Smoking and Pancreatic Cancer: Smoking Patterns, Tobacco Type, and Dose-Response Relationship

Subhan, Muhammad; Parel, Nisha Saji; Krishna, Parimi Vamsi; Gupta, A.; Uthayaseelan, Kamsika; Uthayaseelan, Kivonika; Kadari, Monika

doi:10.7759/cureus.26009

Cited by 7 publications

(9 citation statements)

References 46 publications

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“…In addition, the number of years smoking was negatively correlated with the survival rate of pancreatic cancer patients [20]. Of the 7,000 chemicals found in tobacco smoke, at least 250 are harmful, and 60 are carcinogenic [5]. Cigarette smoke promotes the metastasis of pancreatic cancer by upregulating the expression of MUC4 in pancreatic cancer tissue [21].…”

Section: Discussionmentioning

confidence: 99%

“…The modifiable risk factors for pancreatic cancer include behavioral factors and metabolic factors. Cigarette smoking is a well-established behavioral risk factor for various cancers, such as tracheal, bronchus and lung cancer, laryngeal cancer, head and neck squamous cell carcinomas, esophageal cancer, colorectal cancer and pancreatic cancer [2][3][4][5][6][7]. Smoking was the second leading risk factor for mortality in both sexes in 2015 [8].…”

Section: Introductionmentioning

confidence: 99%

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The Global, Regional and National Burden of Pancreatic Cancer Attributable to Smoking, 1990 to 2019: A Systematic Analysis from the Global Burden of Disease Study 2019

Jiang

Xiang

et al. 2023

IJERPH

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Objective: Pancreatic cancer poses a serious medical problem worldwide. Studies have reported the relationship between smoking and cancer. This study aimed to evaluate the burden of pancreatic cancer attributable to smoking and its global, regional and national trends, patterns and alterations from 1990 to 2019. Methods: Data were extracted from the Global Health Data Exchange query tool, including deaths, disability-adjusted life-years (DALYs) and age-standardized rates (ASRs). Measures were stratified by sex, age, region, country/territory and sociodemographic index (SDI). We used Joinpoint regression to determine the secular trend of ASRs by calculating the average annual percentage change (AAPC). Results: In 2019, smoking risk-related deaths and DALYs accounted for 21.3% and 21.1% of global pancreatic cancer, respectively. There were 113,384 (95% UI 98,830 to 128,466) deaths of smoking-attributable pancreatic cancer worldwide in 2019, of which 64.1% were in males. The disease burden was higher in males than in females. High-income regions or large population regions had the higher disease burden. East Asia carried the highest number of smoking-attributable pancreatic cancer deaths and DALYs. The Caribbean had the fastest increasing rate (AAPC = 3.849, 95% CI 3.310 to 4.391) of age-standardized death rate over the past 30 years. In 2019, China had the highest number of deaths, which was followed by the USA and Japan. There was a trend of increasing ASDR along with increases in SDI. Conclusion: Variations existed in the smoking risk-related pancreatic cancer burden among different sexes, age groups, regions and countries/territories. The burden of smoking-attributable pancreatic cancer should be considered an important health issue. Future strategies should include comprehensive policies to control tobacco use.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Global, Regional and National Burden of Pancreatic Cancer Attributable to Smoking, 1990 to 2019: A Systematic Analysis from the Global Burden of Disease Study 2019

Jiang

Xiang

et al. 2023

IJERPH

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“…Our findings on smoking and PC risk are consistent with previous population-based studies showing that current and passive smoking were associated with an increased risk of PC. 9,[18][19][20][21][22] A recent metaanalysis on the association between smoking and PC risk found a higher risk for current smokers than non-smokers. 23 Similarly, largescale studies from Europe 24 and Asia 25 showed that smoking is associated with a 2-fold increased risk of PC.…”

Section: Discussionmentioning

confidence: 99%

“…Among them, tobacco use is, to the present knowledge, the most important one. Indeed, a recent review by Subhan et al 9 . showed that smoking is a strong risk factor for PC, leading to progressive fibrosis of the pancreatic glandular tissue and stroma.…”

Section: Introductionmentioning

confidence: 99%

“…Among them, tobacco use is, to the present knowledge, the most important one. Indeed, a recent review by Subhan et al 9 showed that smoking is a strong risk factor for PC, leading to progressive fibrosis of the pancreatic glandular tissue and stroma. However, the potential effect of passive smoking has been little investigated so far, especially regarding passive smoking in childhood.…”

Section: Introductionmentioning

confidence: 99%

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Childhood and adulthood passive and active smoking, and the ABO group as risk factors for pancreatic cancer in women

Vedie,

Laouali,

Gelot

et al. 2023

UEG Journal

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ObjectivesActive smoking and the A blood group are associated with pancreatic adenocarcinoma (PC) risk. However, potential interactions between those risk factors and the role of passive smoking have been little investigated. We aimed to explore specific and joint associations of passive and active smoking, and effect modification by the ABO blood group in French women.MethodsThe study included 96,594 women from the E3N prospective cohort, mean age: 49 years (SD 6.7). Information on active and passive smoking was reported at inclusion and throughout follow‐up. Cases were classified according to the International Classification of Diseases 10. Associations with passive and active smoking and effect modification by the ABO blood group were investigated with multivariable Cox regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI).ResultsDuring a 24‐year median follow‐up, 346 incident PC cases were identified. Current smoking compared with never and former smoking (HR 1.51 [95% CI 1.08–2.10]), and passive smoking in childhood compared with no childhood exposure (HR 1.47 [95% CI 1.08–2.00]) were associated with increased PC risk, but not passive exposure in adulthood (HR 1.16 [95% CI 0.91–1.47]). Exposure to both passive smoking in childhood and current smoking was associated with a stronger risk (HR 2.80 [95% CI 1.42–5.52]) than exposure to both current smoking and passive smoking only in adulthood (HR 1.68 [95% CI 1.10–2.57]) compared with neither passive nor active smoking. Associations between active smoking and PC risk were strongest in the O or B groups, while associations with passive smoking were strongest in the A or AB blood groups, but the interaction terms were not statistically significant.ConclusionsBoth current smoking and passive smoking in childhood were associated with PC risk, with a maximal risk of current smokers exposed to passive smoking during childhood. Possible interactions between blood groups and active or passive smoking must be investigated in a larger series.

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α7 nicotinic acetylcholine receptor interaction with G proteins in breast cancer cell proliferation, motility, and calcium signaling

Öz¹,

King²,

Yang³

et al. 2023

PLoS ONE

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Chronic smoking is a primary risk factor for breast cancer due to the presence of various toxins and carcinogens within tobacco products. Nicotine is the primary addictive component of tobacco products and has been shown to promote breast cancer cell proliferation and metastases. Nicotine activates nicotinic acetylcholine receptors (nAChRs) that are expressed in cancer cell lines. Here, we examine the role of the α7 nAChR in coupling to heterotrimeric G proteins within breast cancer MCF-7 cells. Pharmacological activation of the α7 nAChR using choline or nicotine was found to increase proliferation, motility, and calcium signaling in MCF-7 cells. This effect of α7 nAChR on cell proliferation was abolished by application of Gαi/o and Gαq protein blockers. Specifically, application of the Gαi/o inhibitor pertussis toxin was found to abolish choline-mediated cell proliferation and intracellular calcium transient response. These findings were corroborated by expression of a G protein binding dominant negative nAChR subunit (α7345-348A), which resulted in significantly attenuating calcium signaling and cellular proliferation in response to choline. Our study shows a new role for G protein signaling in the mechanism of α7 nAChR-associated breast cancer growth.

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Smoking and Pancreatic Cancer: Smoking Patterns, Tobacco Type, and Dose-Response Relationship

Cited by 7 publications

References 46 publications

The Global, Regional and National Burden of Pancreatic Cancer Attributable to Smoking, 1990 to 2019: A Systematic Analysis from the Global Burden of Disease Study 2019

The Global, Regional and National Burden of Pancreatic Cancer Attributable to Smoking, 1990 to 2019: A Systematic Analysis from the Global Burden of Disease Study 2019

Childhood and adulthood passive and active smoking, and the ABO group as risk factors for pancreatic cancer in women

α7 nicotinic acetylcholine receptor interaction with G proteins in breast cancer cell proliferation, motility, and calcium signaling

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