Background
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. Several observational studies showed sex-related and region-based differences in epidemiology, underlying causes, and therapeutic outcomes of HF, highlighting the need for a better understanding of the underlying mechanisms and potential strategies to address these disparities to decrease the burden of HF.
Methods and Results
Global and regional estimates of HF prevalence and YLDs by age, year, gender, and world region were based on data from the Global Burden of Disease Study 2019(GBD 2019). Globally, the prevalence number of HF increased significantly from 27.2 million to 56.2 million, increased by 106.6% from 1990. A similar trend could be found in HF-related YLDs number. An intersection could be found in the curves of different genders around age 75, after which women showed a heavier HF-related burden compared to men. The leading three causes of YLDs due to HF in 2019 were ischemic heart disease (IHD, 37.2%), hypertension heart disease (HHD, 33.1%) and chronic obstructive pulmonary disease (COPD, 9.1%). Estimated by age-standardized prevalence rate, although alcoholic cardiomyopathy accounted for < 0.5% in South Asia (ranked 11), and Southern Sub-Saharan Africa (ranked 15), but in Eastern Europe was 8.9% (ranked 3). Although chagas disease was a major cause of HF in Latin America (ranked 4), while in other GBD regions, the impact was almost zero. An increasingly upward trend could be found in all SDI groups by year, especially in high-middle and middle countries. After age-standardized, HF-related burden in high SDI region has decreased by 17.1% since 1990, while in other SDI groups showed a slight increase or stable trend. The age-standardized YLDs rate were negatively correlated with SDI in pulmonary disease induced HF but positively correlated with SDI in cardiovascular disease induced HF.
Conclusion and Interpretation:
Our study have shown that men have a higher prevalence and worse prognosis of HF compared to women, and women tend to develop HF at an older age. The underlying causes of HF varied significantly in different age groups, geographical and socioeconomic regions. Targeted considerations and specific strategies are needed to address these disparities to enhance heart health and decrease the burden of HF. Future research should focus on underlying mechanisms and potential strategies in sex-related differences to guide gender-based treatment of HF.