications

References 33 publications

Dose-Related Enhancement of Mood and Cognition in Smokers Administered Nicotine Nasal Spray

Dose-Related Enhancement of Mood and Cognition in Smokers Administered Nicotine Nasal Spray

Subjective reactivity to the first cigarette of the day as a predictor of smoking relapse: A preliminary study

Effects of User Puff Topography, Device Voltage, and Liquid Nicotine Concentration on Electronic Cigarette Nicotine Yield: Measurements and Model Predictions

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