Smoking history and severe atrophic gastritis assessed by pepsinogen are risk factors for the prevalence of synchronous gastric cancers in patients with gastric endoscopic submucosal dissection: a multicenter prospective cohort study

Hatta, Waku; Koike, Tomoyuki; Asonuma, Sho; Okata, Hideki; Uno, Kaname; Oikawa, Takuya; Iwai, Wataru; Yonechi, Makoto; Fukushi, Daisuke; Kayaba, Shoichi; Kikuchi, Ryosuke; Ohyauchi, Motoki; Fushiya, Jun; Maejima, Ryuhei; Abe, Yasuhiko; Kawamura, Masashi; Honda, Junya; Kondo, Yutaka; Dairaku, Naohiro; Norita, Kazuaki; Watanabe, Kenta; Takahashi, K.; Echigo, Hiroharu; Abe, Yuina; Endo, Hiroyuki; Okata, Tomoki; Hoshi, Tatsuya; Nakamura, Tomohiro; Nakaya, Naoki; Iijima, Katsunori; Masamune, Atsushi; Satō, Isao; Ono, Yoshitaka; Abe, Hiroko; Ogata, Yohei; Takeuchi, Akio; Lee, Sujae; Unoura, Yusuke; Ami, Reiko; Murata, Takaki; Torihata, Yudai; Mikami, Tetsuhiko; Saito, Masahiro; Jin, Xun; Kanno, Takeshi; Nakagawa, Kenichiro; Ara, Nobuyuki; Asano, Naoki; Imatani, Akira; Miyazaki, Takefumi; Sato, Iwao; Sato, Toru; Ishiyama, Fumitake; Shinkai, Hirohiko; Kikuchi, H; Kusaka, Gen; Ito, Hirotaka; Iwabuchi, Tokuro; Shiroki, Takeharu; Yagi, Makoto; Yokosawa, Satoshi; Ohara, Shuichi; Toda, Shusuke; Masaka, Tomohiro; Shiga, Hisashi; Sano, Toshikazu; Fujiya, Taku

doi:10.1007/s00535-023-01967-y

Cited by 8 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the increased number of HP-eradicated individuals, an increasing number of GCs are being diagnosed in these patient groups, as GCs still emerge even after successful HP eradication [5,21,22]. Consequently, recent studies have reported that the number of diagnosed GCs among patients that are HP-eradicated has already exceeded that in those that are HP-positive [6,23], which holds true in the current study. Therefore, GC detection by EGD in eradicated individuals, compared to traditionally prevalent HP-positive GC, has great clinical implications.…”

Section: Discussionsupporting

confidence: 67%

Helicobacter pylori Eradication Does Not Adversely Affect the Clinical Course of Gastric Cancer: A Multicenter Study on Screening Endoscopic Examination in Japan

Takahashi,

Watanabe,

Fukuda

et al. 2024

Cancers

Self Cite

View full text Add to dashboard Cite

Background: Since gastric cancers (GCs) detected after Helicobacter pylori (HP) eradication present with different morphological characteristics from conventional HP-positive GCs, delayed detection of early-stage GCs may be observed. This study aimed to investigate the clinical impact of HP eradication on diagnosing GC during screening endoscopy. Methods: Eleven health checkup institutions in Japan participated in the present study. All GC cases newly diagnosed by screening endoscopy between January 2016 and December 2020 were included. After propensity score matching, multivariable regression analysis was performed to estimate the effect of HP eradication on deep tumor invasion among HP-eradicated and HP-positive GC cases. Results: A total of 231 patients with GCs (134 HP-eradicated and 97 HP-positive cases) were enrolled. After propensity score matching, there were 81 cases in each group. The distribution of the depth of tumor invasion (pT1a, pT1b1, pT1b2, and pT2) between the HP-eradicated group and HP-positive group was similar (p = 0.82). In the propensity analysis, with HP-positive as the reference value, HP eradication was not significantly associated with T1b–T4-GCs and T1b2–T4-GCs, with odds ratios (95% confidence intervals) of 1.16 (0.48–2.81) and 1.16 (0.42–3.19), respectively. Conclusions: HP eradication does not adversely affect the clinical course of GCs, supporting the recommendation of HP eradication in screening programs to reduce the total number of GC cases without delaying diagnosis.

show abstract

Section: Discussionsupporting

confidence: 67%

Helicobacter pylori Eradication Does Not Adversely Affect the Clinical Course of Gastric Cancer: A Multicenter Study on Screening Endoscopic Examination in Japan

Takahashi,

Watanabe,

Fukuda

et al. 2024

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

“…18 However, few studies have reported an association between smoking and gastric cancer post-H. pylori eradication cases. 19 In this study, smoking was also strongly associated with gastric cancer in cases that occurred after H. pylori eradication cases; however, no significant differences were observed between the status observed ≥10 and that observed <10 years after eradication. Similarly, no differences were found in the history of gastric cancer, other cancers, or family history of gastric cancer.…”

Section: Discussioncontrasting

confidence: 55%

“…A population‐based prospective cohort study reported the highest risk of gastric cancer in patients with both smoking habits and H. pylori infection 18 . However, few studies have reported an association between smoking and gastric cancer post‐ H. pylori eradication cases 19 . In this study, smoking was also strongly associated with gastric cancer in cases that occurred after H. pylori eradication cases; however, no significant differences were observed between the status observed ≥10 and that observed <10 years after eradication.…”

Section: Discussionmentioning

confidence: 99%

Multicenter study of invasive gastric cancer detected after 10 years of Helicobacter pylori eradication in Japan: Clinical, endoscopic, and histopathologic characteristics

Kobayashi,

Fujisaki,

Namikawa

et al. 2024

DEN Open

View full text Add to dashboard Cite

ObjectivesGastric cancer can be diagnosed even in patients long after Helicobacter pylori eradication. Most cases involve intramucosal lesions; however, some are invasive and require surgery. To clarify appropriate long‐term surveillance methods, this study compared invasive gastric cancer diagnosed ≥10 and <10 years after eradication.MethodsThis retrospective multicenter study included 14 institutions. We included 377 patients with gastric cancer with submucosal or deep invasion after surgical or endoscopic resection. Ordered logistic regression analysis was used to explore the factors contributing to the pathological stage and histological type.ResultsInvasive gastric cancer was detected in 84 patients (Group L) and 293 patients (Group S) ≥10 and <10 years after H. pylori eradication, respectively. Endoscopic mucosal atrophy at the time of cancer detection was similar in both groups; 50% of the patients had severe atrophy. Annual endoscopy correlated with early pathological stage (odds ratio [OR] 0.28, 95% confidence interval [CI] 0.14–0.54, p < 0.001). Group L exhibited an independent correlation with the advanced pathological stage (OR 2.27, 95% CI 1.06–4.88, p = 0.035) and the undifferentiated type (OR 2.12, 95% CI 1.16–3.90, p = 0.015). The pure differentiated type and early pathological stage significantly (p = 0.001) correlated with severe mucosal atrophy in Group S but not in Group L.ConclusionsInvasive cancers diagnosed ≥10 years after H. pylori eradication were likely to be more malignant in histological type and pathological stage. Gastric cancer surveillance should continue regardless of endoscopic atrophy, particularly ≥10 years after eradication.

show abstract

“…In addition, H. pylori infection causes oxidative stress that results in elevated levels of ROS, leading to a variety of conditions that stimulate additional ROS production or decline in antioxidant defense. ( 27 ) It is reported that smoking history was a risk factor for the prevalence of GCs, ( 28 ) and a significant trend in the GC risk with increasing smoking duration was observed. ( 29 , 30 ) There are also reports that GC development shows an independent role of smoking from H. pylori .…”

Section: Discussionmentioning

confidence: 99%

Efficacy evaluation of upper gastrointestinal endoscopy screening for secondary prevention of gastric cancer using the standardized detection ratio during a medical check-up in ‍Japan

Tanaka,

Otani,

Tamoto

et al. 2024

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

We used standardized detection ratio to evaluate the quality of nasal upper gastrointestinal endoscopy screening for the secondary prevention of gastric cancer, and examined the gastric cancer risk in the era of total Helicobacter pylori ( H. pylori ) eradication. We performed 21,931 upper gastrointestinal endoscopies, 77 subjects were diagnosed with gastric cancer. Of these, 28 had gastric cancer after H. pylori eradication, 47 had gastric cancer with H. pylori -positive or others, and 2 had H. pylori -negative gastric cancer. The Standardized detection ratios for men and women were 5.33 and 4.82, respectively. Multivariable logistic regression analyses performed exclusively on first endoscopy subjects, excluding H. pylori -negative gastric cancer, revealed that smoking was a risk factor for developing gastric cancer (adjusted odds ratio, 3.31; 95% confidence interval, 1.65–6.64; p = 0.001). A statistically significant interaction was found between daily alcohol consumpption and H. pylori eradication on gastric cancer development ( p = 0.005). In conclusion, relatively high standardized detection ratio values suggest that an appropriate endoscopic diagnosis of gastric cancer should be performed during a medical check-up. Smoking is a risk factor for developing gastric cancer, and continued alcohol consumption suggests a possible risk for developing gastric cancer after H. pylori eradication.

show abstract

Smoking history and severe atrophic gastritis assessed by pepsinogen are risk factors for the prevalence of synchronous gastric cancers in patients with gastric endoscopic submucosal dissection: a multicenter prospective cohort study

Cited by 8 publications

References 48 publications

Helicobacter pylori Eradication Does Not Adversely Affect the Clinical Course of Gastric Cancer: A Multicenter Study on Screening Endoscopic Examination in Japan

Helicobacter pylori Eradication Does Not Adversely Affect the Clinical Course of Gastric Cancer: A Multicenter Study on Screening Endoscopic Examination in Japan

Multicenter study of invasive gastric cancer detected after 10 years of Helicobacter pylori eradication in Japan: Clinical, endoscopic, and histopathologic characteristics

Efficacy evaluation of upper gastrointestinal endoscopy screening for secondary prevention of gastric cancer using the standardized detection ratio during a medical check-up in ‍Japan

Contact Info

Product

Resources

About