“…In contrast, others scholars have explicitly concluded that the analysis of variance provides indispensable information for understanding place effects on health (Boyle MH & Willms JD, 1999;Clarke P & Wheaton B, 2007;Duncan et al, 1993;Merlo, 2003;Merlo et al, 2004;Merlo et al, 2009;Riva et al, 2007) Moreover, all around the world, a persistent amount of observational information on place effects is still being obtained from ecological/spatial studies of "small-area variations" , frequently in the form of coloured atlases and disease maps (Benach et al, 2003;Benach et al, 2004;Borrell et al, 2010;Collaboration, 2010;MacNab & Dean, 2002;Middleton et al, 2008;Ocana-Riola & Mayoral-Cortes, 2010;Ocana-Riola et al, 2008a;Pickle et al, 1999;Shaw, 2008;Turrell & Mengersen, 2000). From an empirical perspective, the advantages of multilevel versus ecological regression analyses were clearly identified by the seminal work performed by Aitkins and Longford (Aitkin M & Longford N, 1986) as well as by Jones,4 Duncan, Moon, Subramanian and colleagues (Bullen et al, 1996;Duncan et al, 1993Duncan et al, , 1995Duncan et al, , 1996Duncan et al, , 1998Duncan et al, , 1999Jones et al, 1991;Subramanian et al, 2009;Twigg et al, 2000). We also contributed to this discussion in a previous publication (Merlo et al, 2001).…”