Smoking Cessation and Subsequent Weight Change

Robertson, Lindsay; McGee, Rob; Hancox, Robert J.

doi:10.1093/ntr/ntt284

Cited by 16 publications

(8 citation statements)

References 21 publications

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“…Interestingly, we showed that smoking cessation after diagnosis was strongly associated with weight gain. This phenomenon is well described in the general population [ 44 , 45 ], but is of particular importance in cancer patients, who are strongly advised to stop smoking after diagnosis. Patients who were smoking after cancer diagnosis were also at higher risk of weight gain compared to never smoker consistent with another study [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Sociodemographic and economic factors are associated with weight gain between before and after cancer diagnosis: results from the prospective population-based NutriNet-Santé cohort

Fassier

Zelek

Bachmann³

et al. 2017

Oncotarget

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PurposeWhile many cancer patients are affected by weight loss, others tend to gain weight, which may impact prognosis and risk of recurrence and of second cancer. The aim of this prospective study was to investigate weight variation between before and after cancer diagnosis and socio-demographic, economic, lifestyle and clinical factors associated with moderate-to-severe weight gain.Methods1051 incident cases of first primary cancer were diagnosed in the NutriNet-Santé cohort between 2009 and 2015. Weight was prospectively collected every 6 months since subjects’ inclusion (i.e. an average of 2y before diagnosis). Mean weights before and after cancer diagnosis were compared with paired Student's t-test. Factors associated with moderate-to-severe weight gain (≥5% of initial weight) were investigated by age and sex-adjusted logistic regression.ResultsWeight loss was observed in men (-3.54±4.39kg in those who lost weight, p=0.0002) and in colorectal cancer patients (-3.94±4.40kg, p=0.001). Weight gain was observed in breast and skin cancers (2.83±3.21kg, p=0.04, and 2.96±2.75kg, p=0.04 respectively). Women (OR=1.75[1.06-2.87],p=0.03), younger patients (2.44[1.51-3.70],p<0.0001), those with lower income (OR=1.30[1.01-1.72],p-trend=0.007), lower education (OR=1.32[1.03-2.70],p-trend=0.03), excess weight before diagnosis (OR=1.64[1.12-2.42],p=0.01), lower physical activity (OR=1.28[1.01-1.64],p=0.04) and those who stopped smoking (OR=4.31[1.99-9.35],p=0.005]) were more likely to gain weight. In breast cancer patients, induced menopause was associated with weight gain (OR=4.12[1.76-9.67]), but no association was detected for tumor characteristics or treatments.ConclusionThis large prospective cohort provided original results on weight variation between before and after cancer diagnosis, highlighting different weight trajectories. Socio-demographic and economic factors appeared to influence the risk of weight gain, illustrating social inequalities in health.

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Section: Discussionmentioning

confidence: 99%

Sociodemographic and economic factors are associated with weight gain between before and after cancer diagnosis: results from the prospective population-based NutriNet-Santé cohort

Fassier

Zelek

Bachmann³

et al. 2017

Oncotarget

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“…Sensitivity analyses repeated the analyses among non-tobacco smokers and current tobacco smokers separately. Because both tobacco and cannabis smoking habits may influence body weight [26, 27], which may in turn influence respiratory symptoms [28], additional sensitivity analyses included BMI in the models and excluded pregnant women.…”

Section: Methodsmentioning

confidence: 99%

Effects of quitting cannabis on respiratory symptoms

et al. 2015

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Smoking cannabis is associated with symptoms of bronchitis. Little is known about the persistence of symptoms after stopping cannabis use. We assessed associations between changes in cannabis use and respiratory symptoms in a population-based cohort of 1037 young adults. Participants were asked about cannabis and tobacco use at ages 18, 21, 26, 32 and 38 years. Symptoms of morning cough, sputum production, wheeze, dyspnoea on exertion and asthma diagnoses were ascertained at the same ages. Frequent cannabis use was defined as ≥52 occasions over the previous year. Associations between frequent cannabis use and respiratory symptoms were analysed using generalised estimating equations with adjustments for tobacco smoking, asthma, sex and age. Frequent cannabis use was associated with morning cough (OR 1.97, p<0.001), sputum production (OR 2.31, p<0.001) and wheeze (OR 1.55, p<0.001). Reducing or quitting cannabis use was associated with reductions in the prevalence of cough, sputum and wheeze to levels similar to nonusers. Frequent cannabis use is associated with symptoms of bronchitis in young adults. Reducing cannabis use often leads to a resolution of these symptoms.

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“…18 Weekly binge alcohol drinking at age 21 was assessed via self-report of annual frequency of consuming five or more drinks on a single occasion. 21 …”

Section: Other Variablesmentioning

confidence: 99%