“…A doseresponse like relationship between CS and upper respiratory conditions such as rhinitis, impaired olfaction, and sleep disturbances has also been described [26,31,32]. Further, exposure to cigarette smoke seems to be a contributory factor in chronic rhinosinusitis [9,33], with negative impact on outcome after FESS, both in adult populations (active smokers), and in pediatric populations (passive smokers) [33][34][35][36], although some studies have reported contradictory results [11,14,37]. Our study expands upon previous knowledge and adds new evidence of adverse upper respiratory effects associated with CS: in subjects seeking medical attention due to chronic upper airway complaints, CS seems to be an important determinant.…”