Smoking cessation is associated with decreased mortality and improved amputation-free survival among patients with symptomatic peripheral artery disease

Armstrong, Ehrin J.; Wu, Julie; Singh, Gagan D.; Dawson, David L.; Pevec, William C.; Amsterdam, Ezra A.; Laird, John R.

doi:10.1016/j.jvs.2014.08.064

Cited by 165 publications

(107 citation statements)

References 23 publications

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“…[164][165][166] Interestingly, cigarette smoking may also increase the risk of diabetes mellitus. In the Physician's Health Study, smoking increased the risk 2-fold, and there was a dose response to pack-years smoked.…”

Section: Smoking Cessationmentioning

confidence: 99%

Vascular Complications of Diabetes

Beckman

Creager

2016

Circulation Research

302

218

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Over the last several decades, the global incidence and prevalence of diabetes mellitus has increased significantly. The raised incidence rate is projected to continue as greater numbers of persons adopt a Western lifestyle and diet. Patients with diabetes mellitus are at heightened risk of both adverse microvascular and cardiovascular events. Moreover, once cardiovascular disease develops, diabetes mellitus exacerbates progression and worsens outcomes. The medical management of patients with diabetes mellitus mandates comprehensive risk factor modification and antiplatelet therapy. Recent clinical trials of new medical therapies continue to inform the care of patients with diabetes mellitus to reduce both cardiovascular morbidity and mortality.

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Section: Smoking Cessationmentioning

confidence: 99%

Vascular Complications of Diabetes

Beckman

Creager

2016

Circulation Research

302

218

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“…A general approach to the treatment of peripheral artery disease lower extremity angiography, subsequent smoking cessation was associated with lower rates of all-cause mortality (absolute event rate of 14 vs 31 %; HR 0.40; 95 % CI 0.18-0.90) and improved amputation-free survival (absolute event free rate of 81 vs 60 %; HR 0.43; 95 % CI 0.22-0.86) compared to patients who continued to smoke [20]. Current guidelines recommend smoking cessation for all patients with PAD [13].…”

Section: Figmentioning

confidence: 94%

Medical Therapy in Peripheral Artery Disease and Critical Limb Ischemia

Foley

Waldo

Armstrong

2016

Curr Treat Options Cardio Med

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Peripheral artery disease (PAD) comprises atherosclerosis of the aorta and lower extremities. Many patients with PAD are asymptomatic, while others present with intermittent claudication (IC) or critical limb ischemia (CLI). Defined as rest pain or tissue loss that persists for >2 weeks, CLI represents the most severe clinical manifestation of PAD and is associated with an increased risk of limb loss and death. Patients with PAD, including those with CLI, are underdiagnosed and undertreated. In addition to smoking cessation, medical therapy with an antiplatelet agent and statin is recommended for all patients with PAD. Regular exercise has been shown to improve walking distance and quality of life in patients with symptomatic PAD and should be incorporated into each patient's treatment plan. In patients who have CLI and in those with persistent lifestyle-limiting claudication despite optimal medical therapy and an exercise program, revascularization is indicated for limb salvage and symptom relief, respectively. Consensus guidelines currently support an endovascular first approach to revascularization in the majority of cases. Surgical procedures provide an alternative to endovascular therapy in select cases.

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“…Tobacco cessation has been shown to lower 5-year mortality and improve amputation-free survival [56]. Cessation should be encouraged at every office visit.…”

Section: Treatmentmentioning

confidence: 99%

Screening and Basic Workup of a Patient with Peripheral Vascular Disease – A Primer of Physicians

Se¹,

Placido²,

Patel³

et al. 2017

Journal of Clinical and Experimental Research in Cardiology

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Peripheral vascular disease (PVD) is a prevalent condition associated with significant morbidity and mortality in a variety of patient populations. When not properly recognized and treated, it can result in complications that include myocardial infarction, ischemic stroke, and cardiovascular death. In this review, we describe the risk factors, clinical presentation, diagnostic evaluation, treatment, and alternative diagnoses that can confound the diagnosis of PVD.

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Smoking cessation is associated with decreased mortality and improved amputation-free survival among patients with symptomatic peripheral artery disease

Abstract: Approximately one-third of active smokers with peripheral artery disease successfully quit smoking ≤ 1 year after lower extremity angiography. Patients who quit smoking have lower mortality and improved amputation-free survival compared with patients who continue smoking.

Cited by 165 publications

References 23 publications

Vascular Complications of Diabetes

Vascular Complications of Diabetes

Medical Therapy in Peripheral Artery Disease and Critical Limb Ischemia

Screening and Basic Workup of a Patient with Peripheral Vascular Disease – A Primer of Physicians

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