Smoking and subsequent risk of acute myeloid leukaemia: A pooled analysis of 9 cohort studies in Japan

Ugai, Tomotaka; Matsuo, Keitaro; Oze, Isao; Ito, Hidemi; Wakai, Kenji; Wada, Keiko; Nagata, Chisato; Nakayama, Tomio; Liu, Rong; Kitamura, Yuri; Tamakoshi, Akiko; Tsuji, Ichiro; Sugawara, Yumi; Sawada, Norie; Sadakane, Atsuko; Tanaka, Keitaro; Mizoue, Tetsuya; Inoue, Manami; Tsugane, Shoichiro; Shimazu, Taichi

doi:10.1002/hon.2457

Cited by 13 publications

(9 citation statements)

References 36 publications

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“…Because smoking is an established risk factor for AML and MDS and our participants with higher coffee consumption were more likely to smoke, detailed adjustment for smoking as a confounder was important. Stratified analysis by smoking status suggested a possible protective effect of coffee for AML among never smoking men, although the results were not statistically significant (Supporting Information Table S1).…”

Section: Discussionmentioning

confidence: 99%

Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan

Ugai

Matsuo

Sawada³

et al. 2017

Intl Journal of Cancer

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Although coffee and green tea are suggested to reduce the risk of some types of cancers, only a few epidemiological studies have investigated their effect on the risk of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Here, we investigated the association of coffee and green tea consumption and the risk of AML and MDS in a large-scale population-based cohort study in Japan. A total of 95,807 Japanese subjects (45,937 men and 49,870 women; age 40-69 years at baseline) were followed to the end of 2012, for an average of 18 years. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the association between coffee and green tea consumption at baseline and the risk of AML and MDS were assessed using a Cox proportional hazards model with adjustment for potential confounders. During 1,751.956 person-years, we identified 85 AML cases and 70 MDS cases. Our findings showed no significant association between coffee consumption and the risk of AML, or between green tea consumption and the risk of AML or MDS. In contrast, we observed a decreasing dose-response relationship between coffee consumption and the risk of MDS among men (almost none: reference, 1-4 times/week: HR = 0.83, 95% CI: 0.43-1.62; ≥1cups/day: HR = 0.47, 0.22-0.99, p for trend = 0.049). Stratified analysis by smoking status suggested that the observed relative risk for AML and MDS of coffee drinkers relative to non-coffee drinkers might be due to residual confounding by smoking. These findings deserve further investigation in future studies.

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Section: Discussionmentioning

confidence: 99%

Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan

Ugai

Matsuo

Sawada³

et al. 2017

Intl Journal of Cancer

Self Cite

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“…Using data from 23 studies, Fircanis et al (2014) calculated a 40% and 25% increased risk of AML in current and former smokers, respectively, compared to nonsmokers. Pooling data from nine Japanese cohort studies, Ugai et al also showed an increased risk of near 40% for current smokers, and a 66% increase for ever-smokers with a history of more than 30 pack-years compared to nonsmokers (Ugai et al 2018). Although findings for environmental chemical exposures are less consistent, benzene is a well-established risk factor and has been recognized by the IARC as a cause of AML (International Agency for Research on Cancer 1987;Khalade et al 2010;Carlos-Wallace et al 2016;Raaschou-Nielsen et al 2018).…”

Section: Adult Leukemias and Lymphomas Acute Myeloid Leukemiamentioning

confidence: 99%

Epidemiology and Etiology of Leukemia and Lymphoma

Bispo

Pinheiro

Kobetz

2019

Cold Spring Harb Perspect Med

174

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Available evidence suggests that the incidence of leukemia and lymphoma tends to be higher in highly developed regions of the world and among Whites in the United States. Temporal trends in incidence are dynamic and multifactorial; for instance, the incidence of non-Hodgkin's lymphoma increased around the turn of the century, in part because of the acquired immune deficiency syndrome (AIDS) epidemic. Most leukemias and lymphomas are sporadic and the specific etiology remains elusive. Still, research shows that these malignancies often develop in the context of genetic abnormalities, immunosuppression, and exposure to risk factors like ionizing radiation, carcinogenic chemicals, and oncogenic viruses. The prognosis varies by subtype, with poorer survival outcomes for acute leukemias among adults, and more favorable outcomes for Hodgkin's lymphoma. At a time when specific prevention efforts targeting these malignancies are nonexistent, there is a great need to ensure equitable access to diagnostic services and treatments worldwide.

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“…The prior cancer site was identified for the most recent prior cancer. We categorized the following prior cancers as smoking-related cancers based on previous studies [21][22][23][24][25]: mouth, pharynx, larynx, lung, esophagus, stomach, liver, pancreas, kidney, urinary bladder, colorectum, cervix, and acute myeloid leukemia.…”

Section: Prior Cancer Characteristicsmentioning

confidence: 99%

Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based study

et al. 2021

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Background Cancer survivors are frequently excluded from clinical research, resulting in their omission from the development of many cancer treatment strategies. Quantifying the prevalence of prior cancer in newly diagnosed cancer patients can inform research and clinical practice. This study aimed to describe the prevalence, characteristics, and trends of prior cancer in newly diagnosed cancer patients in Japan. Methods Using Osaka Cancer Registry data, we examined the prevalence, characteristics, and temporal trends of prior cancer in patients who received new diagnoses of lung, stomach, colorectal, female breast, cervical, and corpus uterine cancer between 2004 and 2015. Site-specific prior cancers were examined for a maximum of 15 years before the new cancer was diagnosed. Temporal trends were evaluated using the Cochran-Armitage trend test. Results Among 275,720 newly diagnosed cancer patients, 21,784 (7.9%) had prior cancer. The prevalence of prior cancer ranged from 3.3% (breast cancer) to 11.1% (lung cancer). In both sexes, the age-adjusted prevalence of prior cancer had increased in recent years (P values for trend < 0.001), especially in newly diagnosed lung cancer patients. The proportion of smoking-related prior cancers exceeded 50% in patients with newly diagnosed lung, stomach, colorectal, breast, and cervical cancer. Conclusions The prevalence of prior cancer in newly diagnosed cancer patients is relatively high, and has increased in recent years. Our findings suggest that a deeper understanding of the prevalence and characteristics of prior cancer in cancer patients is needed to promote more inclusive clinical research and support the expansion of treatment options.

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Smoking and subsequent risk of acute myeloid leukaemia: A pooled analysis of 9 cohort studies in Japan

Cited by 13 publications

References 36 publications

Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan

Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan

Epidemiology and Etiology of Leukemia and Lymphoma

Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based study

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