Smoking and adult glioma: a population-based case-control study in China

Hou, Lei; Jiang, Jingmei; Liu, Boqi; Han, Wei; Wu, Yanping; Zou, Xin; Nasca, Philip C.; Xue, Fang; Chen, Yuanli; Zhang, Biao; Pang, Haiyu; Wang, Yuyan; Wang, Zixing; Li, Junyao

doi:10.1093/neuonc/nov146

Cited by 23 publications

(31 citation statements)

References 26 publications

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“… 22 The final analysis in this study included a total of 24 studies from 22 articles. 11 – 25 , 43 – 49 The selection process is shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Of the 24 studies included, seven were cohort studies 12 , 17 – 21 , 43 and the remaining 17 were case–control studies. 11 , 13 – 16 , 22 – 25 , 44 – 49 All together, these studies involved >2.3 million individuals. Among these studies, 13 were conducted in the USA, 12 – 15 , 17 , 19 – 22 , 44 , 46 four in Europe, 17 , 24 , 47 , 48 three in Canada, 23 , 43 , 45 two in Australia, 11 , 16 and two in the People’s Republic of China.…”

Section: Resultsmentioning

confidence: 99%

“… 17 – 21 A meta-analysis of 17 studies in 2009 failed to show significant association, but a small and significant increased risk was noted in a cohort study. 7 Recently, a series of cohort studies and case–control studies have been published, 21 – 25 again, with conflicting results. In particular, a recent large population-based case–control study involving >13,000 individuals in the People’s Republic of China supported a positive association between cigarette smoking and gliomas.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, a recent large population-based case–control study involving >13,000 individuals in the People’s Republic of China supported a positive association between cigarette smoking and gliomas. 25 As a result, a reanalysis is appropriate.…”

Section: Introductionmentioning

confidence: 99%

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Cigarette smoking and risk of adult glioma: a meta-analysis of 24 observational studies involving more than 2.3 million individuals

Peng

Zong

et al. 2016

OTT

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BackgroundCigarette smoking has been shown to be a risk factor for adult glioma by some but not all studies. We conducted a meta-analysis to systematically assess the potential association.MethodsPubMed and EMBASE were searched from the date of their inception to October 1, 2015, to identify relevant articles. Reference lists from these articles were reviewed to identify additional studies. Both cohort and case–control studies were included. Fixed-effects models were used to calculate the overall relative risk (RR) with corresponding 95% confidence intervals (CIs).ResultsThe final analysis included 24 studies (seven cohort and 17 case–control studies), involving more than 2.3 million individuals. The combined RR was 1.04 (95% CI: 1.00, 1.09; P=0.073) for ever-smokers, 0.97 (95% CI: 0.88, 1.07; P=0.574) for current-smokers, and 1.07 (95% CI: 0.98, 1.16; P=0.130) for past smokers, with little evidence of heterogeneity. Omission of any single study from the analysis had little effect on the result. No evidence of publication bias was found. A small but statistically significant increase was found in past smokers in females (RR: 1.13, 95% CI: 1.00, 1.28; P=0.046) but not in males.ConclusionIn general, there was no association between cigarette smoking and adult glioma. The small but statistically significant association in females requires further investigation.

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“… 22 The final analysis in this study included a total of 24 studies from 22 articles. 11 – 25 , 43 – 49 The selection process is shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cigarette smoking and risk of adult glioma: a meta-analysis of 24 observational studies involving more than 2.3 million individuals

Peng

Zong

et al. 2016

OTT

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“…GBM is listed as the most prevalent type of cancer in China, and its incidence is rising every year, and will remain to advance in the coming years [19]. So far, the prognosis of GBM is still very poor.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Silencing hsa_circ_PVT1 (circPVT1) suppresses the growth and metastasis of glioblastoma multiforme cells by up-regulation of miR-199a-5p

Chi

Yang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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2020) Silencing hsa_circ_PVT1 (circPVT1) suppresses the growth and metastasis of glioblastoma multiforme cells by up-regulation of miR-ABSTRACT Background: Glioblastoma multiforme (GBM) is one of the most prevailing primary brain tumours among adults and most aggressive cancers. Despite multiple developments in medical and surgical treatments, GBM is still a deadly disease with a high mortality rate. Here, this study was performed to investigate the function of circPVT1 on GBM. Methods: CCK-8 and flow cytometry were utilised to estimate viability and apoptosis in both cells. qRT-PCR was performed to determine circPVT1 and miR-199a-5p expression. Western blot was conducted to determine apoptosis, migration and EMT-related proteins levels when silencing circPVT1. Subsequently, these parameters were re-tested after up-regulating miR-199a-5p. Results: CircPVT1 was highly expressed in GBM tissues. Silencing circPVT1 raised two cells apoptosis and reduced viability and migration capacity. Moreover, EGF-induced EMT was repressed by silencing circPVT1. In addition, miR-199a-5p expression was elevated when silencing circPVT1. And silencing circPVT1 exerted above changes via up-regulating miR-199a-5p. Finally, silencing circPVT1 repressed YAP1 and PI3K/AKT pathways via up-regulating miR-199a-5p. Conclusion: Our data suggested that silencing circPVT1 inhibited viability, migration, EGF-induced EMT and promoted apoptosis as well as repressed YAP1 and PI3K/AKT pathways by up-regulating miR-199a-5p. HIGHLIGHTS 1. CircPVT1 expression is highly expressed in GBM tissues; 2. Si-circPVT1 represses migration and promoted apoptosis in U539 and U251 cells; 3. Si-circPVT1 represses migration and promoted apoptosis when elevating miR-199a-5p; 4. Si-circPVT1 represses EGF-induced EMT when increasing miR-199a-5p; 5. Si-circPVT1 suppresses YAP1 and PI3K/AKT pathways by up-regulating miR-199-5p. ARTICLE HISTORY

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Progress in the molecular pathology of glioma

柯昌庶

2016

Oncology and Translational Medicine

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Changshu Ke, Associate Professor of Pathology, Masters Supervisor, Associate Director of the Department of Pathology, Tongji Hospital, Tongji Medical College of HUST, China. Prof. Ke graduated from The Fourth Military Medical University in 1986 and obtained his Master’s degree in the Department of Pathology, PLA General Hospital (Beijing), in 1989. In 1995, he received a fellowship for training in surgical pathology supported by the Hong Kong Division of the International Association of Pathology, which was held at the Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong. From 1997 to 2001, he studied in the Faculty of Medicine, The Chinese University of Hong Kong, and obtained his doctorate in 2001. He is now in charge of clinical services at the Department of Pathology, Tongji Hospital, Tongji Medical College, HUST. In addition, he teaches the pathology courses for medical students, and overseas medical students and graduate students (neuropathology courses). His research is mainly focused on brain edema, the surgical pathology of CNS tumors, and experimental studies in tumor biology. His current academic activities include: member of the editorial board of the Chinese Journal of Clinical Neurosurgery, member of the Neuropathology Group of the Pathological Society of the Chinese Medical Association, member of the Standing Committee of Onco-pathology Specialty of Chinese Anti-Cancer Association, and vice chairman of the Standing Committee of Onco-pathology Specialty of Hubei Anti-Cancer Association.

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Smoking and adult glioma: a population-based case-control study in China

Abstract: This study indicates that smoking is associated with glioma deaths in the Chinese population. Long-term heavy smoking could be a factor for risk stratification in individuals attending brain tumor clinics.

Cited by 23 publications

References 26 publications

Cigarette smoking and risk of adult glioma: a meta-analysis of 24 observational studies involving more than 2.3 million individuals

Cigarette smoking and risk of adult glioma: a meta-analysis of 24 observational studies involving more than 2.3 million individuals

RETRACTED ARTICLE: Silencing hsa_circ_PVT1 (circPVT1) suppresses the growth and metastasis of glioblastoma multiforme cells by up-regulation of miR-199a-5p

Progress in the molecular pathology of glioma

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