Smoking cessation increases levels of osteocalcin and uncarboxylated osteocalcin in human sera

Kiyota, Yasuhiro; Muramatsu, Hiroyasu; Sato, Yuiko; Kobayashi, Tami; Miyamoto, Kana; Iwamoto, Takuji; Matsumoto, Morio; Nakamura, Masaya; Tateno, Hiroki; Sato, Kazuki; Miyamoto, Takeshi

doi:10.1038/s41598-020-73789-4

Cited by 12 publications

(11 citation statements)

References 23 publications

(30 reference statements)

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“…Alcohol is metabolized to acetaldehyde, which inhibits osteoblasts. 19 However, despite there being a significant difference in the proportion of alcohol drinkers in the fracture group than in the non-fracture group in univariate analysis, this was not significant in multivariate analysis. This could be because we did not measure the amount of alcohol consumed.…”

Section: Discussionmentioning

confidence: 85%

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Risk Factors for New Vertebral Fracture After Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures

Zhang¹,

Yang²,

Hao³

et al. 2021

CIA

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Purpose To analyze the risk factors for new vertebral fractures after percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCFs). Patients and Methods We retrospectively reviewed the records of patients with symptomatic OVCFs who underwent PVP in our hospital, from January 2014 to January 2019. Demographic and lifestyle data on the presence of underlying chronic disease, preoperative bone mineral density, details of vertebral fractures, postoperative osteoporosis treatment, and new fracture development were collected. Patients were divided into postoperative fracture and non-fracture groups. To identify the independent risk factors for new vertebral fracture development, variables significant on univariate analysis were included in a multivariate regression model. Results Of the 2202 patients treated with PVP, 362 (16.43%) had a new postoperative vertebral fracture. All patients were followed up for >12 months (mean 14.7 months). Univariate analysis revealed no significant difference in height; body weight; preoperative bone mineral density; number of fractured vertebrae; injection volume of bone cement in a single vertebra; leakage rate of bone cement; or presence of hypertension, coronary heart disease, and chronic obstructive pulmonary disease between the fracture and non-fracture groups (P>0.05). Age, sex, smoking, alcohol consumption, diabetes mellitus, postoperative exercise, and postoperative osteoporosis treatment were associated with new vertebral fractures (all P<0.05). A multivariate analysis showed that age (odds ratio [OR]=1.212, P<0.0001), female sex (OR=1.917, P<0.0001), smoking (OR=1.538, P=0.026), and diabetes (OR=1.915, P<0.0001) were positively correlated with new vertebral fracture development, whereas postoperative exercise (OR=0.220, P<0.0001) and osteoporosis treatment (OR=0.413, P<0.0001) were negatively correlated. Conclusion Elderly patients, females, and those with a history of smoking and diabetes are at high risk of new vertebral fracture after PVP. Patients should be encouraged to stop smoking and consuming alcohol, control blood glucose level, participate in sufficient physical activity, and adhere to osteoporosis treatment to prevent new vertebral fractures.

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Section: Discussionmentioning

confidence: 85%

“…Therefore, if a patient’s family member is a smoker, they too should be advised to stop smoking. Kiyota et al 19 confirmed that the disruption of bone homeostasis induced by smoking could recover gradually after smoking cessation. Therefore, stopping smoking postoperatively will help prevent the occurrence of new fractures.…”

Section: Discussionmentioning

confidence: 95%

Risk Factors for New Vertebral Fracture After Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures

Zhang¹,

Yang²,

Hao³

et al. 2021

CIA

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“…We investigated the influence of tobacco smoking and alcohol consumption on the development of osteoporosis by analyzing the data collected by the TWB because these influences were unclear in previous research [23][24][25][26] . First, we found the participants in the smokingonly group and both smoking and drinking group to be at a higher risk of developing osteoporosis than those in the non-smoking and non-drinking groups.…”

Section: Discussionmentioning

confidence: 99%

Effects of sex, tobacco smoking, and alcohol consumption osteoporosis development: Evidence from Taiwan biobank participants

Yang¹,

Lai²,

Huang³

et al. 2021

Tob. Induc. Dis.

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Osteoporosis is an important risk factor affecting public health. Osteoporosis begins without major discomfort but leads to age-related fractures later in life 1 . Osteoporosis is a reduction in bone mineral density (BMD). Usually, it is asymptomatic and is therefore undetected until a fracture 2 . In people with osteoporosis, their bone tissue is qualitatively ABSTRACT INTRODUCTION Osteoporosis is major public health concern, but the long-term impacts of tobacco and alcohol consumption on its development are unclear. This study analyzed the relationship between tobacco and alcohol use and osteoporosis by using data from the Taiwan Biobank (TWB), established in 2012. METHODS Participants in TWB were included in our study, with a total of 18394 respondents included for analysis. To investigate the relationship between tobacco and alcohol use and osteoporosis, we surveyed their bone mineral density (BMD), consumption of tobacco and alcohol and other covariate data. RESULTS We found that participants in the tobacco smoking only group (OR=1.24; 95% CI: 1.08-1.42, p=0.003) and the group that both smoked and consumed alcohol (OR=1.39; 95% CI: 1.09-1.77, p=0.008) were more likely to develop osteoporosis than were participants who neither drank alcohol nor smoked. Menopause is strongly associated with osteoporosis in women, and we found that women who used alcohol or tobacco were not at a significantly higher risk than those in the reference group (tobacco only, OR=1.15; 95% CI: 0.86-1.53, p=0.345; both tobacco and alcohol, OR=0.61; 95% CI: 0.14-2.60, p=0.5040). However, men in these groups were at a significantly higher risk than the reference group (tobacco only, OR=1.26; 95% CI: 1.07-1.48, p=0.006; both tobacco and alcohol, OR=1.32; 95% CI: 1.03-1.70, p=0.030). Menopause was a significant risk factor for osteoporosis (OR=2.46; 95% CI: 1.77-3.41, p<0.001). CONCLUSIONS The influence of tobacco use on osteoporosis was significant, particularly in men, but the effects of alcohol consumption were equivocal in our study. The interactions between tobacco use, alcohol use, and menopausal status on osteoporosis should be considered in future studies.

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“…In postmenopausal women, bone mineral density was significantly lower in smokers than in non-smokers in a human clinical study. An additional animal study showed that administration of nicotine to wild-type mice decreased bone mass ( Kiyota et al, 2020 ).…”

Section: Non-communicable Diseases Caused By Smoking: Dysregulation O...mentioning

confidence: 99%

“…Also, chronic overstimulation of the RAAS is thought to result in lower vitamin D levels ( Ferder et al, 2013 ). Smoking cessation was associated with a significant increase in bone mineral density within a short period of time in a human clinical trial and in an animal study, as reflected by a significant decrease in serum levels of TRAP5b, a marker of bone resorption, and an increase in levels of osteocalcin and non-carboxylated osteocalcin ( Kiyota et al, 2020 ).…”

Section: Non-communicable Diseases Caused By Smoking: Dysregulation O...mentioning

confidence: 99%

Pathogenesis of (smoking-related) non-communicable diseases—Evidence for a common underlying pathophysiological pattern

Köpp¹

2022

Front. Physiol.

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Non-communicable diseases, like diabetes, cardiovascular diseases, cancer, stroke, chronic obstructive pulmonary disease, osteoporosis, arthritis, Alzheimer’s disease and other more are a leading cause of death in almost all countries. Lifestyle factors, especially poor diet and tobacco consumption, are considered to be the most important influencing factors in the development of these diseases. The Western diet has been shown to cause a significant distortion of normal physiology, characterized by dysregulation of the sympathetic nervous system, renin-angiotensin aldosterone system, and immune system, as well as disruption of physiological insulin and oxidant/antioxidant homeostasis, all of which play critical roles in the development of these diseases. This paper addresses the question of whether the development of smoking-related non-communicable diseases follows the same pathophysiological pattern. The evidence presented shows that exposure to cigarette smoke and/or nicotine causes the same complex dysregulation of physiology as described above, it further shows that the factors involved are strongly interrelated, and that all of these factors play a key role in the development of a broad spectrum of smoking-related diseases. Since not all smokers develop one or more of these diseases, it is proposed that this disruption of normal physiological balance represents a kind of pathogenetic “basic toolkit” for the potential development of a range of non-communicable diseases, and that the decision of whether and what disease will develop in an individual is determined by other, individual factors (“determinants”), such as the genome, epigenome, exposome, microbiome, and others. The common pathophysiological pattern underlying these diseases may provide an explanation for the often poorly understood links between non-communicable diseases and disease comorbidities. The proposed pathophysiological process offers new insights into the development of non-communicable diseases and may influence the direction of future research in both prevention and therapy.

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Smoking cessation increases levels of osteocalcin and uncarboxylated osteocalcin in human sera

Cited by 12 publications

References 23 publications

Risk Factors for New Vertebral Fracture After Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures

Risk Factors for New Vertebral Fracture After Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures

Effects of sex, tobacco smoking, and alcohol consumption osteoporosis development: Evidence from Taiwan biobank participants

Pathogenesis of (smoking-related) non-communicable diseases—Evidence for a common underlying pathophysiological pattern

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