Smoking habit and genetic factors associated with lung cancer in a population highly exposed to arsenic

Adonis, Marta; Martínez, Victor D.; Marı́n, Pedro; Berrios, Daniela; Gil, Lionel

doi:10.1016/j.toxlet.2005.04.007

Cited by 19 publications

(14 citation statements)

References 22 publications

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“…Carriers of CYP1A1*2A/GSTM1 homozygous deletion genotype show increased odds ratios for lung cancer, especially among smokers [71, 72]. In addition, our group has recently proposed that genomic aberrations in arsenic induced lung cancers exhibit distinct molecular characteristics.…”

Section: Common Arsenic-induced Malignanciesmentioning

confidence: 99%

Arsenic Exposure and the Induction of Human Cancers

Martínez

Vucic

Becker‐Santos

et al. 2011

Journal of Toxicology

355

209

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Arsenic is a metalloid, that is, considered to be a human carcinogen. Millions of individuals worldwide are chronically exposed through drinking water, with consequences ranging from acute toxicities to development of malignancies, such as skin and lung cancer. Despite well-known arsenic-related health effects, the molecular mechanisms involved are not fully understood; however, the arsenic biotransformation process, which includes methylation changes, is thought to play a key role. This paper explores the relationship of arsenic exposure with cancer development and summarizes current knowledge of the potential mechanisms that may contribute to the neoplastic processes observed in arsenic exposed human populations.

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Section: Common Arsenic-induced Malignanciesmentioning

confidence: 99%

Arsenic Exposure and the Induction of Human Cancers

Martínez

Vucic

Becker‐Santos

et al. 2011

Journal of Toxicology

355

209

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“…Furthermore, for DR70, serum was separated and tested along with the calibrators according to AMDL Diagnostics Onko Sure protocol (Radient Pharmaceuticals) as described in Adonis et al [19] and Hatton et al [38]. The best cutoff values for the DR70 immunoassay was obtained with the ROC curve analysis using the MedCalc statistical software 12.1 with 95% confidence intervals.…”

Section: Methodsmentioning

confidence: 99%

“…High levels of BaP and individual host susceptibility might determine a high levels of diolepoxide (BPDE)-DNA adduct. It has been postulated that natural compounds like arsenic (As), enhance the BPDE-DNA adduct induced mutagenesis, suggesting that As might act as a co-mutagen to promote the development of human LC [19–21]. …”

Section: Introductionmentioning

confidence: 99%

“…This work has been done in Antofagasta and Metropolitan regions in order to evaluate two biomarkers AQC and DR70 (Onko Sure) as tools in detection of LC and detection of pre-neoplastic lesions related with LC. Previously, the researchers of this work used the biomarker DR70, as screening tool of LC in advance stages but not in pre neoplastic lesions, in a population exposed historically to As in drinking water, showing that this biomarker might provide relevant information to identify individuals with a lung cancer [19, 20]. Additionally, the researchers have been working with sputum specimen in order to study genomic alterations in a Chilean population with high risk of LC (manuscript in preparation).…”

Section: Introductionmentioning

confidence: 99%

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Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population

et al. 2014

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BackgroundThe mortality of lung cancer (LC), increases each year in the world, in spite of any advances, in development of new drugs to advance stages of LC. The high incidence of LC has been associated with smoking habit, genetic diversity and environmental pollution. Antofagasta region has been reported to have the highest LC mortality rate in Chile and its inhabitants were exposed to arsenic in their drinking water in concentrations as high as 870 μg/L. Non-invasive techniques such as biomarkers (Automatic Quantitative Cytometry: AQC and DR70) and Auto Fluorescence Bronchoscopy (AFB) might be potentially useful as a supplementary diagnostic approach and early detection. Early detection is one of the most important factors to intervene and prevent cancer progression in LC. This is a work of an ongoing prospective bimodality cancer surveillance study in high risk LC volunteers. Enrolment was done in subjects from Antofagasta and Metropolitan regions. In addition, we enrolled subjects who were suspected of having lung cancer. AQC, DR70 and AFB were used as tools in the detection of pre-neoplastic (PNL) and neoplastic lesions (NL).ResultsHalf of the samples, classified as suspicious by AFB, were confirmed as metaplasia or dysplasia by histopathology. For LC, DR70 showed a higher sensitivity (95.8%) and specificity (91.9%) than AQC. However, for PNL AQC showed a higher sensitivity (91.9%) than DR70 (27.3%), although both with low PPV values. As a pre screener, both biomarkers might be employed as complementary tools to detect LC, especially as serially combined tests, with a sensitivity of 60% and a PPV of 65.2%. Additionally, the use of parallel combined tests might support the detection of PNL (sensitivity 91.2%; PPV 49.1%).ConclusionThis work adds information on cellular and molecular biomarkers to complement imaging techniques for early detection of LC in Latin America that might contribute to formulate policies concerning screening of LC. Supported by INNOVA-CORFO, Chile.

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“…In the same period, the Antofagasta region (North of Chile), historically exposed to high levels of drinking water Arsenic (dw-As), showed a mortality rate of 31.6 for both genders, with a rate of 44.2 and 17.4, for men and women, respectively [4][5][6][7][8]. The implementation of earlydetection technologies and prognostic biomarkers are imperative, specifically in cities highly exposed to environmental carcinogens, such as PAHs and Arsenic [9][10][11][12][13]. It is extremely important to have complementary and noninvasive tools, to apply in asymptomatic population, especially to individuals with high risk of LC.…”

Section: Introductionmentioning

confidence: 99%

Circulating Free DNA in Serum and Genomic Alterations of Lung Cancer Patients and High Risk Individuals Exposed to Environmental Pollution

Marta¹,

T²,

Ulises³

et al. 2017

Biomark J

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The implementation of early-detection technologies and prognostic biomarkers are imperative, specifically in cities highly exposed to environmental carcinogens, such as PAHs and Arsenic. This study proposed to evaluate cfDNA levels and determine CNAs in serum cfDNA in LC and PNL patients. The study enrolled a total of 107 people, from the Metropolitan (N=51) and Antofagasta (N=56) regions, with medium or high LC risk. The cfDNA was isolated from serum aliquots using Qiagen QIAamp DNA mini kit. HMMs analysis in cfDNA, was used as a probabilistic model to determine an unknown sequence and defined Minimal Common Regions (MCRs) of recurring DNA gains and losses. This study shows that cfDNA levels increased during malignancy of LC but not significantly during premalignant lesions or pre-invasive stages. The cfDNA could be used as a complementary tool to prognosis and evolution of LC, with high precision (specificity of 87.3% and PNV of 76.4%). Additionally, the cfDNA carry some chromosomal aberrations related with the lung tumorigenesis process that could be used to confirm a suspected case of LC. Within these alterations our results suggest the loss of specific chromosomic fragments, contain genes related with inflammation response (SERPING1), humoral immune response (IGCK), innate immunity and epithelial integrity (CTNN1), tumor suppressor (MAP2K4, DMTF1 and ABCB4), and response to oxidative stress (COX10). In conclusion, these biomarkers in cfDNA, could have a great potential as screening methods in population with high risk for LC.

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Smoking habit and genetic factors associated with lung cancer in a population highly exposed to arsenic

Cited by 19 publications

References 22 publications

Arsenic Exposure and the Induction of Human Cancers

Arsenic Exposure and the Induction of Human Cancers

Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population

Circulating Free DNA in Serum and Genomic Alterations of Lung Cancer Patients and High Risk Individuals Exposed to Environmental Pollution

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