Smoking and Serologic Abnormalities

Abstract

The study determined

Cigarette Smoking and Hemagglutination Inhibition Response to Influenza after Natural Disease and Immunization1

“…Indeed, after vaccination cigarette smokers seemed to diminish their prevaccination HI deficit. Increased infection and an adequate, if not hyperactive, humoral antibody response were consistent with the previous observation that C-reactive protein was increased among cigarette smokers (21).…”

C‐reactive Protein in a Random Sample of Swedish Men Aged Fifty

“…The prevalence rate of sera with CRP concentrations exceeding 4.2 pg/ml increased with increased tobacco consumption (Table I), whereas the prevalence rates of sera with trace amounts and with no demonstrable CRP decreased with increasing tobacco consumption. These results are in accord with those reported by Heiskell et al (6). These authors demonstrated a certain relationship in males between smoking and the presence of CRP.…”

“…However, the present study indicates the usefulness of a quantitative determination of CRP, at least when sufficiently sensitive techniques are used. As regards the cause of this relationship an excessive morbidity "due to a wide variety of etiologically unrelated diseases" in smokers has been considered (6). Since the occurrence of CRP seems to be intimately related to inflammatory conditions it seems most probable that the chronic bronchitis accompanying smoking may be of importance in this connection.…”

The effect of cigarette smoking on susceptibility to epidemic influenza and on serological responses to live attenuated and killed subunit influenza vaccines

“…In man, cigarette smoking has been shown to lead to significant amounts of Creactive protein in the serum, an abnormal protein associated with inflammatory or invasive neoplastic diseases (Heiskell, Miller, Aldrich & Carpenter, 1962). Titres of non-specific agglutinins were depressed in smokers' sera relative to non-smokers (Fletcher, Sumney, Langkamp & Platt, 1969), together with depressed level of humoral IgG (Vos-Brat & Riimke, 1969).…”