Abstract:Cigarette smoking is a risk factor for developing osteoporosis, and previous studies suggest lymphocytes are required for normal bone homeostasis and peak bone mass. We hypothesized that lymphocyte development is adversely affected by smoke exposure. If so, this outcome would provide a mechanism to partly explain how cigarette smoking promotes osteoporosis. To test this possibility, we investigated how the duration and cessation of cigarette smoke exposure affected the development, distribution, and function o… Show more
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