Smoking History Decreases Survival in Patients with Squamous Cell Carcinoma of the Mouth: A Retrospective Study with 15 Years of Follow-up

Colares, Naiara; Rodrigues, Deborah Franklin Souza; Freitas, Milena Oliveira; Dantas, Thinali Sousa; Cunha, Maria do Perpétuo Socorro Saldanha da; Sousa, Fabrício Bitú; Silva, Paulo Goberlânio de Barros

doi:10.31557/apjcp.2019.20.6.1781

Cited by 7 publications

(3 citation statements)

References 35 publications

(31 reference statements)

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“…Through retrospective analysis, this study focused on the clinicopathological factors affecting the survival time of patients with OSCC. The results found that there was no signi cant difference in survival among patients with different age, sites, and smoking (P > 0.05), which was consistent with many studies [3,4,[11][12][13][14][15].…”

Section: Discussionsupporting

confidence: 89%

A Comprehensive Survival Analysis of Oral Squamous Cell Carcinoma Patients Undergoing Initial Radical Surgery

Dong,

Xue,

Cheng

et al. 2023

Preprint

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Objective This study aims to evaluate the five-year overall survival (OS) rate and postoperative survival duration in patients diagnosed with oral squamous cell carcinoma (OSCC). Additionally, it seeks to scrutinize the clinical and pathological determinants influencing the survival outcomes in OSCC patients. Methods We meticulously gathered data from OSCC patients who underwent their first radical surgical intervention in the Department of Maxillofacial Surgery at the First Affiliated Hospital of Chongqing Medical University between April 2014 and December 2016. Follow-up was diligently conducted until March 2022. Results The study encompassed a total of 162 patients. The observed 5-year OS rate was 59.3%. Approximately 45.7% of OSCC patients experienced recurrence and metastasis post-surgery, with the 5-year overall disease-free survival rate being 49.4%. Univariate analysis revealed that clinical stage, tumor size, lymph node metastasis (pN), pathological differentiation, and recurrence and metastasis were significant factors influencing survival duration (p < 0.05). Multivariate analysis further indicated that pathological differentiation and recurrence and metastasis were independent determinants of survival duration (P < 0.05). An intriguing observation was that 11 OSCC patients were diagnosed with esophageal squamous cell carcinoma (ESCC) within 1–4 years following surgery. Conclusion The survival prognosis of OSCC patients is significantly associated with clinical stage, tumor size, lymph node metastasis (pN), pathological differentiation, and recurrence and metastasis. Pathological differentiation and recurrence and metastasis are independent determinants affecting survival duration. Routine clinical screening for esophageal squamous cell carcinoma may be recommended for OSCC patients with a history of alcohol and tobacco consumption.

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Section: Discussionsupporting

confidence: 89%

A Comprehensive Survival Analysis of Oral Squamous Cell Carcinoma Patients Undergoing Initial Radical Surgery

Dong,

Xue,

Cheng

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Through retrospective analysis, this study focused on the clinicopathological factors affecting the survival time of patients with OSCC. The results that there was no signi cant difference in survival among patients with different age , sites,and smoking (P 0.05), which was consistent with many studies [3,4,[11][12][13][14][15].…”

Section: Discussionsupporting

confidence: 89%

Survival analysis of patients with oral squamous cell carcinoma treated by radical surgery for the first time

Dong

Xue

et al. 2022

Preprint

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Objective: To investigate the five-year overall survival (OS) rate and postoperative survival time of patients with oral squamous cell carcinoma (OSCC), and to analyze the clinical and pathological factors affecting the survival of patients with OSCC.Methods: We collected the data of patients with OSCC received radical surgical treatment for the first time in the department of maxillofacial surgery of the first affiliated hospital of Chongqing medical university from Apr. 2015 to Dec 2016.Follow-up was conducted until March 2022.Results: A total of 68 patients were included in this study.Tongue (35.3%) was the most common part, followed by cheek (30.9%).The 5-year OS rate was 55.9%, about 52.9% of OSCC patients had recurrence and metastasis after surgery, and the 5-year overall disease-free survival rate was 42.6%. The univariate analysis showed that clinical stage, size of tumor, lymph node metastasis (pN), pathological differentiation and recurrence and metastasis were the exposure factors affecting survival time (p<0.05). Multivariate analysis showed that drinking, pathological differentiation and recurrence and metastasis were independent factors affecting survival time (P<0.05). Another special finding was that 4 patients with OSCC were found to suffer from esophageal squamous cell carcinoma (ESCC) within 1-4 years after surgery.Conclusion: The survival prognosis of patients with OSCC is correlated with clinical stage, size of tumor, lymph node metastasis (pN), pathological differentiation, recurrence and metastasis. drinking, pathological differentiation and recurrence and metastasis were independent factors affecting survival time. Clinical screening of esophageal squamous cell carcinoma may be performed routinely in OSCC patients with a history of alcohol and tobacco.Mini Abstract: The survival prognosis of patients with OSCC is correlated with clinical stage, size of tumor, lymph node metastasis (pN), pathological differentiation, recurrence and metastasis.

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“…Also, 41.4% of patients complained of treatment complications [ 4 ]. In another study, a 15-year follow-up examined the history of smoking in patients with SCC and concluded that smoking had little effect on the survival rate [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of recurrence, mortality and treatment complications of oral squamous cell carcinoma in public health centers in Shiraz during 2010 to 2020

et al. 2023

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Introduction Oral Squamous cell Carcinoma (OSCC) is the most common oral cancer and is treated with surgery, radiotherapy and chemotherapy. Various complications of treatment include xerostomia, mucositis, and trismus, which affect patients’ quality of life. The aim of this study is to evaluate the mortality, recurrence rate and prevalence of oral complications in treated patients. Method and materials This cross-sectional study reviewed 326 cases of patients with OSCC who were referred to public health centers in Shiraz (Khalili Hospital and Dental School) from 2010 to 2020. All patients were contacted, and the survivors were called and examined by an oral physician. A medical record was created for them, including demographic information, location of the lesion, type of treatment, history of recurrence, metastasis and oral complications. Results 53.5% of patients were male and 46.5% were female. The mean age of patients was 58.68 years. Mortality and recurrence rate was respectively 49.8% and 17.8%. The most common location of the lesion was tongue (64%). Surgery was done for all patients. 97.4% of patients complained of xerostomia, 46.2% of mucositis and 44.3% of trismus. Conclusion The most common complications of treatment are xerostomia, mucositis, and trismus, respectively. Frequent and regular follow-ups and supportive therapies reduce these complications and improve patients’ quality of life.

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Smoking History Decreases Survival in Patients with Squamous Cell Carcinoma of the Mouth: A Retrospective Study with 15 Years of Follow-up

Cited by 7 publications

References 35 publications

A Comprehensive Survival Analysis of Oral Squamous Cell Carcinoma Patients Undergoing Initial Radical Surgery

A Comprehensive Survival Analysis of Oral Squamous Cell Carcinoma Patients Undergoing Initial Radical Surgery

Survival analysis of patients with oral squamous cell carcinoma treated by radical surgery for the first time

Evaluation of recurrence, mortality and treatment complications of oral squamous cell carcinoma in public health centers in Shiraz during 2010 to 2020

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