Smoking and the skin

Ortiz, Arisa; Grando, Sergei A.

doi:10.1111/j.1365-4632.2011.05205.x

Cited by 126 publications

(135 citation statements)

References 120 publications

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“…Smoking is well known to be associated with numerous cardiovascular and respiratory diseases as well as different malignancies. In addition, smoking has been associated with skin changes, such as premature aging, wrinkling, loss of elasticity and abnormal wound healing [2,3,4]. The risk of cutaneous squamous cell carcinoma (SCC) is increased among smokers [2,5], and the risk of recurrence of SCC is also increased in smokers and ex-smokers [6].…”

Section: Introductionmentioning

confidence: 99%

“…The risk of cutaneous squamous cell carcinoma (SCC) is increased among smokers [2,5], and the risk of recurrence of SCC is also increased in smokers and ex-smokers [6]. The prevalence of basal cell carcinoma (BCC) of the skin among smokers has been investigated and although the issue remains somewhat unclear [2], there is some proof that smokers are more likely to have higher-risk type of BCC, such as morpheaform BCC, than non-smokers [7]. …”

Section: Introductionmentioning

confidence: 99%

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Increased Numbers of Tryptase-Positive Mast Cells in the Healthy and Sun-Protected Skin of Tobacco Smokers

Kaukinen

Fitzgibbon²,

Oikarinen³

et al. 2014

Dermatology

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Background: Tobacco smoking may cause skin aging through mast cell proteinases. Objective: To compare the numbers of mast cells showing tryptase and chymase in the healthy-looking skin of smokers and non-smokers. Methods: The study subjects consisted of 80 males, 42 of whom were smokers and 38 non-smokers. A skin biopsy from the medial arm was processed for immunohistochemical staining of tryptase and chymase, as well as chymase inhibitors alpha-1-proteinase inhibitor (alpha-1-PI) and alpha-1-antichymotrypsin (alpha-1-AC). Results: The number of tryptase⁺ mast cells was significantly higher in the smoker group (84 ± 32 cells/mm²) than in the non-smoker group (70 ± 32 cells/mm²) (p = 0.044). Likewise, the number of chymase⁺ mast cells was higher in the smoker group (89 ± 20 vs. 80 ± 22 cells/mm²), though statistical significance was not reached (p = 0.07). No significant difference was observed in alpha-1-PI⁺ and alpha-1-AC⁺ cells. Conclusion: Especially tryptase, but probably also chymase, may have an influence on the skin of smokers, such as wrinkling and aging.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increased Numbers of Tryptase-Positive Mast Cells in the Healthy and Sun-Protected Skin of Tobacco Smokers

Kaukinen

Fitzgibbon²,

Oikarinen³

et al. 2014

Dermatology

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“…Smoking not only induces inflammation, but also delays wound healing, partly because it decreases cutaneous blood flow and causes chronic damage to the microcirculation, thus compromising tissue oxygenation. In addition, fibroblast migration into lesional skin is inhibited (13,14). Smoking has been suspected to be a risk factor for skin diseases such as lupus erythematosus (15,16), palmoplantar pustulosis (17,18), psoriasis (19,20), and hidradentis suppurativa (21).…”

mentioning

confidence: 99%

Tobacco smoking and hand eczema – is there an association?

et al. 2015

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SummaryBackground. Numerous risk factors have been suggested for hand eczema. This systematic review evaluates the association between tobacco smoking and hand eczema. Objective. To review the literature systematically on the association between smoking and hand eczema. Methods. The PubMed and EMBASE databases were searched up to 27 January 2015 for articles on the association between tobacco smoking and hand eczema, including human studies in English and German only. Experimental studies, studies on tobacco allergy, case reports, reviews and studies on second-hand smoking were excluded. Results. Twenty articles were included. Among studies in occupational settings, three of seven found a statistically significant positive association between tobacco smoking and hand eczema prevalence rate, as did four of eight population-based studies. The association was stronger for studies in occupational settings than for population-based studies. No studies reported tobacco to be a clear protective factor for hand eczema. Two of five studies regarding severity found a positive association between smoking and hand eczema severity. Conclusion. Overall, the data indicate that smoking may cause an increased frequency of hand eczema, particularly in high-risk occupations. However, data from studies controlling for other risk factors are conflicting, and few prospective studies are available. Studies controlling for other risk factors are needed, and information regarding the diagnosis of subclasses of hand eczema, as well as severity, may be important.

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“…The HHV8 has rarely been present in other vascular neoplasms, such as angiosarcoma, reactive angioendotheliomatosis, and in the lesions of patients, who harbor HHV8, so clinicopathologic correlation is mandatory (7). It has been reported that smoking may interfere in classic presentation of KS, similar to the current patient (8). Nephrectomy in this case was due to abscess formation after complicated renal stone 30 years ago, thus it seems it has not had any association with development of the lesions.…”

Section: Discussionmentioning

confidence: 64%

Multifocal Pyogenic Granuloma-Like Kaposi Sarcoma

et al. 2016

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Background: Kaposi sarcomais a low-grade malignant vascular lesion, which has different histological variants. Pyogenic granuloma-like Kaposi sarcoma is an unusual type of this tumor, which presents as anexophytic small nodule surrounded by an epidermal collaret mimicking pyogenic granuloma yet it has immunohistopathologic features of Kaposi sarcoma. Case Presentation: A 57-year old male with 2 exophytic lesions on the left hand and left foot for 3 months was presented to our center. Both lesions were excised and diagnosis of Kaposi sarcoma was confirmed by histopathology and immunohistochemistry. Human herpesvirus 8 DNA was detected by the polymerase chain reaction in the lesions. Conclusions: Immunostaining methods should be considered in pyogenic granuloma-like lesions with unusual presentation.

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Smoking and the skin

Cited by 126 publications

References 120 publications

Increased Numbers of Tryptase-Positive Mast Cells in the Healthy and Sun-Protected Skin of Tobacco Smokers

Increased Numbers of Tryptase-Positive Mast Cells in the Healthy and Sun-Protected Skin of Tobacco Smokers

Tobacco smoking and hand eczema – is there an association?

Multifocal Pyogenic Granuloma-Like Kaposi Sarcoma

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