Smoking cessation is associated with increased plasma adiponectin levels in men

Otsuka, Fumiyuki; Kojima, Sunao; Maruyoshi, Hidetomo; Kojima, Sachi; Matsuzawa, Yasushi; Funahashi, Tohru; Kaikita, Koichi; Sugiyama, Seigo; Kimura, Kazuo; Umemura, Satoshi; Ogawa, Hisao

doi:10.1016/j.jjcc.2008.11.004

Cited by 32 publications

(48 citation statements)

References 30 publications

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“…Furthermore, the mRNA expression level of AdipoR2 was lower in cases with smoker's bronchiolitis and cases of squamous cell carcinoma than in cases without smoking history and cases of adenocarcinoma, respectively. These findings suggest that smoking may reduce the tissue expression of adiponectin receptors, particularly AdipoR1 in NSCLC, in addition to its effects on reducing plasma levels of adiponectin (Takefuji et al 2007;Otsuka et al 2009;Kawamoto et al 2010).…”

Section: Discussionmentioning

confidence: 88%

“…Serum levels of adiponectin have been found to have an inverse correlation with smoking (Abbasi et al 2006;Takefuji et al 2007;Otsuka et al 2009;Sull et al 2009;Kawamoto et al 2010). We therefore assessed whether expression of adiponectin receptors was associated with the smoking status of the patients.…”

Section: Discussionmentioning

confidence: 99%

“…Smokers have a lower plasma level of adiponectin than non-smokers (Takefuji et al 2007;Otsuka et al 2009;Sull et al 2009;Kawamoto et al 2010). It is not yet clear whether the lower plasma level of adiponectin in lung cancers is a result of smoking or due to the coexistence of insulin resistance and lung cancer.…”

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confidence: 99%

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Expression of Adiponectin Receptor 1 Is Indicative of Favorable Prognosis in Non-small Cell Lung Carcinoma

Abdul‐Ghafar

Park

et al. 2013

Tohoku J. Exp. Med.

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Lung cancer is a major cause of cancer-related death worldwide. It is believed that obesity-related malignancies such as breast, endometrial, colorectal, and kidney carcinomas have lower plasma level and/ or tissue expression of adiponectin receptors. However, the association between adiponectin receptors and lung cancer, a non obesity-related malignancy, is still unknown. We evaluated the tissue expression of adiponectin receptor (AdipoR) 1 and AdipoR2 in 83 cases of non-small cell lung carcinoma (NSCLC) and matched non-neoplastic lung tissues by immunohistochemistry and real-time polymerase chain reaction (PCR). Clinicopathological data, including smoking history, smoker's bronchiolitis, emphysema, lymph node metastasis, and T-stage were collected and evaluated. Expression of immunohistochemically stained AdipoR1 and AdipoR2 was observed in all samples of non-neoplastic lung tissues. Both receptors showed higher mRNA expression in non-neoplastic than neoplastic tissues ( p < 0.05). In NSCLC tissues, AdipoR1 immunohistochemical expression was not observed in most of patients with squamous cell carcinoma and current smoking history (31/42, p = 0.04 and 25/29, p = 0.003, respectively). Additionally, AdipoR1 mRNA expression was significantly lower in patients with lymph node metastasis ( p = 0.05). Meanwhile, AdipoR2 immunohistochemical stain expression was inversely correlated with T-stage ( p = 0.05) and AdipoR2 mRNA expression was significantly lower in patients with smoker's bronchiolitis ( p = 0.01) and emphysema ( p = 0.03). Patients with expression of AdipoR1 had longer overall survival. AdipoR2 expression was not correlated with patients' survival. In conclusion, we suggest that expression of AdipoR1 is indicative of favorable prognosis and may be used as prognostic marker in NSCLC.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Expression of Adiponectin Receptor 1 Is Indicative of Favorable Prognosis in Non-small Cell Lung Carcinoma

Abdul‐Ghafar

Park

et al. 2013

Tohoku J. Exp. Med.

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“…A cross-sectional design was applied in 9 studies 14,[17][18][19][20][21][22][23][24] , and an intervention design was used in the other 2 studies 15,16) . The intervention studies used the following treatment: a 9-week pharmacological approach (150 mg sustained-release bupropion twice daily) for non-specific subjects 15) and a 6-month nonpharmacological approach to quit smoking for patients with stable angina pectoris 16) .…”

Section: Study Designsmentioning

confidence: 99%

“…The intervention studies used the following treatment: a 9-week pharmacological approach (150 mg sustained-release bupropion twice daily) for non-specific subjects 15) and a 6-month nonpharmacological approach to quit smoking for patients with stable angina pectoris 16) . While most of the cross-sectional studies were conducted in healthy and non-specific diseased populations recruited from general health check-ups or advertisements for the study participation 14,[17][18][19][20][22][23][24] , only one study focused on patients with coronary artery disease 21) .…”

Section: Study Designsmentioning

confidence: 99%

Adiponectin and Smoking Status: A Systematic Review

Kotani

Hazama

Hagimoto

et al. 2012

J Atheroscler Thromb

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Aim:Smoking and adiponectin are individually associated with cardiometabolic pathologies. The present systematic review was carried out in order to summarize the association between the smoking status and circulating adiponectin levels. Methods: Original articles, restricted to epidemiological studies (by a cross-sectional, case-control and cohort study design) and intervention studies for adult humans, were screened for the years 1995-2010. All of the research group members then selected the eligible literature and assessed the articles in a structured systematic review manner. Results: There were 11 key studies, which included 9 articles with a cross-sectional design and 2 articles with an intervention design. Most cross-sectional studies reported lower levels of adiponectin in current smokers than in non/never smokers and/or ex-smokers, while 2 studies reported a non-significant difference in adiponectin between male smokers and non-smokers. The two intervention studies, conducted in patients on 9-week bupropion treatment and 6-month non-pharmacological treatment, reported that smoking cessation increased the adiponectin levels. Conclusion: This review suggests that there is a decreased adiponectin level in current smokers and this reduction can be reversed by quitting smoking. More studies are required to confirm the findings and elucidate the biological mechanisms underlying the association between the smoking status and adiponectin levels.

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Adiponectin, hemoglobin, and cardiovascular risk in an indigenous siberian population

Streeter

Squires

Leonard

et al. 2015

American J Hum Biol

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Smoking cessation is associated with increased plasma adiponectin levels in men

Abstract: Smoking cessation is associated with increased plasma adiponectin levels in men with stable angina, suggesting that the significance of smoking cessation may be partly explained by the increase in adiponectin level.

Cited by 32 publications

References 30 publications

Expression of Adiponectin Receptor 1 Is Indicative of Favorable Prognosis in Non-small Cell Lung Carcinoma

Expression of Adiponectin Receptor 1 Is Indicative of Favorable Prognosis in Non-small Cell Lung Carcinoma

Adiponectin and Smoking Status: A Systematic Review

Adiponectin, hemoglobin, and cardiovascular risk in an indigenous siberian population

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