Smoking in spondyloarthritis: unravelling the complexities

Zhao, Sizheng Steven; Goodson, Nicola; Robertson, Selina; Gaffney, Karl

doi:10.1093/rheumatology/keaa093

Cited by 24 publications

(33 citation statements)

References 84 publications

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“…Chronic exposure to tobacco smoke through cigarette smoking is a serious public health problem that can lead to the development of serious diseases such as lung cancer, cardiovascular disease and chronic obstructive pulmonary disease (COPD) [ 24 , 25 ]. At the musculoskeletal level, there is consistent evidence that smoking is an important risk factor in the development of rheumatoid arthritis (RA), mainly in men, through its interaction with the citrullination process or with anti-citrullinated peptide antibodies (ACPAs) [ 26 , 27 ]. In the case of osteoporosis, smoking affects bone calcium homeostasis, and in osteoarthritis (OA), there is inflammation with a notable increase in oxidative stress [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

HLA-B27 may modulate the interaction between ERAP1 polymorphisms and smoking in ankylosing spondylitis patients

et al. 2022

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Background Ankylosing spondylitis (AS) is an autoimmune disease that affects the enthesis and synovial membrane of the spine, the sacroiliac vertebrae and peripheral joints. Genetic susceptibility to AS is mainly due to the presence of the HLA-B*27 (B27) allele, and endoplasmic reticulum aminopeptidase-1 (ERAP-1) plays a key role in antigen processing and presentation to HLA class I molecules. Tobacco consumption is one of the main environmental factors involved in the pathogenesis of various diseases, including AS. The objective of the present study was to evaluate the association and the interactive effects of variants of the ERAP1 gene with smoking in modulating the risk of AS. Methods and results A case–control study in the Mexican population. The association of two functional variants of the ERAP1 gene (rs30187 and rs27044) in patients with AS was analyzed by the allelic discrimination method using TaqMan probes. B27 was typified by PCR-SSP. The interaction between the variants of ERAP1 and B27 and smoking was assessed using the multifactorial dimensionality reduction (MDR) method. There was no significant association of the two variants of ERAP1 in the cases compared with the controls (P > 0.05); however, a strong interaction between the variants and smoking could be demonstrated, with entropy values of 4.97% for rs30187 and 5.13% for rs27044. In addition, these interaction effects were increased in patients carrying the B27 allele. Conclusions The rs30187 and rs27044 variants of the ERAP1 gene appear to potentiate the effect of smoking in patients with AS carrying the B27 allele.

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Section: Discussionmentioning

confidence: 99%

HLA-B27 may modulate the interaction between ERAP1 polymorphisms and smoking in ankylosing spondylitis patients

et al. 2022

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“…Costa et al [88] also reported that smoking was associated with the risk of uveitis in Portuguese patients with spondyloarthropathies. Zhao et al [89] extensively reviewed the role of tobacco habits in spondylarthritis. Moreover, Zanón-Moreno et al [90] reported in chronic glaucoma that the IL-6, caspase-3, and PARP-1 levels were significantly higher in the plasma and aqueous humor of smoking elder women than in ex-smoking and non-smoking women of the same age.…”

Section: Discussionmentioning

confidence: 99%

Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study

et al. 2021

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The purpose of this study was to identify circulating biomarkers of recurrent non-infectious anterior uveitis (NIAU), and to address the anti-inflammatory effects of triglyceride containing docosahexaenoic acid (DHA-TG). A prospective multicenter study was conducted in 72 participants distributed into: patients diagnosed with recurrent NIAU in the quiescence stage (uveitis group (UG); n = 36) and healthy controls (control group (CG); n = 36). Each group was randomly assigned to the oral supplementation of one pill/day (+) containing DHA-TG (n = 18) or no-pill condition (−) (n = 17) for three consecutive months. Data from demographics, risk factors, comorbidities, eye complications and therapy were recorded. Blood was collected and processed to determine pro-inflammatory biomarkers by bead-base multiplex assay. Statistical processing with multivariate statistical analysis was performed. The mean age was 50, 12 (10, 31) years. The distribution by gender was 45% males and 55% females. The mean number of uveitis episodes was 5 (2). Higher plasma expression of interleukin (IL)-6 was detected in the UG versus the CG (p = 5 × 10−5). Likewise, significantly higher plasma levels were seen for IL-1β, IL-2, INFγ (p = 10−4), and TNFα (p = 2 × 10−4) in the UG versus the CG. Significantly lower values of the above molecules were found in the +DHA-TG than in the -DHA-TG subgroups, after 3 months of follow-up, TNFα (p = 10−7) and IL-6 (p = 3 × 10−6) being those that most significantly changed. Signatures of circulating inflammatory mediators were obtained in the quiescent stage of recurrent NIAU patients. This 3-month follow-up strongly reinforces that a regular oral administration of DHA-TG reduces the inflammatory load and may potentially supply a prophylaxis-adjunctive mediator for patients at risk of uveitis vision loss.

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“…Nevertheless, the data so far suggests smoking may be associated with unfavourable patient reported outcomes, lower treatment adherence and response, but links with radiographic progression are inconclusive. Associations between smoking and disease severity may be underpinned by the inflammatory effects of smoking (Ambrose & Barua, 2004); CRP is ∼1.45 mg/dl higher in ever smokers versus never smokers, and 1.93 mg/dl higher in current versus non‐current smokers (Zhao et al., 2020). Furthermore, current smokers have active inflammation on MRI studies (Zhao et al., 2020).…”

Section: Methodsmentioning

confidence: 99%

“…However, smoking is actually more prevalent in patients with AS compared to the general population, compounding the already elevated risk of CVD (Papagoras et al., 2014). In 2018, ∼15% of UK adults were classified as current smokers, but the prevalence in patients with AS ranges from 24% to 29% (Zhao et al., 2020), and may be a coping mechanism for pain and boredom (Aimer et al., 2015).…”

Section: Methodsmentioning

confidence: 99%

Lifestyle modification and inflammation in people with axial spondyloarthropathy—A scoping review

Roberts

Leonard

Bishop

et al. 2022

Musculoskeletal Care

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Introduction:People with axial spondyloarthritis (AS) have an inflammatory profile, increasing the risk of hypertension, type 2 diabetes, obesity, and dyslipidaemia. Consequently, AS is linked with co-morbidities such as cardiovascular disease (CVD). Physical inactivity, diet, smoking, alcohol consumption, and obesity influence inflammation, but knowledge of the interaction between these with inflammation, disease activity, and CVD risk in AS is dominated by cross-sectional research. Methods: A review of the literature was conducted between July 2020 and December 2021. The focus of the scoping review is to summarise longitudinal and randomised control trials in humans to investigate how tracking or modifying lifestyle influences inflammation and disease burden in patients with AS. Key messages: (1) Lifestyle modifications, especially increased physical activity (PA), exercise, and smoking cessation, are critical in managing AS. (2) Smoking is negatively associated with patient reported outcome measures with AS, plus pharmaceutical treatment adherence, but links with structural radiographic progression are inconclusive. (3) Paucity of data warrant structured studies measuring inflammatory cytokine responses to lifestyle modification in AS. Conclusion: Increased PA, exercise, and smoking cessation should be supported at every given opportunity to improve health outcomes in patients with AS. The link between smoking and radiographic progression needs further investigation. Studies investigating the longitudinal effect of body weight, alcohol, and psychosocial factors on disease activity and physical function in patients with AS are needed. Given the link between inflammation and AS, future studies should also incorporate markers of chronic inflammation beyond the standard C-reactive protein and erythrocyte sedimentation rate measurements.

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Smoking in spondyloarthritis: unravelling the complexities

Cited by 24 publications

References 84 publications

HLA-B27 may modulate the interaction between ERAP1 polymorphisms and smoking in ankylosing spondylitis patients

HLA-B27 may modulate the interaction between ERAP1 polymorphisms and smoking in ankylosing spondylitis patients

Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study

Lifestyle modification and inflammation in people with axial spondyloarthropathy—A scoping review

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