Smoking and Time to Clearance of Human Papillomavirus Infection in HIV-Seropositive and HIV-Seronegative Women

Koshiol, Jill; Schroeder, Jennifer R.; Dj, Jamieson; Marshall, Steven W.; Duerr, Ann; Heillig, CM; Kv, Shah; Rs, Klein; Cu‐Uvin, Susan; Schuman, Paula; Celentano, David; Smith, JS

doi:10.1097/00128360-200701000-00026

Cited by 16 publications

(21 citation statements)

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“…Nevertheless, our results are generally consistent with those of other studies showing that cigarette smoking is associated with HPV prevalence (16–19), incidence (22, 23), and persistence (27, 28). Previous studies have shown that cervical mucus of smokers contains measurable amounts of cigarette constituents and their metabolites such as Benzo[ a ]pyrene (35), nicotine, and nicotine derived nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (47).…”

Section: Discussionsupporting

confidence: 93%

“…This lack of dose-response relationship may suggest a low threshold for the effect of smoke on HPV DNA load. Data from this study, with viral load as an outcome, and those from others (22, 23, 27, 28), with outcomes of incident and persistent HPV infections, indicate that cigarette smoking affects the early natural history of HPV infections.…”

Section: Discussionsupporting

confidence: 56%

“…Studies of the impact of cigarette smoking on the early natural history of HPV infections have focused on humoral immune response to HPV (14, 15) and on the prevalence (16–21), incidence (22–26), and persistence of HPV infections (27–33). Most previous studies showed some degree of the association between exposure to cigarette smoke and these measurable events in the natural course of HPV infections, although it might be that women who smoke have sexual behaviors that increase the risk of infection.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Cigarette Smoking and Human Papilloma Virus Types 16 and 18 DNA Load

Koutsky

Castle

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Although cigarette smoking has been associated with increased human papilloma virus (HPV) detection, its impact on HPV DNA load is unknown. Methods: The study subjects were women who were positive for HPV16 and/or HPV18 at enrollment into the Atypical Squamous Cells of Undetermined Significance-Low-grade Squamous Intraepithelial Lesion Triage Study. Assessments of exposure to smoke and sexual behavior were based on self-report. Viral genome copies per nanogram of cellular DNA were measured by multiplex real-time PCR. Linear or logistic regression models were used to assess the relationship between cigarette smoking and baseline viral load. Results: Of the 1,050 women (752 with HPV16, 258 with HPV18, and 40 with both HPV16 and HPV18), 452 (43.0%) were current smokers and 101 (9.6%) were

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

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Relationship Between Cigarette Smoking and Human Papilloma Virus Types 16 and 18 DNA Load

Koutsky

Castle

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Natphopsuk et al [25] found 70.62 % patients had a positive history of smoking. Smoking is documented to be strongly associated with the development of precancerous cervical lesions [42,43].…”

Section: Discussionmentioning

confidence: 99%

Socio-Demographic, Reproductive and Clinical Profile of Women Diagnosed with Advanced Cervical Cancer in a Tertiary Care Institute of Delhi

Dahiya

Bachani

Acharya

et al. 2016

J Obstet Gynecol India

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Introduction Cervical cancer is one of the leading cancers among Indian women with estimated 123,000 new cases and 67,477 deaths in 2012. Cervical cancer is a multietiological disease. Factors such as low socioeconomic status, tobacco use, sexual and reproductive factors, HIV and other sexually transmitted diseases and long-term oral contraceptive use have been suggested as determinants. Assessment of socio-demographic profile and reproductive history gives a better picture of the determinants of cervical carcinoma in low-resource settings. Methods This hospital-based cross-sectional study was undertaken at a tertiary healthcare institute at New Delhi, India. Sixty-seven newly diagnosed women with advanced cervical cancer (stage 2B-4B), who were undertaking radio-and/or chemotherapy, were included to assess their socio-demographic, reproductive and clinical profile. 123Results The mean age of women at the time of detection of cervical cancer was 52.28 ± 11.29 years (range 30-75 years). More than 60 % of patients were illiterate and belonged to middle socioeconomic status. Thirty-nine percentage of the study subjects had their first sexual experience before 15 years of age. Nearly 54 % women had 5 or more pregnancies. Nearly 73 % of women had all deliveries at home. Majority (69 %) of women had symptoms suggestive of reproductive tract infection. Among them, unusual discharge from vagina (73.13 %) followed by bleeding after menopause (55.10 %) and pain in abdomen (44.77 %) were the most common presenting complaints. Pallor was present in nearly two-third (63.93 %) study subjects. More than half (56.72 %) study subjects had moderate anemia, and 7.46 % had severe anemia before treatment. Mean hemoglobin level of the study subjects was 10.35 ± 1.72 gm% before treatment and 9.69 ± 1.29 gm% after treatment. This difference was statistically significant. Around 97 % of the study subjects had squamous cell carcinoma of the cervix. Majority (53.73 %) of the study subjects were in stage 3B of cervical cancer. Combination of radiotherapy and chemotherapy was the most common (77.67 %) modality of treatment.Conclusions and Recommendations Illiteracy, low socioeconomic status, early sexual debut, high fertility, home delivery, reproductive tract infections, use of insanitary clothes during menstruation and anemia were observed in majority of women with advanced cancer cervix. Presence of these factors indicates possible risk of cervical cancer and should be kept in mind when women seek health services. Early diagnosis through high risk or opportunistic screening and timely management of cervical cancer needs to be ensured for better outcomes.

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“…Numerous studies have shown persistence of certain oncogenic HPV types to be a greater risk factor for cervical cancer than HPV presence alone (26,(30)(31)(32)(33) and that different HPV types have varying propensities for persistence (34,35). The effect of smoking on persistence of oncogenic HPV infections has been difficult to discern due to contradictory findings (15,(36)(37)(38)(39)(40)(41)(42). Most likely, this is due to differences in definitions for persistence, HPV type, study design, and sample sizes.…”

Section: Discussionmentioning

confidence: 99%

Synergy between Cigarette Smoking and Human Papillomavirus Type 16 in Cervical Cancer In situ Development

Gunnell

Tran

Torrång

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: A majority of studies have implicated the involvement of cigarette smoking in cervical cancer development, although its mechanism of action remains unclear. We conducted a large population-based case-control study to address the potential interaction between smoking and human papillomavirus type 16 (HPV-16) in development of cervical cancer in situ (CIS). Methods: Information on risk factors for CIS was collected via interview, and archival cervical smears were tested for HPV-16 DNA presence in cases (n = 375) and controls (n = 363). Adjusted odds ratios (OR) for the effects of smoking, HPV-16 presence/absence, and load at first smear (taken, on average, 9 years before diagnosis) were calculated. Results: The risk for CIS among current smokers who were HPV-16 positive at time of first smear was >14-fold [adjusted OR, 14.4; confidence interval (95% CI), 5.6-36.8] compared

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Smoking and Time to Clearance of Human Papillomavirus Infection in HIV-Seropositive and HIV-Seronegative Women

Cited by 16 publications

References 0 publications

Relationship Between Cigarette Smoking and Human Papilloma Virus Types 16 and 18 DNA Load

Relationship Between Cigarette Smoking and Human Papilloma Virus Types 16 and 18 DNA Load

Socio-Demographic, Reproductive and Clinical Profile of Women Diagnosed with Advanced Cervical Cancer in a Tertiary Care Institute of Delhi

Synergy between Cigarette Smoking and Human Papillomavirus Type 16 in Cervical Cancer In situ Development

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