Smoking increases the risk of relapse after successful tuberculosis treatment

Batista, Joana; Albuquerque, Maria de Fátima Pessoa Militão de; Ximenes, Ricardo Arraes de Alencar; Rodrigues, Laura C.

doi:10.1093/ije/dyn113

Cited by 75 publications

(29 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…11 Smoking might complicate anti-tuberculosis treatment through poor TB outcomes (e.g., relapse after treatment). 42 The association between smoking and TB may also be responsible for some of the effects observed between excess alcohol use and the outcomes in the current study.…”

Section: Discussionmentioning

confidence: 73%

Tuberculosis and excess alcohol use in the United States, 1997–2012

Volkmann¹,

Moonan²,

Miramontes³

et al. 2015

int j tuberc lung dis

View full text Add to dashboard Cite

SUMMARY BACKGROUND Excess alcohol use among tuberculosis (TB) patients complicates TB control strategies. OBJECTIVES To characterize the role of excess alcohol use in TB control, we describe the epidemiology of excess alcohol use and TB in the United States among those aged ≥15 years. DESIGN Using data reported to the National Tuberculosis Surveillance System, 1997–2012, we examined associations between excess alcohol use and TB treatment outcomes and markers for increased transmission (involvement in a local genotype cluster of cases) using multivariate logistic regression. We used Cox proportional hazards regression analysis to examine the relationship between excess alcohol use and the rate of conversion from positive to negative in sputum culture results. RESULTS Excess alcohol use was documented for 31 207 (15.1%) of 207 307 patients. Prevalence of excess alcohol use was greater among male patients (20.6%) and US-born patients (24.6%). Excess alcohol use was associated with a positive sputum smear result (aOR 1.23, 95%CI 1.18–1.28) and death during treatment (vs. completion of treatment) (aOR 1.16, 95%CI 1.10–1.22). The rate of culture conversion was higher among patients without excess alcohol use (adjusted hazard ratio 1.20, 95%CI 1.18–1.23). CONCLUSIONS Excess alcohol use was common among patients with TB, and was associated with TB transmission, lower rates of sputum culture conversion, and greater mortality.

show abstract

Section: Discussionmentioning

confidence: 73%

Tuberculosis and excess alcohol use in the United States, 1997–2012

Volkmann¹,

Moonan²,

Miramontes³

et al. 2015

int j tuberc lung dis

View full text Add to dashboard Cite

show abstract

“…A consistent study has shown that smokers are 2.5 times more likely to have a recurrence than nonsmokers 2 . Thus, the relationship between smoking, previous treatment of TB (recurrence), and resistance to anti-tuberculosis drugs deserve to be better investigated.…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with multidrug-resistant tuberculosis in Espírito Santo, Brazil

et al. 2017

View full text Add to dashboard Cite

OBJECTIVE To analyze the prevalence and factors associated with multidrug-resistant tuberculosis in Espírito Santo, Brazil.METHODS This is a cross-sectional study of cases of tuberculosis tested for first-line drugs (isoniazid, rifampicin, pyrazinamide, ethambutol, and streptomycin) in Espírito Santo between 2002 and 2012. We have used laboratory data and registration of cases of tuberculosis – from the Sistema Nacional de Agravos de Notificação and Sistema para Tratamentos Especiais de Tuberculose. Individuals have been classified as resistant and non-resistant and compared in relation to the sociodemographic, clinical, and epidemiological variables. Some variables have been included in a logistic regression model to establish the factors associated with resistance.RESULTS In the study period, 1,669 individuals underwent anti-tuberculosis drug susceptibility testing. Of these individuals, 10.6% showed resistance to any anti-tuberculosis drug. The rate of multidrug resistance observed, that is, to rifampicin and isoniazid, has been 5%. After multiple analysis, we have identified as independent factors associated with resistant tuberculosis: history of previous treatment of tuberculosis [recurrence (OR = 7.72; 95%CI 4.24–14.05) and re-entry after abandonment (OR = 3.91; 95%CI 1.81–8.43)], smoking (OR = 3.93; 95%CI 1.98–7.79), and positive culture for Mycobacterium tuberculosis at the time of notification of the case (OR = 3.22; 95%CI 1.15–8.99).CONCLUSIONS The partnership between tuberculosis control programs and health teams working in the network of Primary Health Care needs to be strengthened. This would allow the identification and monitoring of individuals with a history of previous treatment of tuberculosis and smoking. Moreover, the expansion of the offer of the culture of tuberculosis and anti-tuberculosis drug susceptibility testing would provide greater diagnostic capacity for the resistant types in Espírito Santo.

show abstract

“…For example, there is an established association between cigarette smoking and TB treatment outcomes including an increased risk of death (28) and an increased risk of relapse after successful completion of treatment (29). A recent study from Korea showed that DM and smoking independently increased the risk of death in TB patients, with the combined impact of both determinants yielding a hazard ratio for death of almost six (30).…”

Section: Discussionmentioning

confidence: 99%

Is resistance to anti-tuberculosis drugs associated with type 2 diabetes mellitus? A register review in Beijing, China

Jiang

et al. 2014

Global Health Action

View full text Add to dashboard Cite

BackgroundChina has a high burden of drug-resistant tuberculosis (TB) and diabetes mellitus (DM).ObjectiveThe objectives of this study were to determine the following in patients with culture-confirmed TB: 1) demographic characteristics and disease patterns in relation to the presence or absence of type 2 diabetes and 2) presence or absence of drug resistance to isoniazid (INH), rifampicin (RMP) or both in relation to duration of diabetes and control of diabetes.DesignThis is a cross-sectional and retrospective study involving record reviews.ResultsThere were 621 patients with culture-positive TB, of whom 187 (30%) had previously known or new type 2 diabetes. In those with diabetes, there was a significantly higher proportion of males, persons aged ≥35 years and patients registered with new TB (p<0.05). Prevalence of multidrug-resistant TB (MDR-TB) was 6.2% in new patients (N=422) and 62.3% in previously treated patients (N=199), with no significant differences between those with and without diabetes. In patients with diabetes, there was no association of drug resistance with diabetes duration or disease control [assessed by fasting blood glucose (FBG) at 1 week].ConclusionA high proportion of patients with TB in a tertiary health facility, Beijing, China, had diabetes, but there was no association between type 2 diabetes and drug-resistant TB. Further prospective studies are needed to confirm these findings.

show abstract

Smoking increases the risk of relapse after successful tuberculosis treatment

Cited by 75 publications

References 23 publications

Tuberculosis and excess alcohol use in the United States, 1997–2012

Tuberculosis and excess alcohol use in the United States, 1997–2012

Risk factors associated with multidrug-resistant tuberculosis in Espírito Santo, Brazil

Is resistance to anti-tuberculosis drugs associated with type 2 diabetes mellitus? A register review in Beijing, China

Contact Info

Product

Resources

About